Active Ingredient

Isotretinoin

Isotretinoin is a medication primarily used to treat severe acne that has not responded to other treatments. It helps in reducing the formation of acne and promoting skin renewal.

It is typically prescribed for cases where other acne treatments have failed to show significant improvement.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Available Isotretinoin Brands

Isotroin

Strengths 10 mg, 20 mg, 30mg

Isofair

Strengths 10mg, 20mg

Tretiva

Strengths 5mg, 10mg, 20mg, 30mg, 40mg

Sotret

Strengths 20 mg, 30 mg

Accufine

Strengths 30mg

Accutane

Strengths 5mg, 10mg, 20mg, 30mg, 40mg

Isotretinoin Uses

Isotretinoin is mainly used for skin-related issues, particularly severe forms of acne. Here are some common uses:

Treatment of severe nodular acne.
Management of cystic acne.
Reduction of acne scars.
Improvement of skin texture in severe cases.

How Isotretinoin Works

Isotretinoin works by reducing the amount of oil released by oil glands in your skin. This helps your skin renew itself more quickly.

It belongs to a class of drugs known as retinoids, which are derivatives of vitamin A.

The medication decreases facial oil production and helps in reducing inflammation and bacteria on the skin.

Common side effects of Isotretinoin

Not everyone experiences side effects with Isotretinoin, and many side effects are mild and temporary. Here are some common ones:

Dry skin and lips.
Chapped lips.
Dry eyes.
Nosebleeds.
Itching or rash.
Increased sensitivity to sunlight.

If you experience serious or persistent side effects, contact your doctor.

Avoid excessive exposure to sunlight and use sunscreen when outdoors.
Do not use waxing or laser treatments while on Isotretinoin and for some time after stopping.
Avoid taking vitamin A supplements while using this medication.
Inform your doctor about any other medications you are taking to avoid interactions.
Refrain from consuming large amounts of alcohol.

Always consult your doctor if you have any concerns or experience unusual symptoms.

Frequently Asked Questions

How long does it take for Isotretinoin to work?

Isotretinoin may take several weeks to show noticeable improvement in acne. It’s important to complete the full course as prescribed by your doctor.

Can Isotretinoin be used for mild acne?

Isotretinoin is generally prescribed for severe acne that hasn’t responded to other treatments. It is not typically used for mild acne.

Is it safe to consume alcohol while taking Isotretinoin?

It’s advisable to limit alcohol consumption while on Isotretinoin, as both can affect liver function.

Does Isotretinoin cause permanent changes to the skin?

Isotretinoin can lead to long-term improvement in acne, but it may also cause some temporary side effects on the skin, such as dryness.

Can I use other acne treatments while on Isotretinoin?

You should consult your doctor before using other acne treatments with Isotretinoin to avoid potential interactions or increased irritation.