viagra weight loss

Can Viagra (Sildenafil) Be Used As a Weight-Loss Drug: Research Data

Scientists have recently discovered one more property of Viagra, which is commonly used as a potency enhancer worldwide. The drug’s efficiency in treating erectile dysfunction (ED) and boosting sexual performance was approved by FDA in 1998. It stops the destruction of cGMP, which is a key regulator of blood flow in penis. Viagra contributes to proper blood supply to the men’s organ and provides excellent erection. That’s why it’s so popular with male patients who suffer from impotence.

Viagra’s Action Isn’t Limited: Fat-Melting Effect Explained

But now it’s also considered as an accelerator of the weight loss. The medication, despite its main function, converts excess fat cells, alerts resistance of insulin, and diminishes other complications, triggered by obesity.

The research by German scientists Michaela M. Mitschke, Ana Kilic, Linda S. Hoffmann et al. (2013) was conducted on mice, which were given Viagra. The animals, which were given Sildenafil (brand name of Viagra), turned out to be resistant to overweight and obesity despite being on a fatty diet.

There are millions of people all over the world, who are overweight. The problem is urgent, indeed. Many patients are looking for the solution. For those, who take sildenafil to boost sexual performance, the solution is unexpectedly close.

The abovementioned team from the German Federal Institute for Drugs & Medical Devices (BfArM), and the Max Planck Institute for Heart and Lung Research, headed by Prof. Pfeifer administrated the medicine to the mice for a week. They were amazed by the effect, since fat cells were converted into beige ones under the effect of Viagra. These “good” fat cells convert the energy (calories) from consumed food to heat. Beige fat just melts away undesirable pounds.

Beige fat is a type of adipose tissue featuring energy-burning properties. It can burn energy which comes from food consumption (breakfast, lunch, dinner, etc.). So scientists have hopeful expectations regarding its role on the body and an appropriate influence on it. Beige fat has some similarities with brown one, however, they have different cellular lineages.

Moreover, sildenafil prevents fat cells from accumulating lipids, which causes the release of hormones. They, in turn, lead to inflammation, which put a person at risk of experiencing cardio-vascular conditions (heart attack or stroke), cancer or diabetes. Sildenafil stops inflammatory processes. Consequently, Viagra, helping to stay slim, can serve a prophylaxis of a number of severe diseases. Scientists published their discovery in FASEB journal.

According to prof. Dr. Alexander Pfeifer such double influence of Viagra can be the real rescue for individuals, suffering from both erectile disorders and obesity.

The Medication’s Impact Isn’t Clear Yet

However, it’s still unclear whether it’s legit or not, since rodents are not humans. That is why, it cannot be still prescribed for the sake of getting rid of the couple of extra pounds. Naturally, there is no FDA approval for this. The proper dosage of Viagra for weight loss is not revealed yet. Possible side effects, in particular back pain, stomach ache, headache also have to be taken into consideration. Moreover, scientists are not sure about the probability of taking Viagra for the purpose of dealing with obesity by females. Further studies have to be conducted. Anyway, it would be great if the efficacy of Viagra in removing fat in humans were approved by specialized establishments.

Read our article: Viagra Abuse and Recreational Use: Risks & Dangers

Tips for Bodyweight Loss

Well, if you wanna get rid of fat, you need to maintain negative energy balance, that is, you should consume less energy than your body spends. If you still cannot lose fat, this means that you eat too much. Consult a nutritionist.

Keep in mind that food products have different caloric value. Fat is the most high-calorie nutrient, but in everyday diet carbs are usually key contributors for adding pounds.

Don’t forget about physical activity. It helps the body to spent excessive calories and maintain health of internal organs and systems.

Additional tips:

  • Drink enough water.
  • Eat more protein (poultry, legumes, etc.);
  • Eat at least 400 g of fruit and vegetables a day.
  • Sleep well.
  • Track and regularly measure your results.

Remember, that healthy weight prevents a bunch of diseases and helps to live happily.

viagra heart disease

Viagra-Like Drugs for Heart Attack: Could They Reverse Cardiovascular Events?

Viagra is a very popular drug with those who suffer from erection problems. Numerous research papers prove that Viagra is a powerful remedy for combatting erectile dysfunction. But the capabilities of the drug are not limited to this function. It can be also a great option for treating various diseases, in particular, heart failure, which is a very dangerous condition.

Viagra-Like Drugs and Heart Failure Treatment

Scientists have recently revealed that drugs, usually taken in case of problems with erection, are also effectual for treatment and prevention of heart failure. Among them is Viagra-like drug tadalafil. People, who face this heart disease, have a poor heart muscle, which fails to pump blood properly. Consequently, organs and tissues don’t get enough oxygen to maintain vital functions. According to The Centers for Disease Control and Prevention (CDC) approximately 6 million of American adults are diagnosed this condition. Half of them live fewer than 5 years after learning the doctor’s verdict.

viagra heart disease

Prof. Trafford together with his team conducted a study, aimed at revealing the properties of tadalafil. This drug belongs to the same category as Viagra (brand name of sildenafil) and is marketed as Cialis. The experiment was made on sheep, which were given tadalafil for removing symptoms of heart failure. Humans usually take tadalafil to escape from problems with erection. The 3 week research showed the significant improvement of the state of animals’ hearts. This drug contributed to the enhancement of the contraction of the heart as well as restoration of the organ’s reaction to the hormone, called epinephrine. Poor response to it leads to the heart failure. Professor claims, that the effect, experienced by the animals, will be the same in people. He adds that individuals, who take tadalafil for treating bad erection, unwittingly help their heart to opposite negative impact of ageing, bad habits and unfavorable conditions.

