does cialis lose effectiveness

Does Cialis Lose Effectiveness Over Time (When Using Daily or On Demand)?

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Cialis is a delightful drug that triumphantly broke into the market in the early 2000s, becoming an influential competitor to Viagra. However, there are no magic drugs, sometimes even the brightest stars of the pharmaceutical industry do not work for some patients (or lose their effectiveness).

Cialis is a drug that can be used on demand or on a daily basis (and in the case of daily intake, it often works better). For some men, it works well, but then reduces effectiveness. What can this be forced by? Let’s see.

Hormonal Problems

Hormonal problems, for example, a decrease in testosterone levels (the main male hormone responsible for masculinity and affecting libido), an impaired level of prolactin and some other hormones can worsen the effectiveness of tadalafil, the main active agent of the drug.

Studies conducted in recent years show that a drop in testosterone levels can lead to decreased performance, decreased lean body mass and increased body fat, elevated blood pressure and increased risk of developing heart disease, which in turn can adversely affect erectile function.

In these cases, the mechanisms for reducing erection are associated with libido, and Cialis-type medications cannot influence sexual desire. Treatment of hormonal disorders can normalize the effect of the drug.

Impairment of Cardiovascular Disease – Possible Cause

There is no evidence that Cialis can lose its effectiveness over time by itself. However, its effect may decrease if the cardiovascular condition that caused erectile dysfunction begins to worsen.

heart disease cialis

In this case, the problem is not in the preparation, but in the progressive disease. If you know that you have any heart disease that may have led to impotence, you should consult a doctor if you notice that tadalafil has not been working satisfactorily.

Causes may include poor control of high blood pressure (by the way, anti-ED drugs are contraindicated in case of uncontrolled hypertension), elevated cholesterol, and an increase in excess weight. Solving the problems underlying erectile disorder will have a positive effect not only on sexual health, but also on your heart.

Psychological Problems

The deterioration of the drug’s effect may be due to psychological problems with a partner. If there is coldness and misunderstanding in the relationship, sexual relations can worsen. In addition, some men may develop pronounced psychogenic problems that adversely affect the normal effect of the drug.

The most effective sex therapy is paired family therapy. In addition to sessions with a therapist, partners are required to complete homework in order to achieve positive results.

You might be interested: Is 20mg Cialis Equal to 100mg Viagra?

The Bottom Line

If Cialis stops working, you can try switching to another drug. But it is better to analyze the situation well and / or to make an appointment with a doctor in order to reveal the true cause of the malfunction. You may have experienced a more serious illness that requires treatment. Better safe than sorry…

female Cialis

Female Cialis: Does it Exist and Does It Work?

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In online pharmacies, Viagra for women (Female Pink Viagra) is gaining popularity. What about Cialis? Is there a female version of “The Weekend Pill”, a record holder for the duration of the action?

A Couple of Words about Cialis

These pills (officially produced by the American company Eli Lilly) are recommended for adult men suffering from erectile dysfunction. After taking Cialis, a man gets the desired effect under the conditions of sexual stimulation. The drug can be used on demand and on a daily basis. When applied on a daily basis, treatment may give improved effects over time.

Is Female Cialis Available Officially?

There are several drugs on the market for the treatment of female sexual dysfunctions. A few years ago, the American FDA approved flibanserin (G02CX02 (WHO)) for this purpose.

However, the usual male sildenafil also proved to be effective when used by women. Therefore, in online pharmacies you can find such drugs as Lovegra and Female Pink Viagra, which help to increase a lady’s excitement.

female cialis canada

Since tadalafil can also be effective in women, Indian companies have released the drug Tadafem. In fact, it is a copy of Lovegry (Viagra) with another active ingredient in the composition. Another drug that has tadalafil in its composition and is intended for ladies is a product called “female Cialis”. This drug is available in our online pharmacy, please find the appropriate section in the product range.

