buspar for anxiety

Buspar for Anxiety: Mechanism of Action, Dosage, Reviews

Anxiety disorders are the most prevalent psychiatric disorders in the world. Scientists have reported that these disorders may be underrecognized and undertreated. Treatment is necessary when a person experiences severe distress and/or complications associated with the disorder. Buspar has proved its efficiency in resultative fighting against anxiety.

Buspar’s Mechanism of Action

The main active ingredient of the drug is buspirone. This is an anxiolytic substance that differs in pharmacological properties from benzodiazepines, barbiturates and other sedative and hypnotic medical remedies. Studies have shown that buspirone has a high affinity for 5-hydroxytryptamine 1A receptors and a moderately pronounced affinity for dopamine D2 receptors in the brain. In simple words, Buspar affects chemicals that can be unbalanced in people with anxiety.

The effect of the drug occurs gradually; you will see the first results in 1-2 weeks. The maximum effect is achieved after 4 weeks.

Buspar does not cause addiction, it can be canceled without negative consequences for mental health. Patients cannot develop tolerance to this pharmaceutical substance.

busiron for anxiety

The drug helps to cope with the following diseases / conditions:

  • generalized anxiety disorder
  • vegetative-vascular dystonia, a type of dysautonomia, which affects vascular system
  • panic disorders
  • alcohol withdrawal syndrome (as a substituent of complex therapy)
  • depression (as an additional remedy in the therapy)

The use of Buspar leads to complete remission. However, withdrawal of the drug may lead to a return of symptoms.

The medication can cause a number of side effects, including restless legs syndrome (an uncontrollable urge to move the legs), dizziness, nausea, headache, and increased irritability. It is known that some patients with psychological / psychiatric disorders are prone to suicide. Fortunately, Buspar overdose is not enough to execute suicidal intentions. It is typically resolves with full recovery. However, as stated by Tyler K. Wilson and Jayson Tripp (StatPearls article, last updated February 2019), the risk of additional drug overdose exists, so relatives and healthcare experts should also investigate if a patient has administered extra medications.

It is important: the drug is not intended to treat anxiety symptoms caused by everyday stress or a stressful situation. In such cases, regular rest and herbal remedies will help to overcome the problem. Therefore, if you are simply very tired at work and have experienced stress due to bad words of your boss, do not take Buspar. It is intended for more serious cases.

Buspar Dosage, Features of Use

It is usually recommended to start therapy with 15 mg twice a day. Every 2-3 days, increase the dosage by 5 mg / day, until the desired effect is achieved, which should appear in the period up to 14 days.

The maximum dose of the drug is 60 mg / day, an increase in dose is associated with an elevated risk of side effects. The usual therapeutic dose is 20-30 mg / day. The daily dose should be divided into 2-3 portions.

The product is offered in 5mg–30mg dosage range.

Eating food can slow the absorption of the drug in the gastrointestinal tract.

If the medication did not start working after the expiration of the expected “deadline”, you need to consult a doctor and choose another medical remedy, such as benzodiazepine or an antidepressant.

An interesting stuff: Erectile Dysfunction and Depression: Often Coexist but Can be Overcome

buspar reviews

Buspirone Reviews

There are many negative reviews about buspirone on the Internet, but such a situation this is often due to the fact that people do not have the patience to administer the pills for a long period (as mentioned above, it takes 1-2 weeks for the effect to occur) or simply they don’t have proper information about Buspirone administration. Other people write on forums that the medicine reduces sociopathy, increases interest in various activities. For some, a work phone call to another person is an excruciation, but dissolving the tablet eliminates the problem.

zetia high cholesterol

How Does Zetia Work? Short Overview of this Lipid-Lowering Agent

Coronary heart disease (CHD) is one of the dominant causes of deaths in adults in the United States. CHD is linked to elevated levels of “bad” cholesterol and decreased rates of “good” chol. Proper treatment should include nutrition adjustments, physical exercises (at least long-lasting walking), and bodyweight loss. However, medication therapy may be a requirement.

Lowering Lipids in the Blood with Zetia

There are many medications that helps to decrease cholesterol in the bloodstream. Among them are bile acid sequestrants, statins, fibric acids, etc. However, there is a unique drug which is distinct from others. Ezetimibe (trade name Zetia) has no inhibitory effect on cholesterol production by the liver, it also doesn’t accelerate excretion of bile acid.

The medication localizes in the intestine and block absorption of cholesterol & some plant-based sterols. Ingestion of high-fat food has no influence on the bioavailability of Zetia (but this doesn’t mean that you can overeat French fries, burgers, cheese and other food with high content of fat, scroll down to know why).

Healthcare specialists typically prescribed Zetia (and clinical studies are also centered on the combination therapy), but monotherapy is also possible. According to the UK scientists Daniel Hammersley and Mark Signy (Western Sussex Hospitals NHS Trust, 2017), one-type treatment may be applied in the following cases:

  • treatment of primary hypercholesterolaemia in persons with contraindications to statin administration
  • hypercholesterolaemia in folks who cannot tolerate statin pharmaceuticals

Effect of Ezetimibe: Scientific Data

IMPROVE-IT trial performed by dozens of investigators and 2574 collaborators (published in 2015) showed Zetia substantially decreased incidence of severe cardiovascular events in people with cardiovascular diseases and low rates of “good” cholesterol. Moreover, incremental decreasing of cholesterol to rates below previous targets which were measured by doctors provided extra benefits.

