Active Ingredient

Permethrin

Permethrin is an antiparasitic medication commonly used to treat infestations caused by certain parasites. It is often applied topically to the skin.

This medication is generally used in situations where a person is affected by lice or scabies, providing relief by eliminating the parasites.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Available Permethrin Brands

Acticin

Strengths 30g

Elimite

Strengths 30 gm

Permethrin Uses

Permethrin is primarily used to treat and prevent infestations caused by parasites on the skin.

Treatment of head lice infestations.
Treatment of scabies, a condition caused by tiny mites that infest the skin.
Prevention of lice in individuals who have been exposed to someone with an infestation.

How Permethrin Works

Permethrin works by affecting the nervous system of parasites, leading to their paralysis and death. This action effectively eliminates the infestation.

As an antiparasitic agent, it targets the parasites without significant absorption into the human body, making it a localized treatment option.

By disrupting the normal function of the parasites’ nerve cells, permethrin ensures that they cannot survive or reproduce.

Common side effects of Permethrin

Not everyone experiences side effects when using permethrin. Most side effects are mild and temporary.

Itching at the site of application.
Redness or rash on the skin.
Tingling sensation or numbness.
Scalp irritation, if used for head lice.
Burning or stinging sensation.

If you experience severe or persistent symptoms, contact your healthcare provider.

Frequently Asked Questions

How quickly does permethrin work?

Permethrin starts working soon after application, with most parasites being killed within hours.

Is permethrin safe for everyone?

Permethrin is generally safe for most adults, but it’s important to consult a doctor, especially if you have allergies or skin conditions.

Can I use permethrin if I'm pregnant or breastfeeding?

Consult your healthcare provider before using permethrin if you are pregnant or breastfeeding to ensure it’s safe for you.

Can permethrin be used on children?

Permethrin is often used for children with lice or scabies, but it’s important to follow a doctor’s guidance for proper use.

Are there any interactions with other medications?

Permethrin is primarily a topical treatment and has minimal systemic absorption, but always inform your doctor of all medications you are taking.