Active Ingredient

Pentoxifylline

Pentoxifylline is a medication used to improve blood flow in certain conditions. It helps by making the blood less sticky, which can enhance circulation.

This medication is often prescribed for individuals with circulation problems, particularly those affecting the arms and legs.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Available Pentoxifylline Brands

Trental

Strengths 400mg

Pentoxifylline Uses

Pentoxifylline is primarily used to manage conditions related to poor blood circulation. It can help alleviate symptoms and improve quality of life.

Intermittent claudication (pain in the legs due to poor circulation)
Peripheral artery disease
Chronic occlusive arterial disease
Vascular dementia
Raynaud’s phenomenon

How Pentoxifylline Works

Pentoxifylline works by decreasing the thickness of the blood, which helps it flow more easily through the blood vessels. This can improve circulation and reduce symptoms associated with poor blood flow.

As a vasodilator, it helps to widen blood vessels, allowing for better blood flow.

This action can be particularly beneficial in conditions where blood supply is restricted.

Common side effects of Pentoxifylline

Not everyone will experience side effects with Pentoxifylline, and many are mild and temporary. However, some common side effects may occur.

Nausea
Dizziness
Headache
Stomach upset
Flushing
Heartburn
Diarrhea

If you experience serious or persistent symptoms, contact your doctor for advice.

Monitor your symptoms and report any significant changes to your doctor.
Avoid heavy alcohol consumption while taking this medication.
Inform your doctor about any other medications you are taking to avoid interactions.
Do not use Pentoxifylline if you have certain medical conditions without consulting your doctor.
Be cautious if you experience dizziness, especially when standing up quickly.

Always follow your healthcare provider’s advice and check with them if you have any concerns.

Frequently Asked Questions

What does Pentoxifylline do?

Pentoxifylline helps improve blood flow by making the blood less sticky, which can enhance circulation in the body.

How long does it take for Pentoxifylline to work?

The effects of Pentoxifylline may take several weeks to become noticeable. It’s important to take it consistently as prescribed.

Can I take Pentoxifylline with other medications?

You should inform your doctor about all medications you are taking, as Pentoxifylline can interact with other drugs.

Is Pentoxifylline safe for everyone?

Pentoxifylline may not be suitable for individuals with certain medical conditions. Always consult your doctor before starting it.

Can I drink alcohol while taking Pentoxifylline?

It’s advisable to avoid heavy alcohol consumption while taking Pentoxifylline, as it can increase the risk of side effects.