Active Ingredient

Ursodiol

Ursodiol is a bile acid used in the management of certain liver and gallbladder conditions. It helps improve liver function and dissolves certain types of gallstones.

This medication is often prescribed to patients who cannot undergo surgery or to those with specific liver diseases.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Available Ursodiol Brands

Actigall

Strengths 150mg, 300mg

Ursodiol Uses

Ursodiol is typically used for the treatment of liver and gallbladder-related conditions. It is beneficial in managing:

Primary biliary cholangitis, a chronic liver disease.
Prevention and treatment of gallstones.
Improving liver function in certain liver disorders.

How Ursodiol Works

Ursodiol works by reducing the production of cholesterol in the liver and by dissolving cholesterol in bile. This process helps to dissolve cholesterol gallstones and improve bile flow.

It alters the composition of bile, making it less likely to form stones.

By doing so, it can help improve liver function and reduce liver damage in certain conditions.

Common side effects of Ursodiol

While not everyone experiences side effects from Ursodiol, some may occur. They are usually mild and temporary.

Nausea
Diarrhea
Constipation
Indigestion
Dizziness
Back pain

If you experience serious or persistent symptoms, contact your doctor.

Take Ursodiol with meals to enhance absorption and reduce stomach upset.
Avoid excessive alcohol consumption while taking this medication.
Inform your doctor about any other medications you are taking to avoid interactions.
Regular monitoring of liver function may be necessary during treatment.
Do not use Ursodiol if you have certain liver or gallbladder conditions without consulting your doctor.

Always consult your doctor or healthcare provider if you have questions about your treatment.

Frequently Asked Questions

What does Ursodiol do?

Ursodiol helps dissolve certain types of gallstones and improves liver function in specific conditions.

How long does it take for Ursodiol to work?

The time it takes for Ursodiol to work can vary. It may take several months to see the full effect on gallstones.

Can Ursodiol be taken with other medications?

Ursodiol can interact with other medications. It’s important to inform your doctor about all medicines you are taking.

Is Ursodiol safe for long-term use?

Ursodiol is generally considered safe for long-term use under medical supervision. Regular monitoring by your doctor is recommended.

Can I drink alcohol while taking Ursodiol?

It’s advisable to avoid excessive alcohol consumption while taking Ursodiol, as it can affect liver function.