Active Ingredient

Trazodone

Trazodone is a medication primarily used to treat mood disorders. It is commonly prescribed to help manage depression and anxiety.

It can also be used in other conditions as determined by a healthcare provider.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Available Trazodone Brands

Strengths 100mg

Desyrel

Strengths 25 mg, 50 mg, 100mg

Trazodone is typically used to address various mental health conditions. It may be prescribed for:

Trazodone works by affecting the balance of neurotransmitters in the brain, particularly serotonin.

It helps to improve mood, relieve anxiety, and promote better sleep by enhancing serotonin activity.

This action helps alleviate symptoms associated with depression and anxiety.

Not everyone experiences side effects with Trazodone, and many are mild and temporary. Common side effects include:

If side effects are severe or persistent, contacting a doctor is advised.

Avoid consuming alcohol as it can increase drowsiness.
Be cautious when driving or operating machinery until you know how Trazodone affects you.
Inform your doctor of any other medications you are taking to avoid interactions.
Do not stop taking Trazodone suddenly without consulting your healthcare provider.
If you experience any unusual changes in mood or behavior, contact your doctor immediately.

Always consult your doctor for personalized advice and recommendations.

What is Trazodone used for?

Trazodone is used to treat depression and anxiety disorders. It may also help with insomnia related to depression.

How long does it take for Trazodone to work?

Some people may notice improvements in sleep within a few days, but mood changes can take a few weeks.

Can Trazodone cause weight gain?

Weight changes can occur with Trazodone, but not everyone will experience this side effect. Discuss concerns with your doctor.

Is it safe to take Trazodone with other medications?

Always inform your healthcare provider about all medications you are taking to avoid potential interactions.

Can I stop taking Trazodone on my own?

Do not stop taking Trazodone without consulting your doctor, as they can guide you on how to do so safely if needed.