According to American researchers Jigna Patel and others (Baylor University Medical Center, 2003), coadministration of Zetia plus lovastatin (Mevacor) showed greater effectiveness than lovastatin alone or ezetimibe alone. The combotherapy provided −39% reduction, while lovastatin monotherapy caused −25% decrease and Zetia led to just −19% reduction.

Hence it can be concluded Zetia provides less pronounced effect when used as monotherapy. Conjunction with statins is more efficient, however, this option may be unsuitable for some individuals.

When Is Zetia Contraindicated? What Are Potential Side Effects?

The medicine has high safety profile and is usually well-tolerated in different subgroups of patients. Nonetheless, as in case with any pharmaceutical product, Zetia has several contraindications, including:

  • increased sensitivity to principal or auxiliary components (fillers) of the drug
  • moderate of severe liver insufficiency
  • active liver disease (when combined with a statin medication)
  • pregnancy or breastfeeding (in combination with statins)

Sometimes, patients may experience side effects:

  • liver damage and disorders (especially when the drug is coadministered with statins)
  • muscle pain
  • weakness and tenderness
  • allergic reactions, such as itching, rash, dizziness, and trouble breathing (allergy is rarely observed)
healthy diet for cholesterol

Is It Enough for Successful Treatment?

No, just taking Zetia is not enough for adequate therapy of increased cholesterol. Before starting treatment, patients should switch to an appropriate hypocholesterolemic diet and adhere to this diet during the entire period of therapy. The diet should be based on the following principles:

  • limiting fried food
  • choosing low-fat milk and dairy products
  • eating more fruits and vegetables
  • consuming whole-grained food, poultry, lean fish, nuts and beans
  • curbing soft beverages and sugary food

In addition, scientists have revealed food and food supplies with hypocholesterolemic effects. As stated by Ruitang Deng (University of Rhode Island, 2009), these include fiber or polysaccharides, soy protein, phytoestrogens, and probiotic bacteria (it was claimed that additional studies are needed to evaluate efficacy and safety of probiotics and anti-cholesterol agents).

A related topic by Canadian Health&Care Mall experts: Treatment Diabetes and Overweight

zyban quitting smoking

Zyban for Quitting Smoking: How Does It Work? Can It Help to Boost Libido?

According to The Centers for Disease Control and Prevention (CDC), a total of approx. 15% of the US adults smoke (as of 2015), however, the prevalence of smoking decreased by 20% compared with a decade earlier.

The decline in smoking prevalence is understandable: more and more people realize that this habit is very detrimental to health and can even lead to death (due to lung cancer or another disease that has developed with tobacco use). Not all smokers can quit on their own, as this addiction is addictive. However, modern medicine offers effective and safe drugs that make smoking cessation easier. Zyban is one of these medications.

What it Zyban?

zyban tablets

The main component of the drug is bupropion hydrochloride. It was originally developed and came on sale as an antidepressant. Burroughs Wellcome obtained the patent in 1974, and in 1985 bupropion was approved for medical use. This pharmaceutical product soon proved effective in treating nicotine addiction. In 2007, doctors prescribed bupropion 20 million times, making it the fourth most commonly prescribed antidepressant drug in the United States after sertraline (Zoloft), escitalopram (Lexapro), and fluoxetine (Prozac).

This quit aid is nicotine-free, but it can be used in combination with nicotine replacement therapy (NRT). Studies have shown that such a conjunction improves chances for long-term success after smoking cessation.

Zyban should not be used amidst the following circumstances:

  • administration of any bupropion-containing drug
  • seizure disorder (currently or in the past)
  • eating disorder (currently or in the past)
  • use of monoamine oxidase inhibitors
  • allergic reactions to bupropion
  • gestation, nursing, and some others

What’s the Mechanism of Zyban’s Action?

The active substance of the drug affects the mechanisms in the brain that are responsible for the occurrence of pleasure. As an antidepressant, Zyban replaces the “pleasure hormone” that is released intensively during smoking, as nicotine becomes less effective in the brain. This allows the patient to reduce the degree of discomfort for a period while quitting smoking. Usually a person completely quits smoking within 7-10 weeks of using the drug (but the results may vary depending on the degree of dependence). As the results of numerous studies show, the administration of this medicine avoids many of the negative effects of nicotine addiction, including anger, anxiety, anxiety, depressive disorder, feelings of frustration, and irritability.

Smoking is a well-studied risk factor for a multitude of chronic diseases, especially cardiovascular ones. In the worldwide structure of causes of death, cardiovascular illnesses make up the majority. Smoking is also the cause of severe diseases of the respiratory, digestive and other systems. The lion’s share of the causes of malignant tumors is attributable to tobacco abuse.

dangers of smoking

Can Zyban Help to Boost Libido?

Yes, it can but indirectly. Sure, it contains no substances that might directly improve blood flow in the genital area. It is known that quitting smoking helps to restore erectile function in males, because its functionality depends on the condition of the cardiovascular system. Iranian scientists from Tehran conducted a special study “Do cigarette smokers with erectile dysfunction benefit from stopping?” in 2004. They reported that there was an ED improvement in a considerable proportion of former smokers. A more recent study by scientists at Baylor College of Medicine and Urology of Indiana (2015) contains more precise results. Researchers reported that men under 50 are more likely to restore erectile function (by quitting cigarettes and tobacco) than those who have crossed this age mark. This might due to the fact that at an older age, many other factors affect the state of erection.