Another remedy, which is also probably good in dealing with heart conditions, is Viagra (sildenafil). It’s a revolutionary product, which helped millions of males to combat sexual dysfunction. Like tadalafil Viagra only theoretically can be beneficial for treating heart failure. As there is no clear scientific research in this respect further studies are required.

The main question is whether it’s safe to take Viagra if the patient has heart disease.

Some doctors insist that Viagra shouldn’t be taken by individuals with heart disease of certain type. It can cause dangerous outcomes.

You might be interested in: Diabetes and Heart Disease – Is There an Interconnection?

Side Effects of Viagra and ED Treatment

viagra heart side effects

There are certain side effects of sildenafil. Firstly, it can potentially minimize the pressure of the blood. Secondly, the interaction with nitrates is observed. Being a vasodilator, which dilates vessels, sildenafil puts down systolic pressure of the blood. Such vasodilating influence is hazardous in combination with the nitrates’ vasodilating effect. Nitrates are commonly prescribed to patients, who have problems with coronary artery. Those, who simultaneously take these two drugs, are at risk of getting strong hypotension and syncope. Therefore, sildenafil is prohibited to be taken together with nitrates (nitroglycerine such as Nitrolingual, Nitro-Dur patches, etc.).

On the other hand, sildenafil is tolerated quite well in males, suffering from coronary artery condition, if they don’t have severe ischemia and don’t take nitrates.

As sildenafil may contribute to the blood pressure drop, it may be dangerous for individuals with constant hypotension.

taking viagra cialis every day

Is it Ok to Take Viagra or Cialis Every Day?

Viagra and Cialis are usually administered on demand, that is, a person takes a pill when he plans to have sex in near time. Sometimes, people need to take these tabs every day. Is it ok? Are there any health risks?

Everyday Use of Viagra

Theoretically, one can use Viagra on an everyday basis. However, in practice such cases are not very frequent as not everyone (especially after 40, when prevalence of ED begins to rise) has sex every day. Moreover, some reported occasions of blindness which may be associated with prolonged administration of sildenafil may play a role of a preventive factor despite the fact that direct link between its use and hearing impairment hasn’t been established. Moreover, sildenafil is an active component of Revatio drug. Doctors prescribe it for treating pulmonary arterial hypertension, and patients need to take it every day. So we can conclude that “blue diamond” with the same sildenafil in composition is safe when taking on an ongoing basis.

FYI: professional article “Can You Take 2 Viagra Pills at Once? Is It Safe?”

At the same time, the medication doesn’t cause tolerance worsening. According to the study by James G McMurray et al. (Medical Affiliated Research Center, Pfizer Inc. etc., 2007), most of participants who had used the medication for a long time responded affirmatively when the surveyors asked them about successfulness of erectile dysfunction treatment. This means that durable administration of Viagra doesn’t cause loss of tolerability, it maintains the same effectiveness.

Conclusion: Viagra can be taken every day, that would be ok for your health. However, if you practice daily using (especially in high dosages), it is recommended to consult a healthcare professional.

Administration of Cialis on Daily Basis

Well, it depends. There are two recommended modes of taking Cialis. The first one is taking it on demand (as needed). Considering the fact, that tadalafil acts up to 1.5 days (36 hours), its administering on an everyday basis may be associated with increased risk of side effects as the substance just doesn’t have time to leave the body in full. Two pills are stacked, and the concentration of tadalafil in the blood remarkably increases, causing semi-overdose condition.

The second mode is daily treatment. A male can take low doses of Cialis (2.5 or 5 mg) every day, preferably at the same time, say 12 am. Such treatment can last long. It features the great advantage: there is no need for a patient to plan sex at all, he can have it anytime, as the active substance remains in the body on a permanent basis. This regime can bring more romanticism in a couple’s relationship.

You might be interested in: Is 20mg Cialis Equal to 100mg Viagra?

Interestingly, Cialis in minimal doses can treat benign prostate hyperplasia (prostate adenoma, BPH in short). Moreover, according to Konstantinos Hatzimouratidis (Hellenic Aristotle University of Thessaloniki, 2014), this is the only pharmaceutical product that can successfully treat both BPH and ED, because traditionally used medications for reducing urinary tract symptoms, including α-adrenergic antagonists and 5α-reductase inhibitors, are associated with sexual adverse events and may worse impotence.

Conclusion: Cialis in low dosages (2.5 mg or 5 mg) can be used daily, this has been officially allowed. If you take higher dosages (10 mg or 20 mg), time interval between doses should desirably be 36 hours.

