viagra and marijuana

Viagra and Marijuana: Dangers, Risks and Possible Benefits

A huge percentage of Viagra henchmen at the age of about 30-40 use it for entertainment purposes, for example, before visiting a club. They can combine it with alcoholic drinks and marijuana. A logical question appears: can you use ‘the blue pill’ and cannabis at the same time? Would this lead to increased risk of side effects?

Combining Marijuana and Viagra – Dangers and Risks

According to the official guidelines on Viagra use, there are no contraindications like ‘don’t combine Viagra with cannabis’. So it can be assumed, that moderate doses of marijuana may be combined with the sildenafil-based pill. However, we have found some important information to consider.

According to the study by Marie L. Eloi-Stiven (The Journal of Family Practice, 2007), illegal use of the weed is a strong predictor of recreational Viagra use. Smokers buy the erectile dysfunction pills from street vendors more often than non-smokers.

Besides health risks (associated, for example, with Viagra overdose), there is danger connected with the possibility of buying counterfeited tablets. They can contain harmful ingredients. Selling Viagra is a prerogative of pharmacies, individual street sellers (natural persons) cannot do that.

British clinicians A. L. McLeod and others (Clinical Cardiology, 2002) reported about severe case of myocardial infarction (MI) following the combined recreational use of sildenafil and cannabis. A 41-year-old male had no previous history of impotence, no increased blood pressure, and no family history of coronary arterial disease. Despite this he suffered from heart attack, which began to develop after smoking cannabis and consuming Viagra (recreationally).

As reported by Mayo Clinic experts, marijuana may inhibit an enzyme which is responsible for proper utilization of drugs in the body. Therefore, its consumption may lead to elevated concentrations of sildenafil in the blood, which is associated with increased incidence of adverse events, including severe ones.

Another disadvantage of using cannabis by ED suffers is that some studies suggest that it may contribute to the development of impotence.

cannabis and viagra

Are There Any Benefits?

Marijuana is licit in many countries. Therefore, every adult can try it. There is an opinion that cannabis is less harmful than alcohol. Ruben Baler, a scientist at National Institute on Drug Abus  says that it is possible to fatally overdose with alcoholic drinks, but an individual cannot do that with marijuana.

According to Charles W Webb and Sandra M Webb, medicinal use of marijuana has several health benefits. It helps to alleviate pain, treat insomnia and anxiety (Hawai’i Journal of Medicine & Public Health, 2014).

In addition, healthcare professionals from a research facility in Detroit have conducted a series of experiments on several hundred male volunteers who periodically smoke marijuana. As the results of the research have showed, about 70% of males who use weed in small quantities before intimacy experience more vivid feelings during sexual intercourse. Studying the sexual context, the scientists have revealed that cannabis influences nervous system, helping to cope with fear and nervousness. Along with these effects, the plant sharpens and heightens tactile sensations. In more than half of cases, male experienced a slight increase in sex desire, which positively influenced sexual intercourse.

However, due to the concerns described above, we wouldn’t recommend combining Viagra and cannabis. If you’ve decided to do that, take lower dose of sildenafil than usual. And keep in mind that serious side effects are possible anyway. So, this is at your peril.

viagra marijuana interactions

Moderation is the Key

As you’ve seen marijuana might be beneficial for the state of health. However, if you abuse this drug, this will do bad.

The same applies to Viagra. Don’t use this medicine ‘for fun’, if you actually don’t have erectile dysfunction. At the beginning of the article, we mentioned clubbers who can use the blue pill for such purposes. However, such misuse, especially in combination with narcotic substances may ruin the health and even lead to the deterioration of erection.

A related article: Viagra Abuse and Recreational Use: Risks & Dangers

is viagra a blood thinner

Is Viagra a Blood Thinner? Drug Interactions with Anticoagulants

Some males who take Viagra for treating erectile dysfunction also use anticoagulant medications, as the incidence of both cardiovascular diseases (events) and impotence rises with age. Can Viagra provide a blood-thinning action and are there any interactions with anticoagulants?

Can Viagra Cause a Blood-Thinning Effect?

