Active Ingredient

Metaxalone

Metaxalone is a medication used to relieve discomfort associated with acute, painful musculoskeletal conditions. It is typically prescribed as part of a complete treatment plan that includes rest and physical therapy.

This medication helps to ease muscle pain and improve mobility, making it easier to perform daily activities.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Available Metaxalone Brands

Skelaxin

Strengths 400mg

Metaxalone Uses

Metaxalone is commonly used to manage muscle pain and stiffness. It is often recommended for:

Relief of muscle spasms
Alleviating muscle pain due to strains or sprains
Improving mobility in musculoskeletal conditions

How Metaxalone Works

Metaxalone works by acting on the central nervous system to relax muscles. It does not directly relax tense muscles but helps reduce the sensation of pain and discomfort.

As a skeletal muscle relaxant, it helps ease muscle stiffness and improve movement.

Although the exact mechanism is not fully understood, it is believed to interrupt pain signals in the brain.

Common side effects of Metaxalone

Not everyone experiences side effects from Metaxalone, and many side effects are mild and temporary. Common side effects may include:

Drowsiness
Dizziness
Nausea
Headache
Stomach upset
Fatigue
Dry mouth

If you experience serious or persistent symptoms, it is important to contact your doctor.

Avoid consuming alcohol while taking Metaxalone, as it may increase drowsiness.
Be cautious when driving or operating machinery, as this medication can cause dizziness or drowsiness.
Inform your doctor about any other medications you are taking to avoid potential interactions.
Do not use Metaxalone if you have severe liver or kidney problems without consulting a healthcare provider.
Report any unusual symptoms or allergic reactions to your doctor immediately.

Always consult your doctor for personalized medical advice and before starting or stopping any medication.

Frequently Asked Questions

What is Metaxalone used for?

Metaxalone is used to relieve discomfort from muscle spasms and pain associated with acute musculoskeletal conditions.

How quickly does Metaxalone work?

Metaxalone typically begins to work within a few hours, but the exact time can vary based on individual response.

How long do the effects of Metaxalone last?

The effects of Metaxalone can last for several hours, but this can vary depending on individual factors and the condition being treated.

Is Metaxalone safe for long-term use?

Metaxalone is generally used for short-term relief of muscle pain. Long-term use should be discussed with a healthcare provider.

Can I take Metaxalone with other medications?

You should inform your doctor about all medications you are taking, as Metaxalone can interact with other drugs, potentially altering its effects.