Takeaways

Both Viagra and Cialis can be taken every day. But you can do that only if there is a real need. Plus, in case of Cialis you need to use the lowest dosage.

generic viagra manufacturers

Generic Viagra Manufacturers: Companies that Produce Sildenafil Drugs

Viagra is one of the most known pills in the world. However, its branded version, to put it bluntly, is not cheap. Fortunately, there is a widely accepted scheme according to which, when a patent for an original medication expires, other pharmaceutical companies (which are eligible to do this) acquire the right to manufacture an unpatented drug (generic). After appearance of generic products, original Viagra sales didn’t nosedive but remarkably decreased. Such a situation even forced Pfizer to announce the launch of its own generic product line. However, other drugmakers managed to earn fame, so now their drugs are very popular.

Well, do you want to know exactly which companies produce generics of Viagra? Then this article is for you.

Indian Drugmakers that Produce Sildenafil Generics

India is the biggest generic supplier in the world. Many companies producing generics of different kinds are based in Indian jurisdiction (examples are Cipla and Dr. Reddy’s). Such a position of India is associated with favorable conditions for pharmaceutical companies’ operating, relatively low salaries for workers, and some inapproachability with regard to patents’ action and lawsuits of genuine products’ manufacturers. Indian medicines are often sold over-the-counter.

Read our article: Over-the-Counter Viagra.

Ajanta Pharma

ajanta pharma kamagra

Ajanta Pharma is a specialized pharmaceutical company engaged in the development, production and marketing of high-quality medicines in both the Indian and international markets. This company was founded in 1973 with headquarters in Mumbai-India. Thus, this company has extensive experience (over 40 years) in manufacturing medicines. Ajanta consistently provides high quality affordable medicines for patients in different parts of the world. Recently, it has focused its production on exports and on the final Western consumer, in particular, tablets of this manufacturer are widely advertised in Europe (although they are not approved in all countries).

Ajanta Pharma is probably the most known producer of generic sildenafil, as this company produces Kamagra, Kamagra Jelly, and Kamagra Super. Let’s take a brief look at these preparations:

  • Kamagra is an ordinary sildenafil. Unlike genuine Viagra (the so-called “blue diamond”), this drug has turquois color. The most popular dosage is 100mg, but 50mg is also sold.
  • Kamagra Jelly. This is a unique remedy which is marketed in a gel form contained in sachets. It features various flavors such as banana, mint, strawberry, pineapple, orange, chocolate, cream, mango, rose and a few others.
  • Kamagra Super. This is a combination of sildenafil (an anti-ED agent) and dapoxetine, a substance which helps to handle premature ejaculation.

Sun Pharmaceutical Industries Ltd.

Sun Pharma was incorporated back in 1983. Initially it sold psychiatric products (five medications). In 1994 it launched IPO (Initial Public Offering). After parabolic growth, it expanded the network of drugs’ sale across more than 20 counties. Regarding innovative activity of the company it’s worth mentioning that it introduced gastroenterology products in India (in 1989).

This company produces, in particular, Caverta medication. It is interesting that earlier Caverta was produced by Sun Pharmaceutical Industries Ltd, but on 25th March 2015 Sun Pharma completed the acquisition of Ranbaxy Laboratories, so nowadays Ranbaxy actually doesn’t exist as a separate firm being an integral part of Sun.

In addition, according to the information on the company’s official website, it offers sildenafil in different dosages under the name RAN SILDENAFIL.

Centurion Laboratories

Centurion Laboratories is one of the largest generic manufacturing plants located in India. Centurion Laboratory produces more than 100 types of generics, from simple drugs, sedatives, drugs for the treatment of erectile dysfunction to serious anti-hepatitis, anti-tuberculosis, and anti-cancer drugs. Centurion Laboratories Pvt. was founded in 1998 in the city of Guyarat. In 2017, the company’s turnover amounted to more than $5 billion.

Centurion Labs produces several names of Viagra generics, in particular, Eregra and Cenforce. In addition to generic sildenafil, the company also manufactures generics of other PDE5 inhibitors, as well as drugs for the treatment of premature ejaculation, and natural remedies for the treatment of impotence.

Ranbaxy

Ranbaxy Laboratories Limited is the largest pharmaceutical corporation in India, a multinational manufacturer of a wide assortment of medicines.

Ranbaxy was established in 1961. In 2008, it entered into an alliance with one of the biggest Japanese innovative businesses, Daiichi Sankyo Company Ltd. As a result of this merger, the major player in the market of innovative and generic drugs emerged. The combined company today is among the 20 largest pharma behemoths in the world. In particular, it produces supplements (for example, iron-containing ones), antibacterial drugs, drugs for treating hypertension, medicines for men’s health, and many others.

The most known generic drug manufactured by Ranbaxy is Caverta.

Cipla

Cipla Limited is an Indian multinational pharmaceutical and biotechnology company, headquartered in Mumbai, India. Its production facilities are located in Belgium, Surrey in the EU, Miami, Florida in the United States, as well as in other countries. The company specializes in the production of drugs for respiratory, cardiovascular diseases, arthritis, diabetes, erectile dysfunction, and other conditions. It was founded by the Indian nationalist and scholar Khwaja Abdul Hamied back in 1935 in Mumbai. The products of this Indian corporation are approved by the American FDA.

Sipla produces a medication which is called Silagra. Another less-known generic is Assurans (in a tableted form).

