Coronavirus is spreading through different countries, so the humanity needs effective remedies which can treat the disease. It has been appeared that well-established antivirals may provide necessary help. A combined medication Kaletra is one of the most discussed ones, as it has been shown to have decent efficiency in fighting against coronavirus-caused illness.
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Dosage: Lopinavir 200mg / Ritonavir 50mg
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What Is Kaletra?
While medical community is tremendously working on testing already developed vaccines and developing new ones, scientists test existing methods of traditional and alternative medicine.
Lopinavir and ritonavir are well-known antivirals used for combating HIV. There is a strong scientific evidence that they may be helpful for treatment of new coronavirus (see below).
Generic Kaletra by famous Indian company Cipla Limitedcontains both ingredients in 4:1 ratio (lopinavir 200 mg and ritonavir 50 mg). It can also be dispensed under brand name Lopimune.
Is It Used in Clinical Practice for Treatment of Coronavirus?
State bodies of China recommended its use for treating the novel epidemic disease. Some Chinese patients with HIV who receive Kaletra but for some reason don’t take it,have decided to create a platform to distribute unused meds to coronavirus sufferers. Amidst loud news about Kaletra, Russian company R-Pharm announced plans to increase production of this medication to meet the increasing need for it in the pharmaceutical market. An American pharma giant AbbVie Inc. which also produces the product based on these two components donated a supply of remedies to the Chinese health authorities.
How Do Lopinavir and Ritonavir Work?
When it comes to human immunodeficiency virus therapy, lopinavir acts as a suppressor of HIV-1 and HIV-2 proteases. This prevents viral proteins from synthesis and leads to formation of immature and nonfunctioning virus. Ritonavir is also an HIV-1 and HIV-2 protease inhibitor, an active peptidomimetic that simulates the functionality of peptides. Inhibition of HIV proteases also leads to the formation of a virus that is not capable of infection. Ritonavir inhibits CYP3A isoenzyme-mediated metabolism of lopinavir in the liver, as a result of which the effectiveness of the second component of the medication increases.
But the medicine cannot kill the virus completely, this is not a cure for HIV because as this is an incurable disease. However, in case of coronavirus Kaletra administration may lead to full recovery.
Scientists believe that Kaletra affects intracellular processes of coronavirus replication thereby inhibiting its reproduction.
When to Use?
Generic Kaletra may be administered for coronavirus disease (COVID-19 caused by SARS-CoV-2) treatment solely or as a part of combination therapy,for instance, along with reverse transcriptase inhibitors. In the context of SARS epidemy (caused by SARS-CoV), there were studies confirming preventive effect of the medication against SARS-CoV. In this regard, it should be noted that SARS-CoV-2 is about 70% similar to SARS-CoV.
So, Kaletra may be potentially used as preventive agent to protect from new coronavirus.
However, clinical studies are needed to confirm whether it is true.
Is There Evidence for Effectiveness?
The WHO has been noted that the abovementioned pharmaceutical combination could provide clinical benefits. As reported byClinical Trials Arena, Lopinavir plus ritonavir in conjunction with ribavirin showed decreased fatality rate and milder illness course during clinical trials in individuals in the 2003 SARS outbreak.
How to Take Kaletra?
HIV patients should take 2 pills two times a day or 4 pills once a day. As for coronavirus, China’s National Health Commission issued a special guideline on January 27 (2020), according to which patients need to take the medication twice a day, 2 pills at a time. The regulator didn’t initially stipulated how long it should be taken, but on February 19 it updated the statement, indicating that the therapy should not last longer than 10 days.
So current guideline is as follows: 2 pills a day for up to 10 days.
What Are Contraindications?
The drug is contraindicated in the following cases:
increased sensitivity to ritonavir or lopinavir
intake of medications which are primarily metabolized via CYP3A mechanism (like Viagra, Cialis, and Amiodarone)
intake of potent CYP3A inducers which can significantly reduce lopinavir plasma concentrations (e.g. Alfuzosin, Dronedarone)
acute liver failure
consumption of St. John’s wort supplements
Caution is required when using the drug in patients with pancreatitis, hemophilia, cirrhosis, viral hepatitis B and C. The elderly should also be cautious.
Are There any Side Effects?
In some patients, adverse events may occur. They include but not limited to headache, dizziness, elevated blood sugar levels, muscle weakness, skin reactions, appetite loss, itching, nausea, and vomiting.
The medicine has a proven efficiency against coronaviruses, as it was recommended by Chinese authorities and tested in several studies. This is also a powerful HIV treatment. Kaletra from the official distributor is available for sale at My Canadian Health and Care Mall. If you need this medication, you can purchase it here safely with worldwide delivery.
Well, one of my classmates tested positive on COVID so I also got tested. The test was negative but doctors recommended me to stay home. If I develop some symptoms, I will be considered ill and should be self-quarantined. But I can ask for repeat test only if my symptoms are severe, they cannot afford to spent too many tests. Incubation period may be long, I don’t know what to expect. To feel safe, I ordered the tablets.
I’ve read that HIV combination can be helpful for fighting COVID diseases. I thought my friend with immunodeficiency could give me several pills but he said he couldn’t. Mercifully, I googled for a while and found this supplier.
There are many rumors out there now… Someone believes that vitamin C might prevent covid, others think that vitamin D deficiency boost the risk to be infected, etc. etc. But I believe that evidence-based medicine should not lie, so I’ve chosen Lopimune.
I have a friend who I had contact with about 24 hrs ago. He has cough and fever on top of that. Well, I self-isolated myself and ordered ritonavir-lopinavir combination, just to be on the safe side. You know, it's better to err on the side of caution.
This pharmacy is practical, accessible, and gives total security. Earlier I bought other medicines here, and I was pleasantly surprised when I found out that generic Kaletra is sold at My Canadian Healthcare Mall. Good job, guys!
Forewarned is forearmed! All information is important right now. I read about Lopimune by Cipla and ordered pills, just in case. I am worried because my son just suffered whooping cough. I don’t leave my house to protect myself from danger, so online shopping is good, obviously.
Australia heads into winter. Our doctors say this may negatively impact coronavirus situation. I discussed available COVID treatments with local physicians and purchased Kaletra - Lopimune. The parcel will be arriving soon.
Managed to buy while it is in stock, my personal doctor recommended to buy Kaletra. This is great, because in Hongkongese pharmacies it’s hard to find effective antivirals now. I don’t have coronavirus, thank God, but I reasonably believe that this will help me to avoid potential difficulties.