Active Ingredient

Pirfenidone

Pirfenidone is a medication primarily used to manage certain lung conditions. It helps slow down the progression of fibrosis, a type of tissue scarring, in the lungs.

This medication is often prescribed for adults with specific chronic lung diseases. It is important to use it under medical supervision.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Available Pirfenidone Brands

Esbriet

Strengths 200 mg

Pirfenex

Strengths 200 mg, 400 mg, 600 mg, 801 mg

Pirfenidone Uses

Pirfenidone is used for managing and treating certain lung conditions characterized by fibrosis.

Idiopathic pulmonary fibrosis (IPF)
Other chronic fibrotic lung conditions as determined by a healthcare provider

How Pirfenidone Works

Pirfenidone works by reducing the production of certain chemicals in the body that lead to inflammation and fibrosis.

It helps to slow down the scarring process in the lungs, which can improve breathing and lung function over time.

As an antifibrotic agent, it is thought to modulate the activity of several pathways involved in fibrosis.

Common side effects of Pirfenidone

Not everyone will experience side effects from Pirfenidone, and many side effects are mild and temporary.

Nausea
Fatigue
Diarrhea
Rash
Loss of appetite
Headache
Dizziness
Heartburn

If you experience serious or persistent side effects, contact your doctor.

Avoid heavy alcohol consumption while taking this medication.
Monitor for any unusual symptoms and report them to your healthcare provider.
Do not use if you experience severe allergic reactions.
Be cautious when driving or operating machinery if you feel dizzy.
Avoid exposure to strong sunlight and use sunscreen, as Pirfenidone may increase sensitivity to sunlight.

Always consult your doctor for any concerns or questions regarding your treatment.

Frequently Asked Questions

What is Pirfenidone used for?

Pirfenidone is used to treat idiopathic pulmonary fibrosis and other similar lung conditions as advised by a doctor.

How does Pirfenidone work?

It works by reducing inflammation and slowing down the scarring process in the lungs.

Can I drink alcohol while taking Pirfenidone?

It is advisable to avoid heavy alcohol consumption while on Pirfenidone. Discuss any alcohol use with your doctor.

What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. Do not double up doses.

Are there any foods or drinks to avoid while taking Pirfenidone?

Avoid grapefruit and grapefruit juice, as they may interact with Pirfenidone. Always consult your doctor for specific dietary advice.