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Naltrexone
Naltrexone is a medication used to help manage dependence on alcohol or opioids. It is not a cure but can support recovery efforts by reducing cravings and the pleasurable effects of these substances.
It is typically part of a comprehensive treatment plan that includes counseling and support from healthcare professionals.
Information about Naltrexone
Naltrexone Uses
Naltrexone is used in various treatment settings to assist individuals in overcoming substance dependence.
- Management of alcohol dependence
- Support in opioid dependence treatment
- Prevention of relapse in opioid use disorder
How Naltrexone Works
Naltrexone works by blocking the effects of opioids in the brain. It attaches to opioid receptors but does not activate them, preventing the ‘high’ associated with opioid use.
This helps reduce cravings and can be an effective part of a recovery program for opioid and alcohol dependence.
Common side effects of Naltrexone
Not everyone experiences side effects with naltrexone, and many are mild and temporary.
- Nausea
- Headache
- Dizziness
- Tiredness
- Trouble sleeping
- Anxiety
- Joint or muscle pain
If you experience serious or persistent side effects, contact your doctor.
CONTENT DETAILS
Written By
Douglas C. Goldberg, MD
Reviewed By
Philip Schein, MD
Last updated
28 Nov 2025 | 03:00 PM (UTC)
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Expert advice for Naltrexone
- Avoid consuming large amounts of alcohol while taking naltrexone.
- Inform your doctor about any other medications you are taking to avoid interactions.
- Do not use naltrexone if you have acute hepatitis or liver failure.
- Monitor for any unusual symptoms and report them to your doctor.
- Do not stop taking naltrexone abruptly without consulting your healthcare provider.
Always follow your doctor’s advice and attend regular follow-up appointments.
Frequently Asked Questions
How does naltrexone help with alcohol dependence?
Naltrexone reduces the craving for alcohol and the pleasure associated with drinking, supporting abstinence.
How long does it take for naltrexone to start working?
Naltrexone may start to work within a few days, but its full effects can take several weeks.
Can I take naltrexone with other medications?
Naltrexone may interact with other medications. Always inform your doctor about all the medications you are taking.
Is naltrexone safe for long-term use?
Naltrexone is generally considered safe for long-term use when monitored by a healthcare provider.
What should I do if I miss a dose of naltrexone?
If you miss a dose, take it as soon as you remember, unless it’s almost time for your next dose. Do not double the dose to catch up.