Active Ingredient

Isosorbide Dinitrate

Isosorbide Dinitrate is a medication primarily used to prevent chest pain (angina) in patients with certain heart conditions. It helps improve blood flow to the heart, reducing the heart’s workload.

This medication is not suitable for immediate relief of chest pain but is used as part of a regular treatment plan to manage symptoms.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Available Isosorbide Dinitrate Brands

Isordil

Strengths 5mg, 10mg

Sorbitrate

Strengths 5 mg, 10 mg

Isosorbide Dinitrate Uses

Isosorbide Dinitrate is commonly used for the following conditions:

Prevention of angina pectoris (chest pain)
Management of heart failure
Improvement of exercise tolerance in patients with heart conditions
Relief of symptoms in certain types of heart disease

How Isosorbide Dinitrate Works

Isosorbide Dinitrate works by relaxing and widening blood vessels, which helps to increase the supply of blood and oxygen to the heart. This action reduces the heart’s workload and helps to prevent angina attacks.

By lowering blood pressure and reducing strain on the heart, it can also help manage chronic heart failure.

Common side effects of Isosorbide Dinitrate

Not everyone experiences side effects with Isosorbide Dinitrate, and many are mild and temporary. Common side effects include:

Headache
Dizziness
Lightheadedness
Nausea
Flushing
Fatigue
Low blood pressure

If you experience serious or persistent side effects, contact your doctor for advice.

Monitor your symptoms and inform your doctor of any changes.
Avoid consuming large amounts of alcohol while taking this medication.
Do not use Isosorbide Dinitrate if you have severe anemia or certain other heart conditions without a doctor’s advice.
Inform your healthcare provider about all other medications you are taking to avoid interactions.
Be cautious when standing up quickly from a sitting or lying position to prevent dizziness.

Always consult your doctor for personalized medical advice.

Frequently Asked Questions

What is Isosorbide Dinitrate used for?

It is used to prevent chest pain (angina) and manage certain heart conditions.

How quickly does Isosorbide Dinitrate work?

Isosorbide Dinitrate is used for prevention and not for immediate relief. It is part of a regular treatment plan.

Can I drink alcohol while taking Isosorbide Dinitrate?

It’s advisable to limit alcohol consumption as it can increase the risk of side effects like dizziness.

Are there any common side effects of Isosorbide Dinitrate?

Yes, common side effects include headache, dizziness, and nausea, among others.

Can Isosorbide Dinitrate be taken with other medications?

You should inform your doctor about all medications you are taking to avoid potential interactions.