Active Ingredient

Nateglinide

Nateglinide is an oral medication used to help manage blood sugar levels in adults with type 2 diabetes. It is typically part of a complete treatment plan that includes diet and exercise.

This medication works by stimulating the pancreas to release insulin, which helps lower blood sugar levels after meals.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Available Nateglinide Brands

Starlix

Strengths 120mg

Nateglinide Uses

Nateglinide is primarily used to manage blood sugar levels in individuals with type 2 diabetes. It is often used alongside other diabetes medications.

Control blood sugar levels in type 2 diabetes
Used in combination with other diabetes medications
Helps prevent complications related to high blood sugar

How Nateglinide Works

Nateglinide belongs to the meglitinide class of drugs. It works by stimulating the pancreas to produce more insulin.

This action helps to lower blood sugar levels, especially after meals, by increasing the amount of insulin in the bloodstream.

By acting on the beta cells of the pancreas, it helps to manage blood sugar spikes effectively.

Common side effects of Nateglinide

Not everyone experiences side effects with Nateglinide, and many side effects are mild and temporary. However, some common side effects include:

Headache
Nausea
Dizziness
Diarrhea
Back pain
Cold-like symptoms
Joint pain

If you experience serious or persistent symptoms, contact your healthcare provider.

Monitor your blood sugar levels regularly as advised by your doctor.
Avoid consuming alcohol excessively, as it can affect blood sugar levels.
Be aware of symptoms of low blood sugar, such as dizziness or sweating, and know how to manage them.
Inform your doctor about all medications you are taking to avoid potential interactions.
Do not use Nateglinide if you have severe liver or kidney problems without consulting your doctor.

Always consult your healthcare provider for personalized advice and before making any changes to your treatment plan.

Frequently Asked Questions

How quickly does Nateglinide work?

Nateglinide begins to work soon after you take it, helping to control blood sugar spikes after meals.

Can Nateglinide be used with other diabetes medications?

Yes, Nateglinide is often used in combination with other diabetes medications to better manage blood sugar levels.

Is it safe to drink alcohol while taking Nateglinide?

It’s best to limit alcohol consumption, as it can affect your blood sugar levels. Discuss your alcohol intake with your doctor.

What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember, unless it’s almost time for your next dose. Do not double up on doses.

Can Nateglinide cause low blood sugar?

Yes, like many diabetes medications, Nateglinide can cause low blood sugar. It’s important to be aware of the symptoms and how to manage them.