A related article: Can You Improve Your Libido Using Viagra?

Therefore, using Zyban you can improve your erection and have better sex. In addition, you will receive many other health benefits associated with quitting smoking (the main one is reducing a risk of cancer). So don’t delay if you’re interested, order the medication for an affordable price.

nexium gastritis treatment

Gastritis Treatment: Nexium (Esomeprazole) vs Natural Remedies

Chronic gastritis is the most common condition of the gastrointestinal tract, according to some data, its prevalence may reach 60%. Fortunately, there are many powerful remedies that can help to overcome it. Nexium is one of them. It is significantly inferior to omeprazole in terms of popularity, however, it is still widely used. How does it treat gastritis? What’s better: Nexium or natural remedies?

Gastritis, Its Causes and Symptoms

Gastritis is a general term covering a group of illnesses that have one common feature: inflammation, irritation or erosive lesions of stomach lining. According to some authors, gastritis is more likely a condition and not a disease, since in many cases inflammation of the gastric mucosa does not lead to the appearance of clinical symptoms.

Gastritis development may be linked to Helicobacter pylori, frequent/permanent psychoemotional stress, personal problems, improper nutrition, harebrained fasting, alcohol overconsumption, smoking, cocaine, severe illness, autoimmune disorders, using an anti-pain medicine (NSAID) for an extended period, eating dry food and some other causes.

Related topic: Diclofenac for Pain Relief

Some scientists consider the term “gastritis” inappropriate, since a serious mucosal lesion can be almost asymptomatic, while gastrointestinal upsets such as pain, nausea, belching, and loose stools can occur with a slight inflammation of the stomach or even in its absence. If there are no structural changes in the gastric mucosa, the diagnosis of functional dyspepsia can be used. In Japan, a country with a very high rate of stomach cancer (the incidence in men is 77.9 and in women 33.3 per 100,000 population), doctors combine the diagnoses of chronic gastritis and functional dyspepsia, thereby indicating the presence or absence of mucosal changes gastric lining and / or related clinical symptoms.

The most common cause of chronic gastritis worldwide is H. pylori infection. This bacterium causes progressive damage to the gastric mucosa and plays an important causative role in a number of important diseases, including duodenal ulcer, gastric ulcer, and even stomach adenocarcinoma (a type of cancer).

Well, what are symptoms of gastritis? The most common ones are as follows:

  • heartburn
  • pain in the abdominal area
  • appetite decrease or loss
  • nausea
  • hiccups, especially after eating irritative food
  • dyspepsia (indigestion)
  • stomach upset
  • dark stools

What is Nexium? How Does It Work?

A pharmaceutical substance called esomeprazole was patented back in 1993, however, it received approval for medical use only 7 years later – in 2000. It is now available as a non-branded (generic) medication and sold OTC in many countries. According to ClinCalc, it was 69th most prescribed medication in the United States (but its position slightly worsened in comparison with the previous year). Branded name of the product is offered by AstraZeneca company.

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The drug comes in the form of delayed-release tablets or delayed-release capsules. It also has enteric coating, as the active substance is actively destroyed by the stomach acid. There two typical dosages: 20mg and 40mg.

Nexium can be ordered here: Product page.

The medication belongs to the category of medications called proton pump inhibitors (PPIs). They have similar mechanism of action. Like other PPIs, Nexium works by reducing the amount of gastric acid made by the stomach. Therefore, stomach mucosa receives a possibility to recover from damage caused by acidic gastric juice.

An important fact: stress-induced gastritis can be prevented by early use of PPIs. Rishi Megha and Peter P. Lopez, StatPearls Publishing, 2019.

The medication work best when used on a regular basis. Try to take it at the same time every day. Continue the administration till the end of prescribed period, even if you feel improvement of your symptoms. Sudden cancellation can lead to a quick return of the condition. Tell your healthcare provider if your condition worsens or does not improve. Important: this medication is very similar to omeprazole (Prilosec, Losec), so don’t take omeprazole-containing medicines while treating with Nexium.

Natural Remedies for Gastritis Treatment

Besides medical therapy, a patient should take attention to natural methods of gastritis treatment. Let’s consider main of them.

gastritis diet

Proper Diet

Doctors say that diet is a cornerstone of successful gastritis treatment. The main rule: food should not be very acidic, salty and bitter. It should be gentle and not irritate the gastric mucosa, so coarse and hot food is also contraindicated, especially when the disease is in exacerbated phase.

If you suffer from gastritis symptoms, you can eat porridge (cereals), soups, lean meat and fish, boiled vegetables, non-acidic fruits. Drink non-carbonated and non-caffeinated drinks. Dairy products, sweets, gluten-containing foods can contribute to inflammation.

Herbs and Plants

Some herbs may help to combat gastritis. These include green tea, rosemary, aloe vera, chamomile, calendula, thyme, lemon balm, and mint. Don’t choose herbal teas on your own, always consult a healthcare professional. Some of them may increase gastric acidity, while others, vice versa, may decrease it. Depending on the type of disease you have, an effect may be inappropriate.

