Active Ingredient

Cilostazol

Cilostazol is a medication used to improve blood flow in patients with certain circulatory conditions. It helps to relieve symptoms by widening blood vessels and reducing blood clotting.

This medication is often prescribed for people experiencing pain in the legs due to poor circulation, commonly known as intermittent claudication.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Available Cilostazol Brands

Pletal

Strengths 50mg, 100mg

Cilostazol Uses

Cilostazol is primarily used to manage symptoms related to poor circulation in the legs.

Intermittent claudication
Improving walking distance in patients with peripheral artery disease
Reducing leg pain caused by narrowed arteries

How Cilostazol Works

Cilostazol works by inhibiting an enzyme called phosphodiesterase III, which plays a role in blood clotting and vessel constriction.

By blocking this enzyme, Cilostazol helps to widen blood vessels and improve blood flow.

This action helps to reduce symptoms like pain and cramping in the legs during exercise.

Common side effects of Cilostazol

Not everyone experiences side effects with Cilostazol, and many are mild and temporary.

Headache
Dizziness
Diarrhea
Palpitations
Nausea
Abdominal pain
Swelling of the ankles or feet

If you experience serious or persistent side effects, contact your doctor.

Monitor your symptoms and report any unusual changes to your doctor.
Avoid heavy alcohol consumption while taking this medication.
Inform your doctor of any other medications you are taking to avoid interactions.
Do not use Cilostazol if you have certain heart conditions; consult your doctor for advice.
Be cautious when standing up quickly, as Cilostazol may cause dizziness.

Always consult your healthcare provider for personalized advice.

Frequently Asked Questions

What is Cilostazol used for?

Cilostazol is used to improve symptoms of poor circulation in the legs, such as pain and cramping during exercise.

How long does it take for Cilostazol to work?

Some patients may notice improvement in symptoms within a few weeks, but it can take up to 12 weeks for full benefits.

Can I take Cilostazol with food?

Cilostazol is usually taken on an empty stomach, but follow your doctor’s instructions regarding food.

Are there any foods or drinks I should avoid while taking Cilostazol?

It’s advisable to limit alcohol intake and discuss any dietary concerns with your doctor.

Is Cilostazol safe for everyone?

Cilostazol may not be suitable for people with certain heart conditions. Always consult your doctor before starting the medication.