Other Manufacturers

There are also other Indian companies less preeminent than the abovementioned ones. These are FDC (Zerect tabs), Medley (Vigreks tab), Bestochem (Rocky-50), Human Pharmacia (Sex-Gra), Dr. Reddy’s Lab (Rezum), Dynamic (Ratigra), Protec (Progra), Zydus Alidac (Penegra), Kopran (Nyte tab), Unichem (Erix), Torrent (Androz), IND-SWIFT (Adams Delite), and a bunch of others.

Canadian Companies Manufacturing Generic Viagra

Canada is considered a world leader by a quantity of online pharmacies which are based in this country. But in fact, in this country there are no many manufacturers producing Viagra generics comparing, for instance, with India.

Teva

Teva is one of the world’s leading manufacturers of generic drugs, which is among the 15 largest international pharmaceutical manufacturers. In addition to a wide selection of high-quality generics in such areas as cardiology, pulmonology, oncology, neurology and urology, the company also produces its own innovative medical products.

sildenafil teva

Teva is a company originating from Israel (its earliest predecessor was Jerusalem-based “Salomon, Levin, and Elstein Ltd.”). But it has multiple affiliated firms in different companies of the world, in particular, in Canada. Sildenafil Teva is a recognizable drug among many patients.

Pharmaris Canada

Pharmaris Canada is a young company, whose activity began in Peru in 2009 with subsequent expanding to other countries (Peru, Chile, Canada, and others). The Canadian branch is based in British Columbia.

Pharmaris Canada manufactures PRZ-Sildenafil medication.

It should also be noted that Mylan, a widely known pharma company, has launched sales of generic Viagra in 11 countries. But Canadian facilities of this corporation most probably don’t produce this medication, and it is not offered by Canada-based drugstores.

Mexican Drugmaking Companies

According to statistics, the United Mexican States is one of the largest markets for erectile dysfunction products (both pharmaceuticals and herbal products).

You might be interested in: Natural Alternatives to Viagra – Do They Really Work?

In addition, Mexico is famous for its producers of anabolic steroids, which are (although in Mexican pharmacies some anabolics may be bought without a prescription). Keep in mind that some of medications sold in this country may be counterfeited, this applies not only to anabolically active drugs but also to other kinds of meds, including Viagra.

mexican viagra

Besides semi-legal and underground manufacturers, Mexico is a base for many giant pharmaceutical corporations which have opened affiliate companies there. For instance, these are local branches of Schering Plough, Boehringer Ingelheim, Bayer, AztraZeneca, and GlaxoSmithKline.

In Mexico, there is also a branch of Pfizer company. It is interesting, that in 2011 Pfizer launched a special version of Viagra in Mexico. This was Viagra Jet (“Tabletas Masticables”), a chewable medication for males who didn’t like swallowing pills or capsules (but it is not known whether this version is sold nowadays). However, males may simply choose Kamagra Jelly.

Which Dosages Are Offered by Generic Viagra Manufacturers?

Of course, generic drugmakers offer classic dosages of Viagra, that is 25mg, 50mg, and 100mg. However, other variations are also possible. Sometimes you can find enhanced doses, like 150mg and 200mg. Some males can take advantages from increased quantity of sildenafil in the chosen product, but keep in mind that an increase in dosage does not necessarily mean improvement of the medication’s effectiveness.

Conclusions

There are a lot of generic Viagra producers on the market. But the key thing for a customer is not the choice of a manufacturer (as manufacturers don’t sell medications directly to users), his task should rather be finding a reliable supplier. Read more: Why is Canadian Health&Care Mall the Best Way to Order Generic Drugs?

viagra with water or milk

How to Take Viagra – With Water or Milk? What About Juices?

Very often, patients wash down drugs with whatever turns up, without thinking about it. It can be soda, juice, milk, tea, coffee and so on. But it can be unsafe for the human body. Below we will consider whether it is possible to take Viagra with milk and indicate the combinations that can never be done.

Is It Possible To Wash Down Medicines With Milk?

Sometimes doctors recommend taking some medications with milk in order to reduce the risk of damaging the mucous membrane of the gastrointestinal tract and soften the bitter taste of drugs. For instance, hydrocortisone is recommended to be taken with food or milk to prevent upset of the stomach.

Do not use milk to wash down medicinal products with acid-resistant coating, because the safety cover dissolves and the drug is destructed before reaching the point of absorption. For example, the combined use of the drug Dulcolax (a constipation drug) in the form of tablets with milk can lead to premature dissolution of the tablet shell and irritation of the stomach and duodenum.

Milk stops resorption of iron from iron-containing preparations (ferrous fumarate, ferrous gluconate, ferrous sulfate). It also impairs the absorption of tetracycline antibiotics.

Is It Possible To Wash Down Viagra With Milk?

Viagra has neither an acid-resistant coating nor iron elements. Therefore, theoretically, it can be taken with milk. But you, as a patient, should always know that you need to consistently and systematically observe official instructions.

Is Milk Good For Potency?