Viagra is definitely neither a blood thinner, nor a blood pressure pill. It acts locally and specifically by inhibiting the activity of PDE5 enzyme, which is found primarily in the penile tissues and arteries of lungs (so it’s not dumbfounding that the active agent of the medicament is also used in a remedy which treats pulmonary arterial hypertension, it is called Revatio). When taken for ED treatment, Viagra allows for better blood flow in the penis.

viagra anticoagulant

After Viagra approval in 1998, there were several mysterious deaths of men who used the medication. Accidental death was not in the list of probable side effects of medication (and sildenafil proved to have a high safety profile). Despite that, some suspicions arose. In 2003, WebMD specialists wrote about unravelling of Viagra-associated mystery deaths. They cited Xiaoping Du and other researchers who discovered that the substance affected by Viagra (cGMP, via inhibition of PDE5) may be involved in blood clotting processes. These scientists believed that by boosting cGMP levels, the medicine might increase blood clot risks. However, after this research there was no adequate scientific confirmation of such side effect.

Viagra and Its Potential Interactions with Anticoagulant Medicines

Let’s start with the list of the most popular medicines which prevent formation of blood clots.

  1. Warfarin. This is the medication with old history of use. It was first used as a rat poison (for this purpose it was approved in 1948). However, clinicians quickly revealed anticoagulant action of warfarin in humans. In 1954, this pharmaceutical product was authorized for medical treatment of several diseases associated with blood clotting (deep vein thrombosis and pulmonary embolism). It also helps to prevent stroke in patients suffering from atrial fibrillation (AF) and heart valve disease, as well as in persons who has a device implanted into the heart as a replacement for dysfunctional native heart valve.
  2. Heparin. This remedy might seem to be an excellent choice for adherers of natural treatment, because naturally occurring glycosaminoglycan is the main active substance in it. Heparin was discovered back in 1916. Healthcare professionals commonly prescribe it to treat acute coronary syndrome, deep-vein thrombosis, atrial fibrillation and some other conditions. Heparin is also available as ointment which helps to treat phlebitis, thrombophlebitis, and hemorrhoid.
  3. Rivaroxaban. This oral anticoagulant (code name BAY 59-7939) is similar to warfarin. It has a lower risk of severe and potentially lethal bleeding in comparison with warfarin. However, it is associated with higher frequency of bleeding in the gastrointestinal tract.
  4. Dabigatran. The medication treats and prevents clotting, helps to prevent stroke in people having atrial fibrillation. Specifically, Dabigatran is a remedy of choice after knee or hip replacement surgery.

Other widely prescribed anticoagulants include apixaban, edoxaban, enoxaparin, and fondaparinux.

Warfarin appears to have no direct interactions with sildenafil. However, Medicinenet experts don’t recommend to combine erectile dysfunction medications with anticoagulants, such as warfarin and enoxaparin. Anyway, if you take any drug (especially a prescription one), consult a health care practitioner before start of Viagra administration.

Good to know: Is it Ok to Take Viagra or Cialis Every Day?

viagra interactions

The Bottom Line

Summing up, we can say Viagra has no anticoagulation effect, vice versa, it can potentially cause an opposite action. However, such a statement needs additional science-backed evidence with conducting large-scale studies. Most males take the “blue pill” without any side effects, some may experience mild ones like headache, muscle ache, and face reddening.

viagra and grapefruit

Viagra, Cialis, Levitra and Grapefruit Incompatibility: Mystery Revealed

You’ve probably heard that you should not combine grapefruit (grapefruit juices and smoothies) with ED tablets. But on the Internet, it’s hard to find an easy-to-understand and detailed article devoted to this issue. Our team have decided to fill the gap. No mysteries, just scientific facts.

Grapefruit and Medications

This fruit may alter pharmacokinetics of medicines by different ways. First, it causes irreversible inactivation of P450 (CYP) 3A4 enzyme in the intestine, which is responsible for oxidation of small foreign organic substances. As a result, metabolism is decreased and bioavailability of some orally taken pills increases. Secondly, it inhibits activity of P-glycoprotein which pumps a multitude of external substances out of cells. Due to complex mechanisms, this also elevated bioavailability of medicinal substances.

