Active Ingredient

Repaglinide

Repaglinide is a medication used to help control blood sugar levels in adults with type 2 diabetes. It is often prescribed when diet and exercise alone are not enough to manage blood sugar effectively.

This medication works by stimulating the pancreas to release insulin, which helps lower blood sugar levels after meals. It is usually part of a comprehensive treatment plan that includes lifestyle changes.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Available Repaglinide Brands

Prandin

Strengths 0.5 mg, 1mg, 2mg

Repaglinide Uses

Repaglinide is commonly used to manage type 2 diabetes in adults. It helps control blood sugar levels as part of a broader diabetes management plan.

Managing blood sugar levels in type 2 diabetes
Used in combination with diet and exercise
Helps prevent complications related to high blood sugar

How Repaglinide Works

Repaglinide belongs to a class of drugs known as meglitinides. It works by stimulating the pancreas to release more insulin.

Insulin is a hormone that helps lower blood sugar levels by allowing sugar to enter cells where it can be used for energy.

By increasing insulin release, repaglinide helps manage blood sugar levels, especially after meals.

Common side effects of Repaglinide

Not everyone experiences side effects with repaglinide, and many side effects are mild and temporary. However, some people may notice certain common side effects.

Low blood sugar (hypoglycemia)
Headache
Stomach upset
Diarrhea
Joint pain

If you experience serious or persistent symptoms, contact your doctor for advice.

Monitor your blood sugar levels regularly as advised by your healthcare provider.
Avoid skipping meals to reduce the risk of low blood sugar.
Limit alcohol consumption, as it can affect blood sugar levels.
Inform your doctor of any other medications or supplements you are taking to avoid interactions.
Do not use repaglinide if you have type 1 diabetes or diabetic ketoacidosis.

Always consult your doctor or healthcare provider for personalized advice and recommendations.

Frequently Asked Questions

How quickly does repaglinide work?

Repaglinide works quickly to lower blood sugar levels, usually within an hour of taking it.

Can I take repaglinide with other diabetes medications?

Repaglinide can be used with other diabetes medications, but always under the guidance of your healthcare provider.

What should I do if I miss a dose?

If you miss a dose of repaglinide, take it as soon as you remember unless it’s almost time for your next dose. Do not double up on doses.

Is it safe to drive while taking repaglinide?

Be cautious when driving or operating machinery, as repaglinide can cause low blood sugar, which may affect your ability to concentrate.

Can repaglinide cause weight gain?

Some people may experience weight gain while taking repaglinide. It’s important to follow a balanced diet and exercise plan to help manage your weight.