Active Ingredient

Melatonin

Melatonin is a hormone naturally produced by the pineal gland in the brain. It plays a crucial role in regulating sleep-wake cycles.

As a supplement, melatonin is often used to help with sleep-related issues. It can be beneficial for those experiencing difficulty falling asleep or maintaining a regular sleep pattern.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Available Melatonin Brands

Melatonin

Strengths 3mg

Meloset

Strengths 3 mg

Melatonin Uses

Melatonin is commonly used to address sleep disturbances and other related conditions.

Insomnia
Jet lag
Shift work sleep disorder
Delayed sleep phase disorder
Sleep problems in children with developmental disorders

How Melatonin Works

Melatonin works by signaling to the body that it is time to sleep, helping to regulate the sleep-wake cycle.

It mimics the natural hormone produced in the brain, promoting a feeling of sleepiness.

By adjusting the body’s internal clock, melatonin can help improve sleep onset and quality.

Common side effects of Melatonin

Not everyone experiences side effects from melatonin, and many are mild and temporary.

Drowsiness
Headache
Dizziness
Nausea
Stomach discomfort
Vivid dreams
Daytime sleepiness

If you experience serious or persistent side effects, contact a healthcare professional.

Avoid driving or operating heavy machinery after taking melatonin, as it may cause drowsiness.
Limit alcohol consumption, which can interfere with melatonin’s effectiveness.
Discuss with a doctor if you have a history of depression or autoimmune disorders before using melatonin.
Monitor your body’s response, especially if you are using other medications.
Do not use melatonin if you are pregnant or breastfeeding without consulting a healthcare provider.

Always consult with a healthcare professional before starting any new supplement or treatment.

Frequently Asked Questions

What does melatonin do?

Melatonin helps regulate the sleep-wake cycle by signaling to your body that it is time to sleep.

How long does it take for melatonin to work?

The effects of melatonin can vary, but many people start to feel sleepy within an hour of taking it.

Is melatonin safe to use every night?

Melatonin is generally considered safe for short-term use. Consult a healthcare provider for advice on long-term use.

Can I take melatonin with other medications?

Melatonin can interact with certain medications. It’s important to discuss with a healthcare professional before combining it with other treatments.

Does melatonin have any dietary restrictions?

There are no specific dietary restrictions, but it’s advisable to avoid alcohol as it can reduce the effectiveness of melatonin.