Active Ingredient

Podophyllotoxin

Podophyllotoxin is a medication commonly used to treat certain skin conditions. It is derived from the roots of the Podophyllum plant.

This compound is particularly effective in managing external genital warts.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Available Podophyllotoxin Brands

Podofilox

Strengths 20-10-ml

Podophyllotoxin Uses

Podophyllotoxin is primarily used for treating skin conditions caused by viral infections.

Treatment of external genital warts
Management of plantar warts
Occasionally used for other types of warts under medical supervision

How Podophyllotoxin Works

Podophyllotoxin works by stopping the growth of wart cells. It interferes with the cell division process, leading to the destruction of the wart tissue.

As an antimitotic agent, it targets rapidly dividing cells, which are characteristic of warts.

Common side effects of Podophyllotoxin

Not everyone experiences side effects with podophyllotoxin, and many are mild and temporary.

Redness at the application site
Itching or irritation
Burning sensation
Swelling
Dry skin
Ulceration at the application site

If you experience serious or persistent symptoms, contact your doctor.

Frequently Asked Questions

How long does it take for podophyllotoxin to work?

The effects of podophyllotoxin can vary, but improvement is often seen within a few weeks of starting treatment.

Can podophyllotoxin be used on all types of warts?

Podophyllotoxin is primarily used for external genital warts and should not be used for other types of warts without medical advice.

Is podophyllotoxin safe during pregnancy?

Podophyllotoxin is not recommended during pregnancy. Consult your doctor for safer alternatives.

Can I use podophyllotoxin with other medications?

It’s important to discuss all medications you are taking with your doctor to avoid potential interactions.

What should I do if I miss a dose?

If you miss a dose, apply it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and continue with your regular schedule.