Milk contains such valuable components as vitamins (D, B, A, PP), macro- and microelements (zinc and iron, phosphorus and potassium, iodine and magnesium, potassium and sulfur, chlorine and selenium). Natural milk is rich in lactose, enzymes and lactic acids, globulins, casein and albumin. In general, milk is good for the body and can be good for potency. However, it cannot be used by people with lactose intolerance. There is also a point of view that milk is one of potential causes of acne and allergies in people prone to it. Some experts attribute this to the fact that milk supposedly contains elements of hormones intended for calves (if we are talking about cow’s milk) consequently, it is not suitable for the human body. But this is only a theory that still requires documentary evidence.

Viagra And Juices

viagra grapefruit juice

It is usually not recommended to take preparations with juices (unless otherwise indicated in the instruction, for example, creatine, which, however, is an additive and not a drug may be recommended to be washed down with grape juice). But the most important thing you need to know (must-know rule) is that you cannot combine Viagra with grapefruit or grapefruit juice. This fruit contains a substance that inhibits the activity of the enzyme responsible for the removal of drugs and toxins. Therefore, sildenafil can be released into the blood in unpredictable concentrations. Do you need it?

It may seem difficult to remember what you can, and what you cannot use to wash down this or that medicine. But in fact, there is nothing complex here. It is enough to read the instructions or ask the attending physician, and if it is not possible to do this, then wash down the medicine with water, you will not be mistaken for sure.

Final Recommendations

Always take Viagra with water as directed. This will ensure that the drug will work as it should. You should not experiment with different liquids for this purpose. Especially it concerns grapefruit juice (it is also not recommended to wash down the medicine with other citrus juices).

cialis or viagra

Is 20mg Cialis Equal to 100mg Viagra: Tadalafil / Sildenafil Doses Comparison

It is known that the maximum dosage of the original Viagra is 100 milligrams of sildenafil. The maximum dosage of branded Cialis is only 20 mg of tadalafil. However, can these dosages of two drugs be considered equal in terms of the strength of the effect?

Viagra vs Cialis: What’s the Difference?

We’ve thoroughly analyzed these drugs and decided to highlight key factors of differentiation.

  • Producer. Genuine Viagra is manufactured by Pfizer Inc., a renowned American pharmaceutical company. Original Cialis is produced by Eli Lilly, which is also a US-based pharma giant. However, this difference is not determinative in case of generics. They are produced by less-known Indian, Canadian, and European manufacturers. We would not advise to buy generic drugs from China, as a risk to get a counterfeit is elevated.
  • Dosage. Viagra comes in three main dosages: 25mg, 50mg, and 100mg. There are four versions of Cialis: 2.5mg, 5mg, 10mg, and 20mg. As you can see, even the minimal dosage of Viagra (25mg) has less pharmaceutical substance than the maximal-dosed Cialis version (20mg).
  • Appearance. Viagra is supplied as a diamond-shaped blue pill while Cialis is sold in the form of almond-shaped yellow-colored pills. In case of generics, the difference may be another (depending on the product you choose).
  • Uses. Viagra and Cialis are both used to treat erectile dysfunction. In addition, other drugs with their active agents are used to fight pulmonary arterial hypertension. These are Revatio (sildenafil) and Adcirca (tadalafil). What is more, there are perquisites to assume that Viagra may be also used for urinary symptoms of BPH, however, there is no official approval for such a purpose.
  • Time of Action. Viagra works for 4-6 hours, in some males the needed effect may be observed within a 12-hour period. Cialis acts much longer (see below).

There may also be other differences, but they are not significant.

cialis 20 mg vs viagra 100 mg

What is the Key Feature of Cialis?

The main advantage of Cialis is an increased biological half-life of the active substance, which is approximately from 17 to 20 hours. Due to this, the desired effect is guaranteed within 36 hours after consuming the pill. As we have noted above, the maximum possible period of action of Viagra is only 6 hours (rarely 12 hours). Interestingly, this advantage is achieved without the use of a higher dosage of tadalafil.

For one and a half days, Cialis (or tadalafil) suppresses the production of PDE5 enzyme in the body, causing the cessation of erection. This drug, as well as Viagra, is a selective PDE5 inhibitor. What does it mean? Cialis blocks PDE5 (phosphodiesterase type 5) enzyme more actively, virtually not affecting the rest of useful PDE enzymes. For example, PDE3 is involved in cardiac muscle contraction, vascular smooth muscle and platelet aggregation. The effect of Cialis on this enzyme is 10 thousand times weaker than on PDE5.

Cialis 20mg vs Viagra 100mg: What’s the Best Choice?

These drugs belong to the same family – PDE5 inhibitors. They also have about the same efficiency: they work in 80-90% of patients with the highest possible dosage.

However, Cialis is believed to have either a more concentrated or more potent substance, so it contains a lower dosage than its main competitor.

However, Cialis 20mg and Viagra 100mg are almost the same in terms of improving erections. Some may get the best effect from Cialis, while others may prefer Viagra. But do not think that Cialis in the 20-milligram dosage is weaker than Viagra and vice versa.

You might be interested in the following article: Can you improve your libido using Viagra?

Conclusion

Thus, in terms of dosage strength, these doses can theoretically be considered identical. But at the same time, they cannot be fully equated. Cialis has a different half-life, which makes its action time six times longer than that of Viagra (sildenafil lasts up to 6 hours, while tadalafil provides the desired effect up to 36 hours). So choosing one or another preparation is generally a matter of taste. Administering other medications may also influence the choice, since Cialis lasts longer in the body, consequently, the period of possible harmful interactions with other drugs becomes longer.