Healthcare professionals aren’t sure which chemicals in grapefruit are responsible for potentially dangerous interactions. Main candidates are furanocoumarins.

This doesn’t mean that grapefruits are harmful by themselves. They contain a lot of healthy substances, including vitamin C, Vitamin A, pantothenic acid, copper, dietary fiber, potassium, and others. However, if you take cardiovascular (and many other) types of medications, you should be careful.

A 2020 German Study

In 2001-2002 German researchers organized a study in Köln. There were 24 healthy and HIV negative participants involved with the average age 29 years. According to the experiment men were given one glass of fresh grapefruit juice, which they had to drink before the main meal. In 60 minutes, another one glass of the juice, accompanied with one more component – Viagra 50mg, was consumed. Over the next day scientists collected blood samples. The experiment was held again in a one week. Instead of grapefruit juice, males drunk ordinary water.

Results

It was revealed that Viagra’s absorption increased by 23 per cent when consumed with juice. With water the digestibility of the pharmaceutical is worse (which is considered normal). Grapefruit juice is also responsible for delaying of Viagra’s absorption. It’s important fact, since Viagra directly before sex may show no results if it is taken with this juice. Instead, it should be taken in advance.

The juice, involved in the research, was produced by Döhler company. Juices, supplied by other manufacturers, types, doses of them may show another effect. The scientists suggested that the combo of the “blue pill” and grapefruit juice is unwanted.

Patients, who take protease inhibitors (PIs), antiviral medications that are used to treat HIV/AIDS and hepatitis C, are recommended to take much lower dosage of Viagra, than the normal one. It’s because PIs are prone to raise Viagra’s level in many times. It’s dangerous for severe adverse events. That’s why, such individuals are also prohibited to combine grapefruit juice and Viagra.

cialis grapefruit

What About Cialis and Levitra?

These two medications may also be incompatible with grapefruit. There is a comprehensive study by D.G. Bailey and G.K. Dresser (London Health Sciences Centre, Ontario, 2004). The scientists investigated interactions between grapefruit juice and medications used to treat cardiovascular problems, including erectile dysfunction. They revealed that tadalafil and vardenafil (active components of Cialis and Levitra, respectively) may lead to severe systemic vasodilation, especially when ED pills are co-administered with nitrates. By the way, nitrate-based medicinal drugs are contraindicated if a patient takes ED pharmaceuticals.

A closely-related article: Alternatives to Nitrates When Treating with Viagra and Cialis

Conclusions

If you take an ED medication (PDE5 inhibitor group), stay away from grapefruit. Such a combination can make the action of a pill unpredictable and lead to undesirable consequences. When it comes to other dietary restrictions, it is recommended not to eat heavy meals while taking Viagra, Cialis or Levitra.

how to make viagra work faster

How to Make Viagra Work Faster? 5 Tips to Know

You probably know that when you treat any disease, it is not enough just to take a pill and wait for an effect. It is necessary to follow some rules of administration. Some medications should not be combined with alcohol, while some are recommended to be swallowed with milk.

Patients suffering from ED often want the needed effect from an ED pill as fast as possible. Unfortunately, Viagra doesn’t work immediately, but there are some tips that might help you to speed up onset of its action. We’ve prepared five useful recommendations for you.

Tip 1. Don’t Eat Too Fatty Foods

Donald J Nichols and others at Pfizer Central Research (Sandwich, 2002), reported about reduction in the speed of Viagra’s absorption and no alteration in extent of absorption when the medication was taken with high-fat meal, as compared to administering in the fasting state. What meals may be considered too fatty? These may be cheeseburgers, French fries, cheese fondue, salads with high amount of oils, fatty pork, fried chicken and some others.

Moreover, high-fat food may be harmful for health when consumed too often and/or in huge quantities. This may lead to cholesterol rate elevation, weight gain, and increased risk of cardiovascular diseases.

viagra fasted

Tip 2. Don’t Eat at All

If your stomach is full, this may slow absorption of sildenafil, the main component of Viagra. The most typical example to understand it better: if you eat well and drink alcohol, you get drunk slower.