Declared Effects

The manufacturer of this drug claims that it affects the blood circulation, dilating blood vessels in some parts of the body. As a result, it provides an adequate flow of blood to the pelvic organs and increases the production of vaginal lubrication. In addition, the drug can potentially increase sexual desire, making the erogenous zones more sensitive to a partner’s touch. It should be noted that it does not directly affect libido as such, it simply improves the processes of arousal in the body.

How to use?

It is recommended to take Cialis 20-40 minutes before sexual intercourse. To obtain the desired range of effects, it is enough to take 1 pill. The medicine needs to be washed down with water. The maximum dosage per day is 1 tablet, it is better to take a longer break between successive dosages.

Contraindications

Like any other drug from the group of PDE5 inhibitors, female Cialis has contraindications:

  • allergy to any of the components of the drug (main or auxiliary);
  • serious diseases of the heart and vascular system, including uncontrolled arterial hypertension and severe arterial hypotension;
  • peptic ulcer in the period of exacerbation (open phase);
  • pregnancy, breastfeeding (in these cases, it is generally necessary to be very selective to any medication taken and always consult a doctor);
  • use of similar drugs, for example, Lovegra;
  • being under the age of 18 (minor);
  • serious kidney and liver disease;
  • post-surgery period.

In order to avoid the onset of uncontrollable effects and dangerous adverse events (such as very severe headaches, dizziness, a sharp decrease in pressure) it is recommended to follow the instructions drug use, that is, overdose is prohibited.

What Does the Science Say?

According to Borghi C and Dell’Atti L. (Archivio Italiano di Urologia e Andrologia, 2017), PDE5 inhibitors can be an efficient option for many subtypes of sexual disorders in females. Well-known vasoactive agents, especially tadalafil, showed satisfactory results.

As reported by Ashton AK and Weinstein W (Journal of Sex & Marital Therapy, 2006), females had derived benefit from using 20mg Cialis before anticipated coitus to reverse drug-induced sexual problems (without side effects).

female tadalafil

The Bottom Line

Thus, female Cialis really exists. The mechanism of its action is the same as that of female Viagra. But it works longer, providing more sexual spontaneity. However, female sildenafil may be more preferable for some women, as it acts for a shorter period of time, reducing the risk of adverse interactions with other pharmaceutical substances (if a female patient takes other meds). Remember that, as in the case of male anti-ED drugs, the female versions should in no case be combined with nitrates (nitroglycerin, etc.).

cialis or viagra

Is 20mg Cialis Equal to 100mg Viagra: Tadalafil / Sildenafil Doses Comparison

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It is known that the maximum dosage of the original Viagra is 100 milligrams of sildenafil. The maximum dosage of branded Cialis is only 20 mg of tadalafil. However, can these dosages of two drugs be considered equal in terms of the strength of the effect?

Viagra vs Cialis: What’s the Difference?

We’ve thoroughly analyzed these drugs and decided to highlight key factors of differentiation.

  • Producer. Genuine Viagra is manufactured by Pfizer Inc., a renowned American pharmaceutical company. Original Cialis is produced by Eli Lilly, which is also a US-based pharma giant. However, this difference is not determinative in case of generics. They are produced by less-known Indian, Canadian, and European manufacturers. We would not advise to buy generic drugs from China, as a risk to get a counterfeit is elevated.
  • Dosage. Viagra comes in three main dosages: 25mg, 50mg, and 100mg. There are four versions of Cialis: 2.5mg, 5mg, 10mg, and 20mg. As you can see, even the minimal dosage of Viagra (25mg) has less pharmaceutical substance than the maximal-dosed Cialis version (20mg).
  • Appearance. Viagra is supplied as a diamond-shaped blue pill while Cialis is sold in the form of almond-shaped yellow-colored pills. In case of generics, the difference may be another (depending on the product you choose).
  • Uses. Viagra and Cialis are both used to treat erectile dysfunction. In addition, other drugs with their active agents are used to fight pulmonary arterial hypertension. These are Revatio (sildenafil) and Adcirca (tadalafil). What is more, there are perquisites to assume that Viagra may be also used for urinary symptoms of BPH, however, there is no official approval for such a purpose.
  • Time of Action. Viagra works for 4-6 hours, in some males the needed effect may be observed within a 12-hour period. Cialis acts much longer (see below).