2 viagra pills at once

Can You Take 2 Viagra Pills at Once? Is It Safe?

Viagra medication is very popular among male persons suffering from an erection disorder. However, sometimes it does not work as it should, and sometimes patients want to get a “double” effect. They might ask whether it is possible to take two pills at once.

Some Important Facts About Viagra (Sildenafil)

The drug acts by improving blood flow in the genital area. Sildenafil (the basic component of Viagra) does not enhance sexual desire / libido and does not help improve feelings towards your partner. The blue pill isn’t an aphrodisiac. It only affects the physiological level, contributing to the filling of blood vessels in the vessels. Viagra will not work without excitement.

Some athletes use the drug to increase endurance in long-lasting or high-intensity workouts, to achieve new results in a gym. This practice is associated with the fact that sildenafil allegedly improves blood flow and muscle pumping. With careful use and proper dosage, some athletes do improve athletic performance. By the way, this category of people may be inclined to use higher dosages of the drug (taking two tablets or more per day). Partyers is another category which is prone to Viagra abusing.

Viagra Dosages on the Pharmaceutical Market

Traditionally, the drug is available in three dosages: 25mg, 50mg and 100mg. In some fellows, minimal dosages work, while other patients need an increased amount of the active ingredient of the product (sildenafil) to get the desired effect. The maximum daily dosage of Viagra is 100 mg; you should keep this in mind. However, some pharmacies offer elevated doses of the product, for example, 150mg and 200mg.

Increased Dosages of Viagra: Risks and Dangers

In this case, bigger dosages don’t mean better effect. “More” can actually mean “worse”, as has been shown by several clinic studies.

The fact is that super high doses of Viagra increase the risk of side effects, such as dizziness, back pain, facial flushing, dyspeptic disorders and the like. If a man gets these side effects, he is unlikely to want to have sex, or at least the pleasantness of intercourse will be overshadowed by a headache. Therefore, it is better not to expose your body to pharmaceutical dangers. Therefore, it is not advised to administer more than 100 milligrams of sildenafil per day.

Can You Take Two Viagra Pills at Once?

You already know the two most important facts:

  • there are three typical dosages of Viagra;
  • you cannot take more than 100 mg (0.1 g) per day.

From this we can conclude that taking two 100-milligram tablets is prohibited. However, theoretically you can take two pills of 25 mg or 50 mg at once. Keep in mind that for patients suffering from serious renal and hepatic diseases even a dosage of 100 mg may not be allowed.

Conclusion

Consuming two 100-milligram dosages at a time is definitely considered a potentially harmful practice. However, the use of two 25 or two 50 mg tablets at a time might be considered relatively safe, especially if you do not have other serious diseases (heart, kidney, liver, etc.).

viagra addiction

Can Viagra Cause Physiological or Psychological Addiction?

Viagra is a blockbuster drug that helps millions of men around the world fight a terrible intimate nuisance called erectile dysfunction. It also generates million dollar profits for pharmaceutical companies, and, we believe, it’s fair. For some men, this medicine has become a real lifesaver, which makes it possible to get the right effect at the right moment.

However, according to some people, Viagra can theoretically cause addiction, that is, a man loses the ability to get a normal erection after discontinuation of the drug in case of cure of the disease. Is it so? Can Viagra (sildenafil) cause physiological or psychological dependence?

Can Viagra Cause Physiological Addiction?

Definitely not, it just cannot do that. Let’s see why.

Physiological dependence is formed when the body gets used to the constant exogenous intake of substances involved in the metabolic processes and therefore reduces their endogenous production. For example, in the human body (in the process of metabolism) ethyl alcohol is produced in small quantities. With alcohol abuse, the body stops producing it and a person begins to feel bad. There are medicaments and substances that can cause physiological dependence. They belong to psychoactive substances that affect the functioning of the central nervous system, leading to a change in the mental state, sometimes up to an altered consciousness. They can be used for recreational purposes or in medicine.

These include neuroleptics (clozapine, haloperidol), depressants (barbiturates, chloroform), hallucinogens (dimenhydrinate – Draminate, Dramamine; scopolamine), stimulants (amphetamines, caffeine), and nicotine, which is contained in cigarettes. Viagra doesn’t belong to any of the above groups of substances.

Moreover, the instructions to the product do not indicate that it can cause psychotropic or other effects.

viagra addictive

Can Viagra Cause Psychological Dependence?

According to the official instructions, the medication cannot cause side effects of a psychological nature. Some patients may experience headaches, backache, facial flushing, gastrointestinal disorders, etc., but the drug itself does not affect the psyche. However, unfortunately, a patient can affect his state of mind. Even sunflower seeds may be addictive, you know…

There are several possible scenarios when Viagra can cause a psychological dependence, which is usually transient.

