Active Ingredient

Indomethacin

Indomethacin is a medication used to relieve pain and reduce inflammation. It is often prescribed for conditions that involve swelling and discomfort.

This medication is typically used in situations where inflammation needs to be controlled, such as in arthritis or certain types of headaches.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Available Indomethacin Brands

Indocin

Strengths 25mg, 50mg, 75mg

Indomethacin Uses

Indomethacin is commonly used to manage various conditions associated with pain and inflammation.

Rheumatoid arthritis
Osteoarthritis
Ankylosing spondylitis
Acute gouty arthritis
Bursitis and tendonitis

How Indomethacin Works

Indomethacin works by blocking the production of certain natural substances in the body that cause inflammation. It inhibits enzymes known as cyclooxygenases (COX), which are involved in the inflammatory process.

By reducing the activity of these enzymes, indomethacin helps decrease swelling, pain, and fever.

Common side effects of Indomethacin

Not everyone experiences side effects from indomethacin, and many side effects are mild and temporary.

Headache
Nausea
Dizziness
Stomach upset
Heartburn
Diarrhea
Drowsiness

If you experience serious or persistent symptoms, contact your doctor.

Frequently Asked Questions

What does indomethacin do?

Indomethacin helps reduce pain and inflammation by blocking certain substances in the body.

How long does it take for indomethacin to work?

The effects of indomethacin can be felt within a few hours, but it may take longer for full relief.

Is indomethacin safe for long-term use?

Long-term use of indomethacin should be monitored by a doctor due to potential side effects.

Can I take indomethacin with other pain relievers?

You should consult your doctor before combining indomethacin with other pain medications to avoid interactions.

Are there any foods or drinks I should avoid while taking indomethacin?

It’s advisable to avoid alcohol and discuss any dietary restrictions with your doctor while taking indomethacin.