There may also be other differences, but they are not significant.

cialis 20 mg vs viagra 100 mg

What is the Key Feature of Cialis?

The main advantage of Cialis is an increased biological half-life of the active substance, which is approximately from 17 to 20 hours. Due to this, the desired effect is guaranteed within 36 hours after consuming the pill. As we have noted above, the maximum possible period of action of Viagra is only 6 hours (rarely 12 hours). Interestingly, this advantage is achieved without the use of a higher dosage of tadalafil.

For one and a half days, Cialis (or tadalafil) suppresses the production of PDE5 enzyme in the body, causing the cessation of erection. This drug, as well as Viagra, is a selective PDE5 inhibitor. What does it mean? Cialis blocks PDE5 (phosphodiesterase type 5) enzyme more actively, virtually not affecting the rest of useful PDE enzymes. For example, PDE3 is involved in cardiac muscle contraction, vascular smooth muscle and platelet aggregation. The effect of Cialis on this enzyme is 10 thousand times weaker than on PDE5.

Cialis 20mg vs Viagra 100mg: What’s the Best Choice?

These drugs belong to the same family – PDE5 inhibitors. They also have about the same efficiency: they work in 80-90% of patients with the highest possible dosage.

However, Cialis is believed to have either a more concentrated or more potent substance, so it contains a lower dosage than its main competitor.

However, Cialis 20mg and Viagra 100mg are almost the same in terms of improving erections. Some may get the best effect from Cialis, while others may prefer Viagra. But do not think that Cialis in the 20-milligram dosage is weaker than Viagra and vice versa.

You might be interested in the following article: Can you improve your libido using Viagra?

Conclusion

Thus, in terms of dosage strength, these doses can theoretically be considered identical. But at the same time, they cannot be fully equated. Cialis has a different half-life, which makes its action time six times longer than that of Viagra (sildenafil lasts up to 6 hours, while tadalafil provides the desired effect up to 36 hours). So choosing one or another preparation is generally a matter of taste. Administering other medications may also influence the choice, since Cialis lasts longer in the body, consequently, the period of possible harmful interactions with other drugs becomes longer.

Counterfeited Drugs

The Dangers of Counterfeited (Fake) Viagra

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Online pharmacies are a very convenient way to buy the necessary medicines, especially those for treating ED. After all, men value their privacy very much and do not want anyone to know about their problems. Unfortunately, the online pharmaceutical market offers many counterfeits that are associated with some health risks.

Counterfeited Drugs in Online Pharmaceutical Market

According to estimates of experts from international organizations, counterfeits account for 40% of the world pharmaceutical market. The WHO believes that on the Internet, part of counterfeit medicines can be up to 50 per cent. Experts say that counterfeiting of medicines has turned into the largest international underground business comparable in scale to drug trafficking, with the only significant difference that no one is insured against the threat of buying counterfeit drug, regardless of social status and income level.

In most cases, counterfeit medicines are not equivalent to the original drugs or generics in terms of quality, effectiveness, or side effects. Examples of counterfeits include widely used drugs, e.g. paracetamol, controlled substances such as human growth hormone, which is often illegally used in sports, and other types of drugs such as Viagra and Cialis. Viagra is counterfeited quite often, because it is a very popular medication among men suffering from erectile dysfunction. At the same time counterfeiters very skillfully forge the original medication. They give the tablet the same shape as original Viagra, put the same markings and offer medicines in the same package.

