Active Ingredient

Glibenclamide

Glibenclamide is a medication used to help control blood sugar levels in individuals with type 2 diabetes. It works by stimulating the pancreas to release insulin, which lowers blood sugar.

This medication is usually part of a comprehensive treatment plan that may include diet, exercise, and other diabetes medications.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Glibenclamide Uses

Glibenclamide is primarily used to manage blood sugar levels in adults with type 2 diabetes.

Helps control high blood sugar
Part of a diabetes management plan
Used when diet and exercise alone are not enough

How Glibenclamide Works

Glibenclamide belongs to a class of drugs known as sulfonylureas. It helps lower blood sugar by causing the pancreas to produce more insulin.

Insulin is a hormone that helps the body use sugar efficiently. By increasing insulin production, Glibenclamide helps keep blood sugar levels in check.

Common side effects of Glibenclamide

Not everyone experiences side effects from Glibenclamide, and many side effects are mild and temporary.

Nausea
Heartburn
Feeling full
Weight gain
Low blood sugar (hypoglycemia)
Skin rash

If you experience serious or persistent side effects, contact your doctor.

Frequently Asked Questions

How quickly does Glibenclamide work?

Glibenclamide starts working within a few hours, but full effects may take some time. Consult your doctor for more information.

Can I take Glibenclamide if I am pregnant?

You should discuss with your doctor if you are pregnant or planning to become pregnant while taking Glibenclamide.

What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember. If it’s close to your next dose, skip the missed dose. Do not double the dose.

Can I drink alcohol while taking Glibenclamide?

It’s best to limit alcohol intake while taking Glibenclamide, as it can affect blood sugar levels. Discuss with your doctor for specific advice.

What are the signs of low blood sugar?

Signs of low blood sugar include sweating, dizziness, shaking, and feeling hungry. If you experience these, consume a quick source of sugar and contact your doctor.