What Is Ranolazine?

Ranolazine, which is also available under the names Ranozex and Ranexa, is widely used anti-anginal agent. It is commonly prescribed to patients, suffering from chest pain or non-acute angina as a part of complex therapy. The medicine may be combined with some other drugs, including beta-blockers, nitrates or agents that block calcium channels. The best effect is reached when treatment with Ranolazine is combined with other (non-medical) methods of strengthening the cardiovascular system, such as reducing cholesterol level through revising lifestyle and dieting patterns.

Nowadays, the efficiency and safety of Ranolazine is confirmed by numerous independent clinical trials. Specialists believe that the drug improves the blood flow and reduces the severity of angina attacks caused by various reasons, including stresses and physical loads.

Is it For Me?

The necessity of treatment with Ranolazine is always determined by a medical specialist, as the dug can’t be acquired over the counter. A doctor can prescribe Ranolazine or its generics to patients complaining chest pain of different nature as well as chronic angina. However, the drug is not used for relieving pain during acute angina attacks. At the same time, Ranolazine is not for you if you have serious liver disorders, because the medicine can deteriorate your state. It is also not prescribed to pregnant women.

How do I Choose the Right Dosage?

The dosage of Ranolazine is chosen by a doctor. Don’t try to change the prescribed dose: beware that increasing the dose won’t raise the efficiency of the drug, while the negative effects can become severer. The standard dosage of Ranolazine for an adult person is 500 mg of the drug twice a day. But in some cases it can be corrected.

How do I Take Ranolazine?

Take Ranozex precisely as prescribed by a specialist. If you have some questions about the time of taking the drug or dose, consult your doctor.

The medicine is available in the form of pills: these pills should be swallowed whole without crushing or chewing.

You may take Ranolazine both with and before food. Also the drug can be combined with some other medicines, but if you need to take more than one medicine at a time, consult your doctor, as some agents can interact with Ranolazine, modifying its effect.

If you missed a dose, do no not double the next one; just continue using the drug in accordance with your regular schedule.

What are the Mechanisms behind Ranolazine?

The particular mechanisms lying under the action of Ranolazine are not studied yet. As of today, it is believed that its effect is based on late sodium current inhibiting. Reducing the level of intracellular calcium causes myocardium relaxation and decresing of diastolic wentricular wall tension. The inflow of blood to the heart increases, and symptoms of angina are relieved.

What is Ranolazine Uptake Time?

Ranolazine is quickly absorbed into the bloodstream, and its peak concentration in blood is reached in the period from 2 to 7 hours after administration. If you practice a standard regimen (500 mg 2 times a day), the steady state concentration of the medicine is achieved in 3 days. Its bioavailability ranges from 35 to 50%.

How Efficient is Ranolazine?

Efficiency of Ranolazine has been officially proved by several independent placebo-controlled trials conducted with random groups of patients. In particular, it is practically assured that regular use of the recommended dose of Ranolazine mitigates symptoms of angina, relieves chest pain and increases time intervals between heart attacks. In the long-term perspective, reduced frequency and severity of heart attacks is preserved for some time even after a patient stops taking Ranolazine. There are no recorded cases of developed tolerance to the drug.

Does Ranolazine have Any Side Effects?

In general, Ranolizine is considered a safe and a well-tolerated medicine. However, like any other drug, it can cause undesired residual effects in some patients. The most common effect is dizziness – from slight to severe. Sometimes it even can result in faintness, though these cases are extremely rare. In any case, if you take Ranolazine for the first time, specialists recommend to stay at home and monitor the reaction.

Other side effects include:

  • headache, the feeling of “light head”;
  • increased heartbeat, sense of tightness in the chest;
  • feeling short of breath;
  • ringing in the ears.

If you happen to have allergic reaction to the components of Ranolazine, stop taking it immediately and call for emergency medical help.

Essential Tips on Ranolazine Use

If you started to experience some unexpected problems with urination, pain in kidneys or liver after taking Ranolazine, inform your doctor about these effects.

Keep in mind that grapefruits and grapefruit juice can make side effects from taking Ranolazine worse. Refuse from eating grapefruits if you were prescribed the drug.

Don’t change the prescribed dose without consulting a specialist. Never share your Ranolazine pills with anybody. Store and use the medicine in accordance with recommendations.

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