  1. The first scenario is when a man suffers from psychogenic erectile dysfunction, that is, he cannot achieve the desired hardness of the sexual organ due to fear, nervousness, anxiety, etc. Viagra can certainly help in such cases, as it activates the mechanisms of erection and improves a man’s confidence in himself. When a patient cancels a drug, he may lose some support at a psychological level. He begins to believe that he can get an erection only after taking Viagra and he cannot have sex without a “blue pill” because of psychological prejudices. It becomes a self-fulfilling prophecy because of the so-called performance anxiety.
  2. The second scenario is when a man suffers from organic erectile dysfunction and then cures the underlying cause of this condition, however, he gradually develops a psychological addiction to the drug. The mechanism of habit formation is the same as in the previous case.
  3. The third scenario is when a man begins to abuse the drug and, accordingly, demand more sex. According to doctors and psychologists, excessive use of the blue pill is a threat to the romantic relationship between partners and even to marriage. As a result, this form of drug dependence especially affects the emotional state of a patient.
  4. The fourth scenario is when a man is completely healthy and does not suffer from penile impotence, however, he begins to take Viagra (or another PDE5 inhibitor) for recreational purposes. After some time, he may notice that he is psychologically accustomed to this drug. This means that he cannot get a satisfactory erection without the help of sildenafil, the main active component of the “blue tablet”. He simply must take a pill, after which he gets the confidence that he will succeed. The number of fellas with psychological dependence on Viagra is gradually increasing, since it is widely used at parties, often in combination with narcotic drugs.

Finally, let allow us to set your mind at rest: such cases are relatively rare. If a man has a stable psyche and does not use other psychoactive compounds (narcotics) he most likely will not develop addiction to this excellent drug. The main thing is not to abuse the drug and have sex without it, if sexual health allows this. Viagra is not addictive like psychotropic preparations and cannot cause physiological addiction, but some patients may develop psychological dependency.

nytroglycerin viagra

Alternatives to Nitrates When Treating with Viagra and Cialis

Ischemic heart disease (IHD) is an acute or chronic myocardial damage resulting from a decrease or cessation of the supply of arterial blood to the heart muscle. Forms of IHD include angina pectoris (stable and unstable), myocardial infarction, heart failure, etc.

Unfortunately, coronary artery disease and erectile dysfunction (ED) in men often coexist. Inhibitors of phosphodiesterase type 5, such as Viagra and Cialis, have revolutionized the treatment of ED. However, they cannot be used together with nitrates, which are often prescribed to combat angina pain. Therefore, some patients have to look for substitutes.

Nitrate Drugs – What Are They?

Nitrates are drugs that are designed to eliminate the anginal pain that occurs with angina and myocardial infarction. According to practitioners, they occupy one of the leading places in cardiology practice.

Organic nitrates are divided into 2 groups by the duration of action:

  1. short-acting (stop attacks of anginal pain with angina or heart attack);
  2. long-acting (used for the prevention of angina attacks).

After entering the body from the nitrate molecule, the NO group is split off, which activates guanylate cyclase and thereby causes an increase in the level of cyclic guanosine monophosphate. The accumulation of this substance leads to the relaxation of smooth muscles of the walls of the coronary vessels, arteries and veins.

Nitrate class includes nitroglycerin, isosorbide dinitrate and isosorbide-5-mononitrate. They are available in various forms, including capsules, sublingual tablets, sprays, aerosols, mucoadhesive buccal patches, etc.

According to Drugs.com, their brand names include:

  • Minitran, Nitrek, Nitro-Bid, Nitro-Dur, Nitrolingual, NitroMist, NitroTab, Nitro-Time, Rectiv, Tridil (nitroglycerin);
  • Isordil Tembids, Isordil Titradose, Isosorbide Dinitrate CorePharma, Apo-ISDN, Isocord, Isocin (isosorbide dinitrate);
  • Imdur, Ismo, Isosorbide Mononitrate Actavis, Monoket, Apo-ISMN, PMS-Isosorbide, Monocord, Monocordil (isosorbide-mononitrate).

Options for Replacing Nitrates in the Treatment of ED

The use of nitrates in combination with PDE5 inhibitors is strictly contraindicated. This can lead to a rapid decrease in blood pressure (even fatal outcomes are known). Also, such a pernicious combination can lead to myocardial ischemia (due to a decrease in blood flow in stenotic coronary arteries).

So if you need to use Viagra or Cialis, you have two options. The first option is to ensure a sufficiently long gap between the use of nitrates and anti-ED drugs. Viagra is effective for 4-6 hours, but its particles may remain in the body longer. As Russian scientist V. Lupanov (2011) rightly points out, phosphodiesterase inhibitors used to treat erectile dysfunction from sildenafil, vardenafil, and tadalafil groups potentiate the hypotensive effect of nitrates, therefore, the use of nitrates should be avoided for 24-48 hours after using phosphodiesterase inhibitors. According to WebMD, in some cases, a man can stop taking nitrates to ensure the safe use of the drug to treat sexual impotence. However, patients who participated in the cited study took other heart remedies.