Jelly prepared on the basis of flax seeds is considered a useful remedy. It “wraps” the gastric mucosa, positively affecting its condition. Other folk remedies include cabbage juice, honey, coconut oil and water, turmeric, juice from carrots and potatoes.

natural treatment of gastritis

Supplements

There are several over-the-counter supplies that might be helpful in case of gastritis. Among them are chlorophyll, essential oils, probiotics, and garlic extract. Supplements are sold as OTC products; despite that it would be a good idea to consult a healthcare expert before the beginning of self-prescribed therapy.

Nexium vs Natural Treatment

When it comes to comparison between these two methods, it should be said that Nexium may act quicker and be more effective. Natural herbs may take longer time to show necessary effect. However, the proper diet is a must-follow thing in any case, without it your efforts will be in vain.

How Long after Taking Cialis is it Most Effective

How Long after Taking Cialis is it Most Effective?

Cialis is prescribed for treating erectile dysfunction (ED). It’s commonly called a “weekend pill” due to an unbelievably prolonged duration of its activity, which lasts on average 36 hours. Such long-lasting action (if you take it before sexual act) is one of the longest compared to other medicines against problems with erection.

The Impact of the Medication

Tadalafil is manufactured under brand name Cialis. Tadalafil provides blocking of enzyme’s action, which is also called as cGMP-specific phosphodiesterase type-5 (PDE-5). cGMP is a component, which stimulates the relaxation of smooth muscles. The enzyme breaks cGMP down. If PDE-5 is blocked the cGMP’s levels are increased. Consequently, smooth muscles relax and blood vessels get wider (this process is known as a vasodilation).

cialis action

Enhanced amount of PDE-5 is common for such organs as lungs, retina and penis. It is presented in a minor quantity in blood vessels’ smooth muscle cells and muscles.

The Maximal Efficiency of Cialis When Taken as Needed

cialis effectiveness

The highest rate of Cialis concentration in plasma is observed from half an hour to 6 hours after (average time is 2 h) taking the necessary dosage. The required effect of the drug last approximately 36 hours, which is especially appreciated by the patients.

The medicine is allowed to be consumed for a long period. According to the study of the Italian scientists Montorsi F, Verheyden B, Meuleman E and others (held in 2004) Tadalafil in doses from 5 to 20 mg per day for 18 or 24 months is completely safe and greatly tolerated.

Read more: Does Cialis Lose Effectiveness Over Time (When Using Daily or On Demand)?

Key points:

  • Alcohol beverages (especially in huge quantities) are not recommended to be combined with Cialis, since they minimize blood pressure and lower sexual performance.
  • Specialists don’t recommend to eat grapefruit during therapy with Cialis.
  • Consult licensed healthcare specialist before trying any drug for ED to avoid severe side effects, which may occur in men with some medical conditions.
  • Immediately visit your doctor in case of feeling dizziness, painful sensations, nauseous during sex, tingling in arms, jaw, neck or chest, numbness.
  • It’s prohibited to mix Cialis with drugs, based on nitrate (for instance, nitroglycerin, isosorbide dinitrate/mononitrate) in case of chest pain and heart conditions. Taking Cialis together with recreational medicines (for example, “poppers”) can lead to the sudden and dramatic drop in blood pressure.

When Does the Peak Action of The Drug Take Place With Daily Usage?

There is a version of medicine which has to be taken in small dosages. That is why everyday usage is allowed. This property of Cialis allows you to have sex whenever you desire. Most anti-ED medications are taken at certain time, not daily, which isn’t convenient for patients, who want to enjoy sex constantly.

Cialis (daily) may show its effect not immediately after taking. The organism may require several days to get used to the medication.

You should start the therapy with 2.5 mg. If no evident changes happen, the dose should be increased to 5 mg. Keep in mind that men who take Cialis everyday are at risk of facing rapid lowering of blood pressure in case they drink a lot of alcohol.

taking viagra cialis every day

Is it Ok to Take Viagra or Cialis Every Day?

Viagra and Cialis are usually administered on demand, that is, a person takes a pill when he plans to have sex in near time. Sometimes, people need to take these tabs every day. Is it ok? Are there any health risks?

Everyday Use of Viagra

Theoretically, one can use Viagra on an everyday basis. However, in practice such cases are not very frequent as not everyone (especially after 40, when prevalence of ED begins to rise) has sex every day. Moreover, some reported occasions of blindness which may be associated with prolonged administration of sildenafil may play a role of a preventive factor despite the fact that direct link between its use and hearing impairment hasn’t been established. Moreover, sildenafil is an active component of Revatio drug. Doctors prescribe it for treating pulmonary arterial hypertension, and patients need to take it every day. So we can conclude that “blue diamond” with the same sildenafil in composition is safe when taking on an ongoing basis.

FYI: professional article “Can You Take 2 Viagra Pills at Once? Is It Safe?”

At the same time, the medication doesn’t cause tolerance worsening. According to the study by James G McMurray et al. (Medical Affiliated Research Center, Pfizer Inc. etc., 2007), most of participants who had used the medication for a long time responded affirmatively when the surveyors asked them about successfulness of erectile dysfunction treatment. This means that durable administration of Viagra doesn’t cause loss of tolerability, it maintains the same effectiveness.

