Active Ingredient

Progesterone

Progesterone is a naturally occurring hormone in the body that plays a crucial role in the menstrual cycle and pregnancy. It is also used as a medication to treat various conditions related to hormone imbalance.

Progesterone may be prescribed to support pregnancy, help regulate menstrual cycles, or as part of hormone replacement therapy.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Available Progesterone Brands

Progesterone

Strengths 200 mg

Prometrium

Strengths 100mcg, 200mcg

Progesterone Uses

Progesterone is used in several medical conditions related to hormone balance.

Regulating menstrual cycles
Supporting early pregnancy
Treating abnormal uterine bleeding
As part of hormone replacement therapy in menopause
Managing symptoms of premenstrual syndrome (PMS)

How Progesterone Works

Progesterone works by preparing the lining of the uterus to receive and support a fertilized egg. It is essential for maintaining pregnancy in the early stages.

In hormone replacement therapy, it helps balance estrogen levels and reduces the risk of endometrial hyperplasia.

Progesterone also influences other body systems, contributing to overall hormonal balance.

Common side effects of Progesterone

Not everyone experiences side effects from progesterone, and many are mild and temporary.

Headache
Nausea
Dizziness
Breast tenderness
Mood swings
Tiredness
Stomach upset

If you experience serious or persistent symptoms, contact your doctor.

Frequently Asked Questions

What does progesterone do in the body?

Progesterone helps regulate the menstrual cycle and supports early stages of pregnancy by preparing the uterus lining.

How long does it take for progesterone to work?

The effects of progesterone can vary depending on the condition being treated. Consult your doctor for specific guidance.

Is progesterone safe to use long-term?

Progesterone is generally considered safe when used under medical supervision, but long-term use should be regularly reviewed by your doctor.

Can progesterone interact with other medications?

Yes, progesterone can interact with other medications. Always inform your doctor about all the medicines you are taking.

What should I do if I miss a dose of progesterone?

If you miss a dose, take it as soon as you remember unless it’s almost time for your next dose. Do not double up doses.