Active Ingredient

Prochlorperazine

Prochlorperazine is a medication used to manage nausea, vomiting, and certain mental health conditions. It belongs to a class of drugs known as antipsychotics.

It is often prescribed when other medications have not been effective in controlling symptoms. Prochlorperazine can be used for both short-term and ongoing treatment plans.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Available Prochlorperazine Brands

Compazine

Strengths 5mg

Prochlorperazine Uses

Prochlorperazine is commonly used to treat a variety of conditions related to nausea and mental health.

Control of severe nausea and vomiting
Treatment of schizophrenia
Management of anxiety
Relief of severe migraine symptoms

How Prochlorperazine Works

Prochlorperazine works by blocking dopamine receptors in the brain. This action helps to balance neurotransmitters, which can reduce symptoms of nausea, vomiting, and certain mental health disorders.

By affecting these receptors, it can also help in managing anxiety and other mood-related conditions.

Common side effects of Prochlorperazine

Not everyone experiences side effects with Prochlorperazine, and many are mild and temporary. However, some common side effects include:

Drowsiness
Dizziness
Dry mouth
Blurred vision
Constipation
Restlessness
Weight gain

If you experience any severe or persistent side effects, it is important to contact your healthcare provider.

Avoid consuming alcohol while taking Prochlorperazine as it can increase drowsiness.
Inform your doctor about any other medications you are taking to avoid potential interactions.
Do not drive or operate heavy machinery if you feel drowsy or dizzy.
Contact your healthcare provider if you experience symptoms such as severe muscle stiffness or an irregular heartbeat.
Regular monitoring by your doctor is recommended to assess your response to the medication.

Always consult your doctor for personalized medical advice.

Frequently Asked Questions

What does Prochlorperazine treat?

Prochlorperazine is used to treat nausea, vomiting, schizophrenia, anxiety, and migraines.

How long does it take for Prochlorperazine to work?

The onset of relief can vary, but some patients may notice improvement within a few hours.

Is Prochlorperazine safe for long-term use?

Prochlorperazine can be used long-term under medical supervision. Regular check-ups are advised to monitor its effects.

Can Prochlorperazine be taken with other medications?

It’s important to inform your doctor about all medications you are taking to avoid interactions.

What should I do if I miss a dose of Prochlorperazine?

If you miss a dose, take it as soon as you remember unless it’s close to the time for your next dose. Do not double up doses.