Conclusion: Viagra can be taken every day, that would be ok for your health. However, if you practice daily using (especially in high dosages), it is recommended to consult a healthcare professional.

Administration of Cialis on Daily Basis

Well, it depends. There are two recommended modes of taking Cialis. The first one is taking it on demand (as needed). Considering the fact, that tadalafil acts up to 1.5 days (36 hours), its administering on an everyday basis may be associated with increased risk of side effects as the substance just doesn’t have time to leave the body in full. Two pills are stacked, and the concentration of tadalafil in the blood remarkably increases, causing semi-overdose condition.

The second mode is daily treatment. A male can take low doses of Cialis (2.5 or 5 mg) every day, preferably at the same time, say 12 am. Such treatment can last long. It features the great advantage: there is no need for a patient to plan sex at all, he can have it anytime, as the active substance remains in the body on a permanent basis. This regime can bring more romanticism in a couple’s relationship.

You might be interested in: Is 20mg Cialis Equal to 100mg Viagra?

Interestingly, Cialis in minimal doses can treat benign prostate hyperplasia (prostate adenoma, BPH in short). Moreover, according to Konstantinos Hatzimouratidis (Hellenic Aristotle University of Thessaloniki, 2014), this is the only pharmaceutical product that can successfully treat both BPH and ED, because traditionally used medications for reducing urinary tract symptoms, including α-adrenergic antagonists and 5α-reductase inhibitors, are associated with sexual adverse events and may worse impotence.

Conclusion: Cialis in low dosages (2.5 mg or 5 mg) can be used daily, this has been officially allowed. If you take higher dosages (10 mg or 20 mg), time interval between doses should desirably be 36 hours.

Takeaways

Both Viagra and Cialis can be taken every day. But you can do that only if there is a real need. Plus, in case of Cialis you need to use the lowest dosage.

generic viagra manufacturers

Generic Viagra Manufacturers: Companies that Produce Sildenafil Drugs

Viagra is one of the most known pills in the world. However, its branded version, to put it bluntly, is not cheap. Fortunately, there is a widely accepted scheme according to which, when a patent for an original medication expires, other pharmaceutical companies (which are eligible to do this) acquire the right to manufacture an unpatented drug (generic). After appearance of generic products, original Viagra sales didn’t nosedive but remarkably decreased. Such a situation even forced Pfizer to announce the launch of its own generic product line. However, other drugmakers managed to earn fame, so now their drugs are very popular.

Well, do you want to know exactly which companies produce generics of Viagra? Then this article is for you.

Indian Drugmakers that Produce Sildenafil Generics

India is the biggest generic supplier in the world. Many companies producing generics of different kinds are based in Indian jurisdiction (examples are Cipla and Dr. Reddy’s). Such a position of India is associated with favorable conditions for pharmaceutical companies’ operating, relatively low salaries for workers, and some inapproachability with regard to patents’ action and lawsuits of genuine products’ manufacturers. Indian medicines are often sold over-the-counter.

Read our article: Over-the-Counter Viagra.

Ajanta Pharma

ajanta pharma kamagra

Ajanta Pharma is a specialized pharmaceutical company engaged in the development, production and marketing of high-quality medicines in both the Indian and international markets. This company was founded in 1973 with headquarters in Mumbai-India. Thus, this company has extensive experience (over 40 years) in manufacturing medicines. Ajanta consistently provides high quality affordable medicines for patients in different parts of the world. Recently, it has focused its production on exports and on the final Western consumer, in particular, tablets of this manufacturer are widely advertised in Europe (although they are not approved in all countries).

Ajanta Pharma is probably the most known producer of generic sildenafil, as this company produces Kamagra, Kamagra Jelly, and Kamagra Super. Let’s take a brief look at these preparations:

  • Kamagra is an ordinary sildenafil. Unlike genuine Viagra (the so-called “blue diamond”), this drug has turquois color. The most popular dosage is 100mg, but 50mg is also sold.
  • Kamagra Jelly. This is a unique remedy which is marketed in a gel form contained in sachets. It features various flavors such as banana, mint, strawberry, pineapple, orange, chocolate, cream, mango, rose and a few others.
  • Kamagra Super. This is a combination of sildenafil (an anti-ED agent) and dapoxetine, a substance which helps to handle premature ejaculation.

Sun Pharmaceutical Industries Ltd.

Sun Pharma was incorporated back in 1983. Initially it sold psychiatric products (five medications). In 1994 it launched IPO (Initial Public Offering). After parabolic growth, it expanded the network of drugs’ sale across more than 20 counties. Regarding innovative activity of the company it’s worth mentioning that it introduced gastroenterology products in India (in 1989).

This company produces, in particular, Caverta medication. It is interesting that earlier Caverta was produced by Sun Pharmaceutical Industries Ltd, but on 25th March 2015 Sun Pharma completed the acquisition of Ranbaxy Laboratories, so nowadays Ranbaxy actually doesn’t exist as a separate firm being an integral part of Sun.

In addition, according to the information on the company’s official website, it offers sildenafil in different dosages under the name RAN SILDENAFIL.

