Chlorthalidone

Chlorthalidone is a medication that belongs to the class of drugs known as diuretics, commonly referred to as ‘water pills’. It is primarily used to help reduce excess fluid in the body and manage high blood pressure.

By promoting the removal of excess salt and water, it helps to lower blood pressure and reduce swelling caused by fluid retention.

Information about Chlorthalidone

Chlorthalidone Uses

Chlorthalidone is commonly used in the management of several conditions related to fluid retention and blood pressure.

High blood pressure (hypertension)
Heart failure
Edema associated with kidney disorders
Edema due to liver disease

How Chlorthalidone Works

Chlorthalidone works by increasing the amount of urine your body makes, which helps to remove excess salt and water.

This action helps to reduce the volume of fluid in the blood vessels, which in turn lowers blood pressure and reduces swelling.

As a thiazide-like diuretic, it primarily acts on the kidneys to promote this effect.

Common side effects of Chlorthalidone

Not everyone will experience side effects from taking Chlorthalidone, and many side effects are mild and temporary.

Dizziness
Increased urination
Thirst
Stomach upset
Muscle weakness
Fatigue
Headache

If side effects are severe or persistent, it is important to contact a healthcare professional.

CONTENT DETAILS

Written By

Douglas C. Goldberg, MD

Reviewed By

Philip Schein, MD

Last updated

28 Nov 2025 | 03:00 PM (UTC)

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Expert advice for Chlorthalidone

Monitor your blood pressure regularly to ensure the medication is working effectively.
Avoid consuming large amounts of alcohol as it can increase certain side effects.
Discuss any other medications or supplements you are taking with your doctor to prevent interactions.
Do not start or stop taking this medication without consulting your healthcare provider.
If you experience symptoms like severe dizziness or muscle cramps, seek medical advice promptly.

Always consult your doctor or healthcare provider for personalized medical advice.

Frequently Asked Questions

What does Chlorthalidone do?

Chlorthalidone helps to reduce high blood pressure and decrease fluid retention by promoting the removal of excess salt and water from the body.

How long does it take for Chlorthalidone to work?

The effects on blood pressure may be noticeable within a few days, but it may take several weeks to see the full benefits.

Can I drink alcohol while taking Chlorthalidone?

It’s best to limit alcohol consumption while taking Chlorthalidone as it can enhance certain side effects like dizziness.

What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue your regular schedule.

Are there any foods I should avoid while taking Chlorthalidone?

There are no specific foods to avoid, but maintaining a balanced diet and limiting salt intake can help manage blood pressure effectively.