Active Ingredient

Leflunomide

Leflunomide is a medication commonly used to manage certain autoimmune conditions. It helps control symptoms and improve quality of life for those affected by chronic inflammatory diseases.

This drug is often prescribed when other treatments have not been effective or are not suitable.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Available Leflunomide Brands

Arava

Strengths 10mg, 20mg

Leflunomide Uses

Leflunomide is primarily used to treat autoimmune conditions by reducing inflammation and slowing disease progression.

Rheumatoid arthritis
Psoriatic arthritis
Other autoimmune disorders as advised by a healthcare professional

How Leflunomide Works

Leflunomide works by inhibiting an enzyme involved in the proliferation of immune cells. This reduces inflammation and slows the progression of autoimmune diseases.

By targeting specific pathways in the immune system, it helps to manage symptoms and prevent joint damage.

Common side effects of Leflunomide

Not everyone experiences side effects with Leflunomide, and many are mild and temporary. However, some common side effects include:

Diarrhea
Nausea
Rash
Hair loss
Dizziness
Stomach pain
Headache

If you experience serious or persistent symptoms, contact your healthcare provider.

Regularly monitor your liver function as advised by your doctor.
Avoid consuming large amounts of alcohol while taking this medication.
Inform your doctor about any other medications you are taking to prevent interactions.
Do not use Leflunomide if you are pregnant or planning to become pregnant.
Report any signs of infection or unusual symptoms to your healthcare provider promptly.

Always consult your doctor for personalized advice and before making any changes to your medication regimen.

Frequently Asked Questions

What is Leflunomide used for?

Leflunomide is used to treat autoimmune conditions like rheumatoid arthritis and psoriatic arthritis by reducing inflammation.

How long does it take for Leflunomide to work?

It may take several weeks to notice improvement in symptoms. It’s important to continue taking it as prescribed by your doctor.

Can I drink alcohol while taking Leflunomide?

It’s advisable to limit alcohol consumption as both alcohol and Leflunomide can affect liver function.

Are there any foods to avoid while taking Leflunomide?

There are no specific foods to avoid, but maintaining a balanced diet can help manage your condition effectively.

Is Leflunomide safe during pregnancy?

Leflunomide is not recommended during pregnancy due to potential risks to the developing fetus. Discuss alternatives with your doctor.