Centurion Laboratories

Centurion Laboratories is one of the largest generic manufacturing plants located in India. Centurion Laboratory produces more than 100 types of generics, from simple drugs, sedatives, drugs for the treatment of erectile dysfunction to serious anti-hepatitis, anti-tuberculosis, and anti-cancer drugs. Centurion Laboratories Pvt. was founded in 1998 in the city of Guyarat. In 2017, the company’s turnover amounted to more than $5 billion.

Centurion Labs produces several names of Viagra generics, in particular, Eregra and Cenforce. In addition to generic sildenafil, the company also manufactures generics of other PDE5 inhibitors, as well as drugs for the treatment of premature ejaculation, and natural remedies for the treatment of impotence.

Ranbaxy

Ranbaxy Laboratories Limited is the largest pharmaceutical corporation in India, a multinational manufacturer of a wide assortment of medicines.

Ranbaxy was established in 1961. In 2008, it entered into an alliance with one of the biggest Japanese innovative businesses, Daiichi Sankyo Company Ltd. As a result of this merger, the major player in the market of innovative and generic drugs emerged. The combined company today is among the 20 largest pharma behemoths in the world. In particular, it produces supplements (for example, iron-containing ones), antibacterial drugs, drugs for treating hypertension, medicines for men’s health, and many others.

The most known generic drug manufactured by Ranbaxy is Caverta.

Cipla

Cipla Limited is an Indian multinational pharmaceutical and biotechnology company, headquartered in Mumbai, India. Its production facilities are located in Belgium, Surrey in the EU, Miami, Florida in the United States, as well as in other countries. The company specializes in the production of drugs for respiratory, cardiovascular diseases, arthritis, diabetes, erectile dysfunction, and other conditions. It was founded by the Indian nationalist and scholar Khwaja Abdul Hamied back in 1935 in Mumbai. The products of this Indian corporation are approved by the American FDA.

Sipla produces a medication which is called Silagra. Another less-known generic is Assurans (in a tableted form).

Other Manufacturers

There are also other Indian companies less preeminent than the abovementioned ones. These are FDC (Zerect tabs), Medley (Vigreks tab), Bestochem (Rocky-50), Human Pharmacia (Sex-Gra), Dr. Reddy’s Lab (Rezum), Dynamic (Ratigra), Protec (Progra), Zydus Alidac (Penegra), Kopran (Nyte tab), Unichem (Erix), Torrent (Androz), IND-SWIFT (Adams Delite), and a bunch of others.

Canadian Companies Manufacturing Generic Viagra

Canada is considered a world leader by a quantity of online pharmacies which are based in this country. But in fact, in this country there are no many manufacturers producing Viagra generics comparing, for instance, with India.

Teva

Teva is one of the world’s leading manufacturers of generic drugs, which is among the 15 largest international pharmaceutical manufacturers. In addition to a wide selection of high-quality generics in such areas as cardiology, pulmonology, oncology, neurology and urology, the company also produces its own innovative medical products.

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Teva is a company originating from Israel (its earliest predecessor was Jerusalem-based “Salomon, Levin, and Elstein Ltd.”). But it has multiple affiliated firms in different companies of the world, in particular, in Canada. Sildenafil Teva is a recognizable drug among many patients.

Pharmaris Canada

Pharmaris Canada is a young company, whose activity began in Peru in 2009 with subsequent expanding to other countries (Peru, Chile, Canada, and others). The Canadian branch is based in British Columbia.

Pharmaris Canada manufactures PRZ-Sildenafil medication.

It should also be noted that Mylan, a widely known pharma company, has launched sales of generic Viagra in 11 countries. But Canadian facilities of this corporation most probably don’t produce this medication, and it is not offered by Canada-based drugstores.

Mexican Drugmaking Companies

According to statistics, the United Mexican States is one of the largest markets for erectile dysfunction products (both pharmaceuticals and herbal products).

You might be interested in: Natural Alternatives to Viagra – Do They Really Work?

In addition, Mexico is famous for its producers of anabolic steroids, which are (although in Mexican pharmacies some anabolics may be bought without a prescription). Keep in mind that some of medications sold in this country may be counterfeited, this applies not only to anabolically active drugs but also to other kinds of meds, including Viagra.

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Besides semi-legal and underground manufacturers, Mexico is a base for many giant pharmaceutical corporations which have opened affiliate companies there. For instance, these are local branches of Schering Plough, Boehringer Ingelheim, Bayer, AztraZeneca, and GlaxoSmithKline.

In Mexico, there is also a branch of Pfizer company. It is interesting, that in 2011 Pfizer launched a special version of Viagra in Mexico. This was Viagra Jet (“Tabletas Masticables”), a chewable medication for males who didn’t like swallowing pills or capsules (but it is not known whether this version is sold nowadays). However, males may simply choose Kamagra Jelly.

Which Dosages Are Offered by Generic Viagra Manufacturers?

Of course, generic drugmakers offer classic dosages of Viagra, that is 25mg, 50mg, and 100mg. However, other variations are also possible. Sometimes you can find enhanced doses, like 150mg and 200mg. Some males can take advantages from increased quantity of sildenafil in the chosen product, but keep in mind that an increase in dosage does not necessarily mean improvement of the medication’s effectiveness.

Conclusions

There are a lot of generic Viagra producers on the market. But the key thing for a customer is not the choice of a manufacturer (as manufacturers don’t sell medications directly to users), his task should rather be finding a reliable supplier. Read more: Why is Canadian Health&Care Mall the Best Way to Order Generic Drugs?

