Active Ingredient

Roflumilast

Roflumilast is a medication used to help manage certain lung conditions. It is primarily prescribed for adults with chronic obstructive pulmonary disease (COPD).

This medication works by reducing inflammation in the lungs, which can help improve breathing and prevent flare-ups.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Available Roflumilast Brands

Daliresp

Strengths 500 mg

Roflumilast Uses

Roflumilast is typically used in the management of specific lung conditions to improve breathing and reduce symptoms.

Chronic obstructive pulmonary disease (COPD)
Prevention of COPD exacerbations
Chronic bronchitis management

How Roflumilast Works

Roflumilast works by inhibiting an enzyme called phosphodiesterase-4 (PDE4) found in the lungs. This action helps to decrease inflammation.

By reducing inflammation, Roflumilast can help the airways in the lungs stay open, making it easier to breathe.

This mechanism can help reduce the frequency and severity of COPD flare-ups.

Common side effects of Roflumilast

Not everyone experiences side effects with Roflumilast, and many are mild and temporary. However, some common side effects include:

Diarrhea
Nausea
Headache
Decreased appetite
Weight loss
Insomnia
Abdominal pain

If you experience serious or persistent symptoms, contact your doctor for advice.

Monitor your symptoms and report any significant changes to your healthcare provider.
Avoid heavy alcohol consumption while taking this medication.
Inform your doctor about any other medications you are taking to avoid potential interactions.
Do not use Roflumilast if you experience severe weight loss without consulting your doctor.
Keep regular appointments with your healthcare provider to monitor your condition.

Always consult your doctor for personal medical advice and before making any changes to your medication regimen.

Frequently Asked Questions

How does Roflumilast help with COPD?

Roflumilast helps by reducing inflammation in the lungs, which can improve breathing and reduce the frequency of flare-ups.

How long does it take for Roflumilast to work?

The effects of Roflumilast may take several weeks to become noticeable. It’s important to continue taking it as prescribed.

Can Roflumilast be taken with other medications?

Roflumilast can interact with other medications. It’s important to inform your doctor about all medications you are taking.

What should I do if I miss a dose of Roflumilast?

If you miss a dose, take it as soon as you remember unless it’s almost time for your next dose. Do not double up doses.

Are there any lifestyle changes I should make while taking Roflumilast?

Consider maintaining a healthy diet and avoiding smoking to support your lung health while taking Roflumilast.