Active Ingredient

Probenecidum

Probenecidum is a medication used to help manage certain conditions related to uric acid levels in the body. It is primarily used in adults who need to lower their uric acid levels.

This medication can be an important part of treatment plans for individuals with specific health conditions, but it should be used under medical supervision.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Available Probenecidum Brands

Benemid

Strengths 500mg

Probenecidum Uses

Probenecidum is typically used to manage conditions associated with high uric acid levels.

Gout management
Prevention of gout attacks
Enhancing the effectiveness of certain antibiotics
Managing hyperuricemia in chemotherapy patients

How Probenecidum Works

Probenecidum works by increasing the excretion of uric acid in the urine. This helps to lower uric acid levels in the blood.

It acts on the kidneys to reduce the reabsorption of uric acid, promoting its elimination from the body.

This mechanism helps prevent the formation of uric acid crystals, which can cause pain and inflammation.

Common side effects of Probenecidum

Not everyone experiences side effects from Probenecidum, and many are mild and temporary. However, some common side effects include:

Headache
Nausea
Dizziness
Loss of appetite
Stomach upset
Rash
Flushing

If you experience serious or persistent symptoms, contact your doctor.

Monitor your symptoms and report any unusual changes to your doctor.
Avoid consuming large amounts of alcohol while taking this medication.
Inform your healthcare provider about all other medications you are taking to avoid interactions.
Do not take this medication if you have a history of kidney stones without consulting your doctor.
Stay hydrated to help reduce the risk of kidney stones.

Always consult your doctor before making any changes to your medication regimen.

Frequently Asked Questions

What is Probenecidum used for?

Probenecidum is used to manage conditions associated with high uric acid levels, such as gout and hyperuricemia.

How does Probenecidum work?

It works by increasing the excretion of uric acid through the urine, thus lowering its levels in the blood.

Can Probenecidum interact with other medications?

Yes, Probenecidum can interact with other medications. It’s important to inform your doctor about all the medicines you are taking.

Are there any dietary restrictions while taking Probenecidum?

While on Probenecidum, it’s advisable to avoid excessive alcohol intake and stay hydrated. Discuss dietary concerns with your doctor.

What should I do if I miss a dose of Probenecidum?

If you miss a dose, take it as soon as you remember. If it’s near the time of your next dose, skip the missed dose. Do not double up.