Active Ingredient

Sevelamer

Sevelamer is a medication used to control high phosphate levels in the blood, particularly in patients with chronic kidney disease on dialysis. It helps prevent complications associated with high phosphate levels.

This medication is often part of a comprehensive treatment plan that includes dietary restrictions and other medications.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Available Sevelamer Brands

Renagel

Strengths 400 mg, 800mg

Sevelamer Uses

Sevelamer is primarily used to manage phosphate levels in specific medical conditions.

Chronic kidney disease on dialysis
Hyperphosphatemia
Prevention of bone disease due to high phosphate levels

How Sevelamer Works

Sevelamer works by binding to phosphate in the digestive tract. This reduces the amount of phosphate that gets absorbed into the bloodstream.

By lowering phosphate levels, it helps to maintain a balance of minerals in the body, which is crucial for bone health and preventing complications.

Common side effects of Sevelamer

Not everyone experiences side effects from Sevelamer, and many are mild and temporary. Common side effects include:

Nausea
Vomiting
Stomach pain
Diarrhea
Constipation
Indigestion
Gas

If you experience serious or persistent symptoms, contact your doctor.

Take Sevelamer with meals to improve its effectiveness.
Avoid taking other medications close to when you take Sevelamer to prevent interactions.
Inform your doctor about any other medical conditions, especially digestive issues.
Limit foods high in phosphorus as advised by your healthcare provider.
Avoid excessive alcohol consumption while using this medication.

Always consult your doctor for personalized advice and before starting or stopping any medication.

Frequently Asked Questions

What is Sevelamer used for?

Sevelamer is used to control high phosphate levels in patients with chronic kidney disease on dialysis.

How does Sevelamer work?

It binds to phosphate in the digestive tract, reducing its absorption into the bloodstream.

Can I take Sevelamer with other medications?

It’s best to take other medications at a different time to avoid interactions. Consult your doctor for guidance.

What should I do if I miss a dose?

If you miss a dose, take it with your next meal. Do not double up on doses.

Are there any dietary restrictions while taking Sevelamer?

You may need to limit foods high in phosphorus. Your healthcare provider can give specific dietary advice.