So if you need the fastest effect, take Viagra on an empty stomach, for example, three hours after your last meal. In this case, you will most probably feel the effect 25-30 min after ingestion.

However, if you suffer from gastritis, dyspepsia or something like that, prolonged fasting may be inappropriate for you.

Tip 3. Avoid Alcohol

According to the study by Chinese scientists Lee AC, Ho LM et al. (The University of Hong Kong, 2010), alcohol consumption of 3 or more standard drinks per week might reduce satisfaction from sex and impair erectile function in males. In addition, high doses of alcoholic drinks taken before sexual intercourse may lead to delaying of arousal and worsening of erection. Scientists have also revealed that alcohol overconsumption negatively affects production of testosterone, a main male hormone responsible for healthy libido.

viagra and marijuana

Tip 3. Avoid Illicit Drugs, Marijuana, and… Grapefruit Juice

Illegal drugs and marijuana may worsen ED symptoms, thus leveling the effect of the blue pill. In addition, narcotics are harmful for general health (this cannot be said for sure with regard to marijuana, as you know, it can be used for recreational and medical purposes, but smoking hemp may not be a good idea if you are an erectile dysfunction sufferer and Viagra-taker).

Well, what about grapefruit? Point is that this fruit contains a chemical that interferes with the work of an enzyme which is responsible for removal of toxins and some medical substances from the body. As a result, the effect of Viagra and its onset of action may become unpredictable.

An important tip: Viagra should never be combined with nitrates. This may lead to severe blood pressure drop and even to lethal outcome. Nitrates are medicines used to treat angina. They include nitroglycerine, isosorbide dinitrate and some other meds.

So it may be better to use substitutes. Read our article: Alternatives to Nitrates When Treating with Viagra and Cialis. Don’t choose substitutes without consultation of a healthcare professional as their effects may vary.

Tip 4. Take It Slow

As mentioned earlier, ED medications don’t work right away. So you need to wait 30-60 min to achieve the desired effect. Viagra enhances the activity of a chemical nitric oxide (NO) which is due to the inhibition of PDE5 enzyme. This leads to muscle relaxation in the penile organ. Blood flow improves and you get better erection.

Note that the pharmaceutical doesn’t work without sexual stimulation. You need to be sexually aroused to get penis hardening. Of course, some time is needed to get yourself in the mood.

Remember, if you are worried that the medication is not working in time, there is no need of taking another tablet. Doubled dosage will not increase efficiency but may increase the risk of side effects, such as dizziness, face redness, headache, and arterial pressure plummeting.

viagra weight loss

Can Viagra (Sildenafil) Be Used As a Weight-Loss Drug: Research Data

Scientists have recently discovered one more property of Viagra, which is commonly used as a potency enhancer worldwide. The drug’s efficiency in treating erectile dysfunction (ED) and boosting sexual performance was approved by FDA in 1998. It stops the destruction of cGMP, which is a key regulator of blood flow in penis. Viagra contributes to proper blood supply to the men’s organ and provides excellent erection. That’s why it’s so popular with male patients who suffer from impotence.

Viagra’s Action Isn’t Limited: Fat-Melting Effect Explained

But now it’s also considered as an accelerator of the weight loss. The medication, despite its main function, converts excess fat cells, alerts resistance of insulin, and diminishes other complications, triggered by obesity.

The research by German scientists Michaela M. Mitschke, Ana Kilic, Linda S. Hoffmann et al. (2013) was conducted on mice, which were given Viagra. The animals, which were given Sildenafil (brand name of Viagra), turned out to be resistant to overweight and obesity despite being on a fatty diet.

There are millions of people all over the world, who are overweight. The problem is urgent, indeed. Many patients are looking for the solution. For those, who take sildenafil to boost sexual performance, the solution is unexpectedly close.