*Check our non-counterfeited Canadian Viagra: https://mycanadianhealthcaremall.com/product/viagra/

Pfizer’s Experiment

Several years ago, Pfizer Inc. (the developer of genuine Viagra) conducted its own investigation. Experts of this company bought Viagra from various sites, including suspicious ones, which claimed that they were selling the original Pfizer medicine.

Here is what they found in the counterfeited Viagra and other drugs:

  1. blue printer ink (counterfeiters have used it to give the tablets a blue color);
  2. amphetamines;
  3. Metronidazole*, an antibiotic that can cause gastrointestinal upset in large dosages;
  4. increased dosages of the active substance, which increases the risk of side effects and can cause harm to the body;
  5. binding agents, for example, drywall, which prevent the absorption of the tablet in the digestive tract;
  6. toxic substances, for example, road paint and rat poison, which can cause poisoning of the body and even lead to death;
  7. a completely different medication that has a different effect on the body and potential side effects.

*For more information about Flagyl ER (Metronidazole), please visit this page: Coming Soon!

Dangers of Counterfeited Viagra Use

There are several types of counterfeit medicines on the pharmaceutical market:

  • “Empty” drugs. They are usually not dangerous, but they do not give the desired effect. Counterfeiters add empty fillers to them and that’s it. Although in some cases they can work by analogy with placebo.
  • Medications that mimic treatment. They contain some active ingredients (for example, extracts of some plants), but these ingredients are cheaper and much less effective. They can have a curative effect, but they do not work as well as sildenafil (the basic component of Viagra).
  • Medicines with a low dose of active agent. The minimum dosage of Viagra is 25 mg, it is also available in 50 mg and 100 mg dosages. Some counterfeiters may decrease the dosage of the active substance. As a result, the medication may not work or exert a weaker effect.
  • Medications with increased dosage. It is not known why some scammers add more active substance than necessary. However, such counterfeits exist on the pharmaceutical market. They can have a stronger effect but their use is associated with a much higher risk of side effects.
  • Meds containing wrong ingredients. This is a dangerous kind of fakes when manufacturers add to the tablets cheap antibiotics or something else instead of sildenafil and other active substances. Such “medicines” can be dangerous to health because a person may have an allergy to the ingredients actually contained in a counterfeit medication. In addition, such products can cause unpredictable side effects and react unpredictably with other medicines.

Experts believe that all falsifications are potentially dangerous for health, since they are not subject to quality control required for legal medicines.

However, the most dangerous thing is when counterfeit medicines contain harmful chemical ingredients (examples of such ingredients have been described above). In this case, the patient will not only get the desired effect, but will also do harm to their health. So be very careful when buying Viagra on the Internet.

How to Avoid Counterfeits When Buying Viagra?

When you buy medicines on the Internet, evaluate the appearance of the website. Also, check if the site has an SSL security certificate and if there is a form for contacting the support service. In addition, it would not be superfluous to read reviews of users who have already bought medicines in this online pharmacy. If you see a kind of original medicine at a low price, it is most likely a fake. Legal generics do not claim that they are originals, they can have a different form.

By adhering to these simple rules, you can avoid fake Viagra on the Internet.

Another tip: you can get free samples of Viagra (Canadian Health Care Mall provides such an opportunity) and check their quality. If you are satisfied, you can order in this pharmacy in the future. My Canadian Pharmacy guarantees high quality of anti-ED medications.

Generic Drugs by Canadian Health&Care Mall

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You come to the drugstore with the prescription list, but instead of the preparation which is written out by the doctor with a famous trade mark or brand, the pharmaceutist offers you other medicine of similar appointment, explaining it to that your insurance pays only this “generic”. Thus he claims that meanwhile there is no difference neither in the mechanism and force of action, nor in side effects. It is clear that unexpected replacement causes some suspicions though there is in this situation and the pleasant moment namely generics cost significantly less. And this benefit because of prolonging prices increase becomes more noticeable.

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