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How to Take Levitra: 3 Useful Recommendations

Levitra is a drug for treating impotence in men. This is one of the most proven and effective sexual enhancers that can overcome the problem of impotence from the very first dose. The original version of the drug was developed by German specialists, but nowadays generic versions of Levitra (Canadian, Indian) are produced by many pharmaceutical companies.

Often it is not enough to just take a drug, if you want it to act properly, you should follow some rules. Males who suffer from ED may wonder: how to take Levitra to achieve maximum possible effectiveness?

Why Might You Prefer Levitra?

The most popular ED medication in the world is Viagra. It is known as a preeminent brand, so its sales are still high despite the existence of many competitors on the market. Cialis is probably the most known competitor of the “blue pill” which acts remarkably longer than Viagra. Its duration of effect is 36 hours, while Viagra feature only 4-6 hours. Well, Levitra acts for 4-5 hours. But nevertheless it has decent popularity (especially in some European countries). We believe that there are two reasons for this.

  • The first one: Levitra is more efficient in patients suffering from diabetes mellitus which often coexists with impotence because it is one of causative factors of sexual weakness (due to diabetes-caused deterioration of the blood circulation).
  • The second reason: Levitra might be effective in males who haven’t experience proper effect. According to some reviews, patients have tried different ED meds and herbal supplies but only Levitra brought the expected effect.
how to take levitra tips

How to Take Levitra Tablet: Must-Know Tips

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  1. It is recommended to take Levitra swallowing the pill down with water. Using other fluids isn’t advised because it is not clearly known how they may interact with the pill’s covering and internal ingredients. There are no reports about dangerous interactions, for example, with milk, but better follow instructions. (Recently we analyzed how to take Viagra: with water or milk.)Moreover, scientists have proven than grapefruit juice may lead to unsafe interactions, as this fruit contains a substance which inhibits an enzyme ensuring proper removal of toxins and pharmaceutical substances from the body. As a result, a concentration of vardenafil in the blood may become iffy.
  2. The medication can be taken with food (while you eat), but don’t combine it with high-fat or heavy meal, as this may slow down absorption of the drug, and the onset of effect will be observed later than expected (the medicament usually starts to act 25-60 minutes after ingestion). Levitra works best when taken on an empty stomach, which has been confirmed by patients’ reviews.
  3. Wait about an hour before having sex. If you take Levitra, it may be better to plan your sex in advance, as the peak concentration of vardenafil (the key active substance), and, subsequently, the maximum effectiveness is shown 1-2 hours after using. Then the efficiency of the medical remedy begins to decrease, slowly but surely.

Safety Precautions

  • If you take any medications, herbal/dietary supplements, let your doctor know about that. The medication may dangerously interact with some other drugs (for instance, nitrates, erythromycin, ketoconazole) and supplies (like L-Arginine). Better safe than sorry. Healthcare professionals also recommend to avoid St John’s Wort, a natural remedy for depressions, if a patient takes Levitra or other PDE5 inhibitors.
  • Discuss your medical history (anamnesis) with a healthcare professional. While general conditions like cold, flu, mild gastritis etc. usually don’t matter, cardiovascular diseases may be factors that prevent Levitra administering. For instance, it is contraindicated to take the tablet if you’ve recently had stroke or another cardiovascular event. The same goes for situations when a patient and/or someone from his family has a history of degenerative ophthalmic diseases.
  • The maximally allowed dosage of Levitra is 1 pill per day. Don’t take more than 2 pills within a 24-hour period, this may be associated with elevated odds of side effects occurrence.
  • Don’t combine the medicament with other drugs from the family of PDE5 inhibitors (Cialis, Levitra, Stendra, etc.). Chances to receive a boosted (synergetic) effect are improbable, but the risk of side effects definitely increases.
  • It is desirable to avoid alcohol or at least minimize its consumption when you are treated with the pill. Alcoholic drinks in huge quantities tend to decrease Levitra effectiveness, moreover, the cumulative action of ethyl alcohol and vardenafil may lead to arterial pressure drop resulting in headaches, weakness and even reluctance to have sex. Several glasses of whiskey in combination with Levitra can cause the opposite effect, not the one that you’ve expected.

Last but not least, you may use Levitra over a long period of time. This pharmaceutical product is not addictive, so prolonged usage pose no danger to your health (in terms of addictiveness). Some males may build up a tolerance to the medication, but such incidents are really rare.

does cialis make you bigger

Does Cialis Make You Bigger? Explanation of Positive Effect

Cialis is a potent anti-ED drugs and probably is the most serious competitor of Viagra (“blue pill”). It has been existing on the pharmaceutical market for 15 years. Its name is now associated with some myths and misbeliefs. Can it make the penis bigger? This question sometimes arise in patients’ minds. Let’s try to give a science-backed answer to it.

Active Agent of Cialis

There is a family of medications which are extensively used throughout the world to combat erectile dysfunction in males. These are PDE5 inhibitors (phosphodiesterase type 5 inhibitors). They have similar effects but also feature distinctive characteristics.

For instance, sildenafil is an active substance in Viagra which acts up to 6 hours, while Cialis contain tadalafil, the “champion” by the duration of action (up to 36 hours or 1,5). Cialis is available in several classic dosages: 2.5mg, 5mg, 10mg, and 20mg. If you are taking Cialis for the first time, you can start carefully with 5mg or 10mg pills, but the most commonly used dosage is 20 milligrams.

