Active Ingredient

Raloxifene

Raloxifene is a medication that belongs to the class of Selective Estrogen Receptor Modulators (SERMs). It is primarily used to help maintain bone health in specific conditions.

This medication is often prescribed to women who are at risk of osteoporosis or have already been diagnosed with it. It may also be used in other situations as determined by a healthcare provider.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Available Raloxifene Brands

Evista

Strengths 60mg

Raloxifene Uses

Raloxifene is commonly used to address bone health and other conditions related to estrogen.

Prevention and treatment of osteoporosis in postmenopausal women
Reduction in the risk of invasive breast cancer in postmenopausal women with osteoporosis
Reduction in the risk of invasive breast cancer in postmenopausal women at high risk for breast cancer

How Raloxifene Works

Raloxifene works by mimicking the effects of estrogen on certain parts of the body, such as bones. This helps to maintain bone density and reduce the risk of fractures.

While it acts like estrogen in some tissues, it blocks the effects of estrogen in others, such as breast tissue, which can help reduce the risk of breast cancer.

As a SERM, it selectively binds to estrogen receptors, producing beneficial effects on bone and lipid metabolism without stimulating breast or uterine tissues.

Common side effects of Raloxifene

Not everyone experiences side effects with Raloxifene, and many of them are mild and temporary. However, some common side effects may occur.

Hot flashes
Leg cramps
Swelling of the hands, feet, or ankles
Flu-like symptoms
Joint pain
Increased sweating

If you experience any serious or persistent symptoms, it’s important to contact your doctor.

Monitor for any unusual symptoms and report them to your healthcare provider.
Avoid prolonged periods of immobility, as this can increase the risk of blood clots.
Limit alcohol consumption while taking this medication.
Inform your doctor of any other medications or supplements you are taking to avoid potential interactions.
Do not use if you have a history of blood clots or are at high risk for them.

Always consult your doctor before starting or stopping any medication.

Frequently Asked Questions

What is Raloxifene used for?

Raloxifene is used to prevent and treat osteoporosis in postmenopausal women and to reduce the risk of invasive breast cancer in certain women.

How does Raloxifene work?

It works by acting like estrogen on bones, helping to maintain bone density, while blocking estrogen’s effects on breast tissue.

Can men use Raloxifene?

Raloxifene is primarily prescribed for postmenopausal women. Its use in men is not common and should be discussed with a doctor.

Are there any dietary restrictions while taking Raloxifene?

There are no specific dietary restrictions, but it’s important to maintain a balanced diet rich in calcium and vitamin D.

What should I do if I miss a dose of Raloxifene?

If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue with your regular schedule.