Active Ingredient

Clomipramine

Clomipramine is a medication that belongs to the class of tricyclic antidepressants. It is primarily used to manage certain mental health conditions.

This medication can help improve mood, relieve anxiety, and increase energy levels in individuals with specific disorders.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Available Clomipramine Brands

Anafranil

Strengths 10 mg, 25mg, 50mg, 75mg

Clofranil

Strengths 25 mg

Clomipramine Uses

Clomipramine is commonly prescribed for a variety of mental health conditions. It helps manage symptoms and improve quality of life.

Obsessive-compulsive disorder (OCD)
Depression
Panic disorder
Chronic pain syndromes
Cataplexy associated with narcolepsy

How Clomipramine Works

Clomipramine works by affecting the balance of certain chemicals in the brain known as neurotransmitters. It primarily increases the levels of serotonin and norepinephrine.

By improving the balance of these chemicals, Clomipramine can help alleviate symptoms of depression and anxiety.

This mechanism can also reduce the occurrence of obsessive and compulsive behaviors in individuals with OCD.

Common side effects of Clomipramine

Not everyone experiences side effects with Clomipramine, and many are mild and temporary. However, some common side effects can occur.

Dry mouth
Dizziness
Constipation
Nausea
Increased sweating
Blurred vision
Weight gain
Fatigue

If you experience serious or persistent side effects, it’s important to contact your doctor.

Monitor your symptoms and report any worsening to your healthcare provider.
Avoid consuming alcohol while taking this medication, as it may increase drowsiness.
Inform your doctor about any other medications or supplements you are taking to avoid interactions.
Do not stop taking Clomipramine suddenly without consulting your doctor.
Be cautious when driving or operating machinery until you know how Clomipramine affects you.

Always consult your doctor for personalized advice and guidance when taking Clomipramine.

Frequently Asked Questions

What is Clomipramine used for?

Clomipramine is used to treat obsessive-compulsive disorder, depression, panic disorder, and certain other conditions.

How long does it take for Clomipramine to work?

It may take several weeks to feel the full benefits of Clomipramine. It’s important to continue taking it as prescribed.

Can I drink alcohol while taking Clomipramine?

It is advisable to avoid alcohol while taking Clomipramine, as it can increase side effects like drowsiness.

Are there any foods I should avoid while taking Clomipramine?

There are no specific foods to avoid, but maintaining a balanced diet is recommended. Consult your doctor for personalized advice.

Can Clomipramine be taken during pregnancy?

You should discuss the potential risks and benefits with your doctor if you are pregnant or planning to become pregnant while taking Clomipramine.