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Tacrolimus
Tacrolimus is an immunosuppressant medication commonly used to help prevent organ rejection after a transplant. It works by modulating the immune system to reduce its activity.
This medication is crucial in maintaining the health of transplanted organs and is typically part of a broader treatment plan.
Information about Tacrolimus
Tacrolimus Uses
Tacrolimus is used primarily in organ transplantation to prevent the body from rejecting the new organ. It is also utilized in other conditions as directed by a healthcare provider.
- Preventing organ rejection in kidney transplants
- Preventing organ rejection in liver transplants
- Preventing organ rejection in heart transplants
- Treating certain skin conditions like eczema when other treatments have not worked
How Tacrolimus Works
Tacrolimus works by suppressing the immune system, which is responsible for attacking foreign tissues, such as transplanted organs. By reducing immune activity, it helps prevent the body from rejecting the new organ.
It achieves this by inhibiting a protein called calcineurin, which is crucial for activating T-cells, a type of white blood cell involved in the immune response.
Common side effects of Tacrolimus
Not everyone experiences side effects with Tacrolimus, and many side effects are mild and temporary. However, it is important to be aware of potential reactions.
- Headache
- Nausea
- Diarrhea
- Insomnia
- Tremors
- Increased blood pressure
- Kidney function changes
If you experience serious or persistent symptoms, contact your doctor for advice.
CONTENT DETAILS
Written By
Douglas C. Goldberg, MD
Reviewed By
Philip Schein, MD
Last updated
28 Nov 2025 | 03:00 PM (UTC)
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Expert advice for Tacrolimus
- Regularly monitor your blood pressure and kidney function as advised by your healthcare provider.
- Avoid consuming grapefruit or grapefruit juice, as it can interfere with Tacrolimus levels in the body.
- Be cautious with alcohol consumption, as it may increase the risk of side effects.
- Inform your doctor about any other medications or supplements you are taking to avoid potential interactions.
- Do not discontinue use without consulting your healthcare provider, even if you feel well.
Always consult your doctor for personalized medical advice and before making any changes to your treatment plan.
Frequently Asked Questions
What does Tacrolimus do?
Tacrolimus helps prevent the body from rejecting transplanted organs by suppressing the immune system.
How long does it take for Tacrolimus to work?
Tacrolimus begins to work shortly after administration, but its full effects may take some time to be noticeable.
Can Tacrolimus cause weight gain?
Weight gain is not a common side effect of Tacrolimus, but changes in weight can occur. Consult your doctor if you have concerns.
Is it safe to consume alcohol while taking Tacrolimus?
Alcohol may increase the risk of side effects with Tacrolimus. It is best to discuss alcohol use with your healthcare provider.
Can I take Tacrolimus with other medications?
Tacrolimus can interact with other medications. Always inform your doctor about all the medications you are taking.