You might be interested: Is 20mg Cialis Equal to 100mg Viagra?

Does Cialis Make the Penis Bigger?

Well, yes and no. If a man is sexually excited and his body is under influence of Cialis, his organ will become bigger due to naturally occurring erection processes, which are just facilitated by tadalafil. In this sense, it can make erected penis bigger. But when it comes to physical growth of the penis (on a permanent basis), Cialis is helpless. It doesn’t contain hormonal substances and doesn’t activate growth processes in the penile organ. For this purposes, other means are used.

So What Exactly Does Cialis Do?

The active ingredient of Cialis exerts suppressive effect on PDE5, a natural enzyme which is present in the penis, lungs, and some other parts of the body. However, the medication has a high specifity and acts primarily on the genital area (but a special tadalafil-based drug, Adcirca, is used to treat pulmonary arterial hypertension).

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PDE5 suppression leads to a positive effect on a male erection. This is associated with the fact that phosphodiesterase type 5 inhibits cyclic guanosine monophosphate (cGMP) substance. cGMP is responsible for normal erection. Amidst the influence of Cialis, levels of cGMP in penile tissues are increased, which leads to relaxation of smooth musculature, which opens access for the blood flow to enter the organ. When penis is properly filled with blood, it acquires necessary hardness.

Moreover, tadalafil also leads to muscle relaxation in the prostate, urinary bladder and vessel which transports blood to these organs. That’s why it has been officially approved to treat benign prostate enlargement, more precisely, urinary symptoms caused by it. It is now a popular alternative to other established meds for these symptoms, such as α-adrenergic antagonists.

However, as K. Hatzimouratidis at the Aristotle University of Thessaloniki (Greece) rightly points out, it is not just a substitute, since side effects associated with the traditional medical remedies are avoided in case of tadalafil, plus, Cialis is the only medicament which is able to treat both erectile dysfunction and urinary unhealthiness simultaneously.

Like Viagra, Cialis don’t improve libido. Sexual excitement is a necessary requirement for Cialis’ onset of effect. If you wanna enhance your libidinal characteristics, try herbal remedies and adjust your diet (include watermelon, asparagus, walnuts, almonds, black chocolate, peaches, and shellfish).

The Bottom Line

Cialis has been shown to significantly improve the ability to achieve sexual intercourse. The medicine helps to trigger and maintain an erection by expanding the blood vessels leading to the penis and improving the blood flow. If there are no other physiological or mental problems in the background, it will definitely work. In case of psychogenic disorders, effectiveness may be lower but it usually still helps. However, it doesn’t help get bigger permanently.

does cialis lose effectiveness

Does Cialis Lose Effectiveness Over Time (When Using Daily or On Demand)?

Cialis is a delightful drug that triumphantly broke into the market in the early 2000s, becoming an influential competitor to Viagra. However, there are no magic drugs, sometimes even the brightest stars of the pharmaceutical industry do not work for some patients (or lose their effectiveness).

Cialis is a drug that can be used on demand or on a daily basis (and in the case of daily intake, it often works better). For some men, it works well, but then reduces effectiveness. What can this be forced by? Let’s see.

Hormonal Problems

Hormonal problems, for example, a decrease in testosterone levels (the main male hormone responsible for masculinity and affecting libido), an impaired level of prolactin and some other hormones can worsen the effectiveness of tadalafil, the main active agent of the drug.

Studies conducted in recent years show that a drop in testosterone levels can lead to decreased performance, decreased lean body mass and increased body fat, elevated blood pressure and increased risk of developing heart disease, which in turn can adversely affect erectile function.

In these cases, the mechanisms for reducing erection are associated with libido, and Cialis-type medications cannot influence sexual desire. Treatment of hormonal disorders can normalize the effect of the drug.

Impairment of Cardiovascular Disease – Possible Cause

There is no evidence that Cialis can lose its effectiveness over time by itself. However, its effect may decrease if the cardiovascular condition that caused erectile dysfunction begins to worsen.

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In this case, the problem is not in the preparation, but in the progressive disease. If you know that you have any heart disease that may have led to impotence, you should consult a doctor if you notice that tadalafil has not been working satisfactorily.

Causes may include poor control of high blood pressure (by the way, anti-ED drugs are contraindicated in case of uncontrolled hypertension), elevated cholesterol, and an increase in excess weight. Solving the problems underlying erectile disorder will have a positive effect not only on sexual health, but also on your heart.

Psychological Problems

The deterioration of the drug’s effect may be due to psychological problems with a partner. If there is coldness and misunderstanding in the relationship, sexual relations can worsen. In addition, some men may develop pronounced psychogenic problems that adversely affect the normal effect of the drug.

The most effective sex therapy is paired family therapy. In addition to sessions with a therapist, partners are required to complete homework in order to achieve positive results.

You might be interested: Is 20mg Cialis Equal to 100mg Viagra?

The Bottom Line

If Cialis stops working, you can try switching to another drug. But it is better to analyze the situation well and / or to make an appointment with a doctor in order to reveal the true cause of the malfunction. You may have experienced a more serious illness that requires treatment. Better safe than sorry…