Active Ingredient

Saxagliptin

Saxagliptin is a medication used to manage blood sugar levels in adults with type 2 diabetes. It is often prescribed as part of a complete treatment plan that includes diet and exercise.

This medication helps to control high blood sugar, which can prevent kidney damage, blindness, nerve problems, and loss of limbs. Managing diabetes also reduces the risk of a heart attack or stroke.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Available Saxagliptin Brands

Onglyza

Strengths 5mg

Saxagliptin Uses

Saxagliptin is primarily used to help control blood sugar levels in adults with type 2 diabetes. It is not used for type 1 diabetes or diabetic ketoacidosis.

Management of type 2 diabetes
Improvement of blood sugar control in combination with diet and exercise
Possible use in combination with other diabetes medications

How Saxagliptin Works

Saxagliptin works by inhibiting an enzyme called dipeptidyl peptidase-4 (DPP-4). This enzyme breaks down incretin hormones, which are involved in the regulation of blood sugar levels.

By inhibiting DPP-4, saxagliptin increases the levels of incretin hormones, helping to stimulate insulin release and reduce the amount of sugar produced by the liver.

Common side effects of Saxagliptin

While not everyone experiences side effects, some people may encounter mild and temporary effects when using saxagliptin.

Headache
Upper respiratory tract infection
Urinary tract infection
Stomach upset
Joint pain
Sore throat

If you experience serious or persistent symptoms, contact your doctor for advice.

Monitor your blood sugar levels regularly to ensure they remain within the target range.
Avoid consuming large amounts of alcohol while taking this medication.
Inform your doctor of any other medications you are taking to avoid potential interactions.
Do not use saxagliptin if you have a history of pancreatitis.
Seek medical attention if you experience severe abdominal pain or symptoms of an allergic reaction.

Always consult your doctor or healthcare provider for personalized medical advice.

Frequently Asked Questions

How does saxagliptin affect blood sugar levels?

Saxagliptin helps to lower blood sugar levels by increasing insulin production and decreasing sugar production in the liver.

When will I start to notice the effects of saxagliptin?

The effects of saxagliptin on blood sugar levels may be noticed within a few weeks, but it can vary among individuals.

Can saxagliptin be taken with other diabetes medications?

Yes, saxagliptin can be used in combination with other diabetes medications, but this should be done under the guidance of a healthcare provider.

Are there any foods or drinks I should avoid while taking saxagliptin?

It is advisable to limit alcohol intake and maintain a balanced diet while taking saxagliptin. Discuss specific dietary concerns with your doctor.

Is saxagliptin safe for everyone with type 2 diabetes?

Saxagliptin may not be suitable for everyone. Individuals with certain medical conditions or those taking specific medications should consult their doctor.