Estradiol

Estradiol is a form of estrogen, a female sex hormone that plays a crucial role in many bodily functions. It is commonly used in hormone replacement therapy and other medical treatments.

Estradiol is often prescribed to address symptoms related to menopause and other hormonal imbalances.

Information about Estradiol

Estradiol Uses

Estradiol is used to manage and treat various conditions related to hormonal imbalances.

Treatment of menopausal symptoms like hot flashes and night sweats.
Prevention of osteoporosis in postmenopausal women.
Management of hypoestrogenism due to hypogonadism, castration, or primary ovarian failure.
Treatment of certain types of breast cancer in both women and men.
Management of advanced prostate cancer in men.

How Estradiol Works

Estradiol works by supplementing the body with estrogen, which is crucial for various functions in the body. It helps in maintaining the health of the reproductive system.

By binding to estrogen receptors, estradiol helps regulate the growth and development of female sexual characteristics and reproductive functions.

It also plays a role in bone density maintenance, cholesterol management, and skin health.

Common side effects of Estradiol

Not everyone experiences side effects from estradiol, and many are mild and temporary. However, it is important to be aware of potential side effects.

Nausea
Headache
Breast tenderness
Weight changes
Mood changes
Irregular vaginal bleeding or spotting
Swelling in hands or feet

If you experience serious or persistent symptoms, contact your healthcare provider.

CONTENT DETAILS

Written By

Douglas C. Goldberg, MD

Reviewed By

Philip Schein, MD

Last updated

28 Nov 2025 | 03:00 PM (UTC)

Medicine brands for Estradiol

Estrace
Dosage: 1mg, 2mg
from $42.0013 variant(s)

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Expert advice for Estradiol

Monitor your symptoms and report any unusual changes to your doctor.
Avoid smoking as it may increase the risk of serious side effects.
Limit alcohol consumption while taking estradiol.
Inform your doctor about any other medications or supplements you are taking to avoid interactions.
Do not use estradiol if you have a history of certain medical conditions such as blood clots or certain cancers without consulting your doctor.

Always consult your healthcare provider for personalized medical advice.

Frequently Asked Questions

What is estradiol used for?

Estradiol is used to treat symptoms of menopause, prevent osteoporosis, and manage certain cancers and hormonal imbalances.

How long does it take for estradiol to work?

The effects of estradiol can vary, but some symptoms may improve within a few weeks. Consult your doctor for more details.

Can estradiol cause weight gain?

Weight changes are a possible side effect of estradiol. If you notice significant changes, discuss them with your doctor.

Is estradiol safe for long-term use?

Long-term use of estradiol should be monitored by a healthcare provider, as it may increase certain health risks.

Can I take estradiol with other medications?

You should inform your doctor about all medications you’re taking as estradiol can interact with other drugs.