Active Ingredient

Acamprosate

Acamprosate is a medication used to support the treatment of alcohol dependence. It is typically prescribed to help individuals who have stopped drinking alcohol to maintain their abstinence.

It works best when used in combination with counseling and social support. Acamprosate is not a cure for alcohol dependence but can be an effective part of a comprehensive treatment plan.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Available Acamprosate Brands

Acamprol

Strengths 333 mg

Acamprosate Uses

Acamprosate is primarily used to help maintain abstinence in individuals recovering from alcohol dependence. It is part of a broader treatment plan that includes psychological support.

Supporting abstinence in alcohol dependence
Reducing the craving for alcohol
Helping maintain sobriety after detoxification

How Acamprosate Works

Acamprosate works by restoring the balance of certain neurotransmitters in the brain that are disrupted by chronic alcohol use. It helps stabilize the chemical signals in the brain, reducing the physical distress and emotional discomfort that can lead to relapse.

By modulating the activity of glutamate and GABA neurotransmitters, Acamprosate helps decrease cravings and supports abstinence from alcohol.

Common side effects of Acamprosate

Not everyone experiences side effects with Acamprosate, and many side effects are mild and temporary. However, it’s important to be aware of them.

Diarrhea
Nausea
Abdominal pain
Fatigue
Headache
Insomnia
Dizziness

If you experience serious or persistent symptoms, contact your healthcare provider.

Take Acamprosate as directed by your healthcare provider, and do not adjust your dose without consulting them.
Avoid consuming alcohol while taking this medication.
Inform your doctor about any other medications you are taking to avoid potential interactions.
Monitor for any unusual changes in mood or behavior and report them to your healthcare provider.
Avoid driving or operating machinery if you experience dizziness or drowsiness.

Always consult your doctor if you have any concerns or questions about your treatment with Acamprosate.

Frequently Asked Questions

How long does it take for Acamprosate to work?

The effects of Acamprosate may take several days to become noticeable. It is important to continue taking it as prescribed even if you do not feel immediate effects.

Can I drink alcohol while taking Acamprosate?

It is advised to avoid alcohol while taking Acamprosate, as the medication is intended to support abstinence and reduce cravings.

Does Acamprosate cause weight gain?

Weight gain is not a common side effect of Acamprosate. If you have concerns about weight changes, discuss them with your healthcare provider.

Is Acamprosate safe to use long-term?

Acamprosate is generally considered safe for long-term use when taken as prescribed. Regular follow-up with your healthcare provider is recommended.

Can Acamprosate be taken with other medications?

Acamprosate can interact with other medications. Always inform your healthcare provider about all medications you are taking to ensure safe use.