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Modern medicine does not stand still, so scientists are developing new treatments for erectile dysfunction. This is a well-established niche with powerful leaders like Viagra and Cialis, despite this, new findings will always be relevant, because current remedies are now without shortcomings. Avanafil is one of the most recent medications for ED. Is it a worthy alternative to famous ‘blue diamond’ and ‘yellow almond’?

What Is Avanafil (Stendra)?

Avanafil is an erectile dysfunction medication that is sold under the trademarks Stendra and Spedra. This medication was developed by VIVUS Inc, the final formula of Avanafil was released in 2009. The American FDA approved it in 2012, and in 2013 began the active promotion of this medicine in most European countries, as well as in New Zealand and Australia.

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The active component of the drug is characterized by a quick effect; it begins to act 15 minutes after administration and works up to 5-6 hours.

Avanafil is dosed as 50, 100, or 200 mg pills. Patients with erectile dysfunction need to swallow one tablet 20 minutes before the intended sexual intercourse at a dose of 100 mg, which is most suitable for most men.

In individual cases, you can try to take half a tablet (50 mg) or two tablets (200 mg) in the absence of the desired effect. The maximum daily dose is two hundred milligrams. Do not use the medicine more than once a day. Avanafil can be taken regardless of food intake, but grapefruit (whole fruits and juice) should be avoided during the day of Stendra intake, as well as moderate the amount of alcohol.

Want to know more about ED pills and grapefruit interactions? Read our article:

Viagra, Cialis, Levitra and Grapefruit Non-Compatibility: Mystery Revealed

Like other similar medicines, avanafil does not affect the level of hormones and does not increase libido. In order to get the desired effect, one needs to be sexually aroused. Accordingly, Avanafil does not cause an involuntary erection (except in some cases when the patient has a predisposition to priapism).

Are There Generics of Stendra?

There are some generics of Stendra, in particular, Avana, but the assortment is not so big at the moment. However, right now customers can save their money by choosing high-quality generics from reliable drugmakers.

Stendra vs Viagra: Common Features and Differences

Both Stendra and Viagra belong to the group of phosphodiesterase type 5 inhibitors, but avanafil is a second-generation inhibitor. Due to their belonging to the same class, they act in approximately the same way.

stendra vs cialis vs viagra

The main differences between these medicines:

  • different manufacturers
  • various dosages (Stendra contains a larger quantity of active ingredient)
  • common side effects of avanafil include headache and flushing, while Viagra feature higher frequency of other adverse events, such as visual disturbances and dyspepsia.

According to a study by Italian scientists P. A. Della Camera, R. Tellini (Urologia, 2019), avanafil showed a greater tolerance profile than sildenafil (Viagra) with a lower rate of adverse events and discontinuation of therapy due to such adverse events.

Despite better performance of avanafil according to scientific studies, users’ opinion may vary. For instance, according to Viagra achieved 8.6 points (out of 10, 205 reviews in total), while Stendra was ranked as low as 5.8 (51 reviews in total). Perhaps more time is needed to even out the situation, after all, Avanafil is a relatively new medication.

Avanafil is different from Cialis by a bigger amount of criteria, in particular, Cialis can be used for BPH (unlike Avana) and works up to 38 hrs.


It seems impossible to issue an unconditional verdict regarding superiority of Stendra or, vice versa, Viagra. One or another medication can work better depending on a particular patient. You may try Viagra and then switch to Stendra (if needed), or use the opposite scenario.

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The information on our site is provided strictly for informational purposes and should not be regarded as medical advice. Self-medication is also not recommended, especially when it comes to prescription drugs. If you have initial symptoms of some illness, it is advisable to contact your doctor (before starting the treatment) and / or visit a clinic for qualified help. If you’ve already taken avanafil with no side effects, it would be a good solution for you.

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I’m an Oncologist and Hematology Specialist primary located in Bryn Mawr, Pennsylvania. I have over 55 years of experience in the medical field and more than 20 years of practice. I’m skilled at the treatment & diagnosis of a large array of ailments & diseases in adults.

Board certifications

  • American Board of Internal Medicine Certification in Internal Medicine
  • American Board of Hematology Certification in Hematology
  • American Board of Medical Oncology Certification in Medical Oncology