Active Ingredient

Domperidone

Domperidone is a medication that helps alleviate nausea and vomiting. It is often used in situations where these symptoms are caused by various conditions, such as digestive issues.

It works by affecting specific receptors in the body to help improve digestion and reduce discomfort.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Available Domperidone Brands

Motilium

Strengths 10mg

Domperidone Uses

Domperidone is primarily used to manage symptoms related to digestive health.

Relief of nausea and vomiting
Management of bloating and discomfort
Alleviating symptoms of gastroparesis
Helping with the feeling of fullness after meals

How Domperidone Works

Domperidone works by blocking dopamine receptors in the gut. This action helps to increase the movement of the stomach and intestines, aiding in the faster passage of food.

By enhancing digestive tract motility, it helps reduce symptoms such as nausea and bloating.

As a dopamine antagonist, it specifically targets receptors that influence gastrointestinal activity.

Common side effects of Domperidone

Not everyone experiences side effects from Domperidone, and many are mild and temporary.

Dry mouth
Headache
Dizziness
Stomach cramps
Diarrhea
Skin rash
Fatigue

If you experience serious or persistent side effects, contact your healthcare provider.

Frequently Asked Questions

What does Domperidone do?

Domperidone helps reduce nausea and vomiting by improving the movement of the digestive tract.

How quickly does Domperidone work?

The effects of Domperidone can usually be felt within a short time after taking it, but this can vary between individuals.

Is Domperidone safe for long-term use?

The safety of long-term use should be evaluated by a healthcare provider, as it may depend on individual health conditions.

Can Domperidone be taken with other medications?

Domperidone may interact with other medications. It’s important to discuss all medications you are taking with your healthcare provider.

What should I avoid while taking Domperidone?

Avoid alcohol and inform your doctor about any other medications you are taking to prevent potential interactions.