Active Ingredient

Mesalamine

Mesalamine is a medication primarily used to treat inflammatory bowel diseases. It helps manage symptoms by reducing inflammation in the intestines.

It is often prescribed for conditions like ulcerative colitis, helping to control flare-ups and maintain remission.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Available Mesalamine Brands

Asacol

Strengths 400mg

Mesalamine Uses

Mesalamine is commonly used for managing inflammatory conditions of the bowel. It helps reduce symptoms and maintain remission in affected individuals.

Treatment of mild to moderate ulcerative colitis
Maintenance of remission in ulcerative colitis
Management of Crohn’s disease in some cases
Reducing inflammation in the colon

How Mesalamine Works

Mesalamine works by decreasing inflammation in the colon, which helps alleviate symptoms of bowel diseases.

It acts locally in the gut to inhibit the production of certain chemicals that trigger inflammation.

This helps to reduce swelling, pain, and tissue damage in the intestines.

Common side effects of Mesalamine

Not everyone will experience side effects from Mesalamine, and many side effects are mild and temporary.

Headache
Nausea
Abdominal pain
Diarrhea
Flatulence
Dizziness
Fatigue

If you experience any serious or persistent symptoms, contact your healthcare provider.

Monitor your symptoms and report any significant changes to your doctor.
Avoid consuming large amounts of alcohol while taking Mesalamine.
Inform your doctor about any other medications or supplements you are taking to avoid interactions.
If you experience severe abdominal pain or rectal bleeding, seek medical attention immediately.
Do not stop taking Mesalamine suddenly without consulting your doctor.

Always consult your healthcare provider for advice tailored to your health condition.

Frequently Asked Questions

How long does it take for Mesalamine to work?

Mesalamine may take a few weeks to show noticeable improvements in symptoms. It’s important to continue taking it as prescribed.

Can I drink alcohol while taking Mesalamine?

It’s advisable to limit alcohol consumption as it may increase the risk of side effects. Consult your doctor for personalized advice.

What should I do if I miss a dose of Mesalamine?

If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double up.

Are there any dietary restrictions while taking Mesalamine?

There are no specific dietary restrictions, but maintaining a balanced diet can support your overall health. Discuss any concerns with your doctor.

Can Mesalamine be used during pregnancy?

If you are pregnant or planning to become pregnant, discuss with your doctor whether Mesalamine is appropriate for you.