The second option involves the replacement of nitrate drugs used in antianginal therapy. As indicated in the study of American scientists Dioma U Udeoji and Ernst R Schwarz (Los Angeles, 2014), beta-blockers and calcium channel antagonists are usually considered the main means in antianginal therapy, but not all patients are well tolerated by these drugs. Moreover, some beta-blockers were associated with an increase in the incidence of male impotence. Scientists have tested the use of ranazoline (brand names Ranexa, Caroza, Cartinex, Rancad) as a replacement for nitrates. This medication causes a minimal reduction in blood pressure and a slight decrease in heart rate. All patients reported improved sexual function with ED drugs and control of symptoms of angina with ranazoline. Despite the fact that Ranexa may cause side effects (dizziness, headache, stomach problems), there are no contraindications for its joint administration with PDE5 inhibitors. However, this issue requires more detailed examination.

Other Considerations

If you are taking nitrates and decide to buy Viagra (Cialis), you should consult with your doctor about how to get out of this extraordinary situation. Viagra is not a vitamin supplement, and it is cannot be self-prescribed in case of heart diseases that lead to the consumption of nitrates, since this practice may be unsafe.

viagra abuse overdose

Viagra Abuse and Recreational Use: Risks & Dangers

Viagra is an anti-ED medication which should be used only if a patient suffers from erectile dysfunction. Its dosages should not exceed norms indicated in the instructions. However, these two simple rules are often violated by ED sufferers and even healthy males. Both Viagra abuse and recreational use may be associated with some health risks.

Viagra Abuse: Don’t Put Your Health in Peril

Back in 1998, after Viagra appeared on the market (making a revolutionary splash), a boatload of healthcare professionals were worried about the blatant cases of abuse of this “spellful” drug. Patients used it in quantities that were bigger than sanctioned ones. Situation has not changed since the date of the reports.

The key risk of using increased dosages of Viagra is overdose, and, subsequently, the possibility of more severe side effects occurrence. It’s known that the most frequent sides of the drug include:

  • headaches* (probably the most widespread unwished effect);
  • feeling dizzy;
  • blurred vision, cyanopsy (impaired color perception when a patient begins to see everything in blue);
  • hot face flashes;
  • nasal congestion;
  • nausea, dyspepsia, other gastrointestinal problems.

*Read more about headaches in a detailed article.

Contrary to popular belief, prolonged erection and priapism are not frequent occurrences when treating with Viagra. The medicine can also cause other unhealthinesses (like memory problems, ringing in the ears and hearing loss), however, they are typically rare.

However, in case of overdosage the abovementioned undesirable effects may be much severer. For instance, a man may experience loss of vision, a significant change in color perception, a sharp drop in blood pressure, a really bad headache, dangerous cardiovascular disorders, and priapism. There have been more sad occasions associated with the drug’s overdose, for example, amputation of the male organ, hospitalization with painful priapism, and even death due to the cardiac issues provoked by sildanafil and excessive sexual activity.

The most optimal dose of the medication is 50mg. Males with some pronounced health problems may take lowered dosage – 25mg, while patients with severe degree of ED or low responsiveness to sildenafil may switch to 100mg.

Many older drug users may unconsciously mix heart medications with impotence pills, which can lead to other health complications. When using very high dosages of the drug, the consequences can be unpredictable.

It is important: never combine sildenafil with nitrates (glyceryl trinitrate, isosorbide dinitrate, and isosorbide mononitrate.).

Some examples include: Minitran patch by Medicis Dermatologics, Nitrek by Bertek, Nitro-Bid by Savage, Isordil Tembids by Wyeth (in the United States); Apo-Nitroglycerin by Apotex, Nitro-Dur by Merck, Apo-ISDN by Apotex (in Canada).

What is Recreational Use of Drugs?

Recreational use (“recreation” means “rest”, “recuperation”) is the use of drugs that are not related to medical indications, for pleasure or other purposes. Opiates and cocaine, other psychostimulants, psychedelics and hallucinogens are most often used for recreational purposes. However, other drugs, especially Viagra, are no exception. Using recreational meds means that you are at risk. It can be unsafe and at some point, such usage can simply get out of control.

Viagra Recreational Use

What does Viagra do, according to the crowd’s opinion? Some people believe that it improves libido (sexual attraction), but this is not the case. This issue needs serious consideration, given the increasing wave of Viagra users. Viagra as a drug to improve penile erection is a very popular product, which occupies a permanent place in the lives of some party lovers.

Viagra may be combined with narcotics when used recreationally. Dennis G. Fisher, Robert Malow et al. (2006) detected consistent associations between the recreational use of sildenafil-based meds and amphetamines immediately before or during sexual intercourse. Moreover, according to the WebMD, abuse of the drug among males who have sexual contacts with other males may elevate the risk of sexually transmitted diseases and HIV. Of course, the Pfizer’s tablet itself doesn’t cause dangerous infections, however, researchers says that prolongation of penile erection time, better blood flow to the penis, and subsequent active sex may elevate the risk of catching these infections from a partner. Having pumped up with drugs and Viagra, a person gets wild sexual energy like a raging bull. He goes to bed to have filthy hot sex, discarding caution.

Moreover, males with recently diagnosed the human immunodeficiency virus more often use Viagra than non-infected fellows.

Conclusions

Be judicious and circumspect, when using Viagra to treat erectile dysfunction. Do not think that more is better. In fact, excessive doses mean more hazardous influence on the body. It is also not advised to use this pharmaceutical product for recreational purposes (“for fun”). Good health is the most precious of all possessions, so take care of it.