The abovementioned team from the German Federal Institute for Drugs & Medical Devices (BfArM), and the Max Planck Institute for Heart and Lung Research, headed by Prof. Pfeifer administrated the medicine to the mice for a week. They were amazed by the effect, since fat cells were converted into beige ones under the effect of Viagra. These “good” fat cells convert the energy (calories) from consumed food to heat. Beige fat just melts away undesirable pounds.

Beige fat is a type of adipose tissue featuring energy-burning properties. It can burn energy which comes from food consumption (breakfast, lunch, dinner, etc.). So scientists have hopeful expectations regarding its role on the body and an appropriate influence on it. Beige fat has some similarities with brown one, however, they have different cellular lineages.

Moreover, sildenafil prevents fat cells from accumulating lipids, which causes the release of hormones. They, in turn, lead to inflammation, which put a person at risk of experiencing cardio-vascular conditions (heart attack or stroke), cancer or diabetes. Sildenafil stops inflammatory processes. Consequently, Viagra, helping to stay slim, can serve a prophylaxis of a number of severe diseases. Scientists published their discovery in FASEB journal.

According to prof. Dr. Alexander Pfeifer such double influence of Viagra can be the real rescue for individuals, suffering from both erectile disorders and obesity.

The Medication’s Impact Isn’t Clear Yet

However, it’s still unclear whether it’s legit or not, since rodents are not humans. That is why, it cannot be still prescribed for the sake of getting rid of the couple of extra pounds. Naturally, there is no FDA approval for this. The proper dosage of Viagra for weight loss is not revealed yet. Possible side effects, in particular back pain, stomach ache, headache also have to be taken into consideration. Moreover, scientists are not sure about the probability of taking Viagra for the purpose of dealing with obesity by females. Further studies have to be conducted. Anyway, it would be great if the efficacy of Viagra in removing fat in humans were approved by specialized establishments.

Read our article: Viagra Abuse and Recreational Use: Risks & Dangers

Tips for Bodyweight Loss

Well, if you wanna get rid of fat, you need to maintain negative energy balance, that is, you should consume less energy than your body spends. If you still cannot lose fat, this means that you eat too much. Consult a nutritionist.

Keep in mind that food products have different caloric value. Fat is the most high-calorie nutrient, but in everyday diet carbs are usually key contributors for adding pounds.

Don’t forget about physical activity. It helps the body to spent excessive calories and maintain health of internal organs and systems.

Additional tips:

  • Drink enough water.
  • Eat more protein (poultry, legumes, etc.);
  • Eat at least 400 g of fruit and vegetables a day.
  • Sleep well.
  • Track and regularly measure your results.

Remember, that healthy weight prevents a bunch of diseases and helps to live happily.

viagra heart disease

Viagra-Like Drugs for Heart Attack: Could They Reverse Cardiovascular Events?

Viagra is a very popular drug with those who suffer from erection problems. Numerous research papers prove that Viagra is a powerful remedy for combatting erectile dysfunction. But the capabilities of the drug are not limited to this function. It can be also a great option for treating various diseases, in particular, heart failure, which is a very dangerous condition.

Viagra-Like Drugs and Heart Failure Treatment

Scientists have recently revealed that drugs, usually taken in case of problems with erection, are also effectual for treatment and prevention of heart failure. Among them is Viagra-like drug tadalafil. People, who face this heart disease, have a poor heart muscle, which fails to pump blood properly. Consequently, organs and tissues don’t get enough oxygen to maintain vital functions. According to The Centers for Disease Control and Prevention (CDC) approximately 6 million of American adults are diagnosed this condition. Half of them live fewer than 5 years after learning the doctor’s verdict.

viagra heart disease

Prof. Trafford together with his team conducted a study, aimed at revealing the properties of tadalafil. This drug belongs to the same category as Viagra (brand name of sildenafil) and is marketed as Cialis. The experiment was made on sheep, which were given tadalafil for removing symptoms of heart failure. Humans usually take tadalafil to escape from problems with erection. The 3 week research showed the significant improvement of the state of animals’ hearts. This drug contributed to the enhancement of the contraction of the heart as well as restoration of the organ’s reaction to the hormone, called epinephrine. Poor response to it leads to the heart failure. Professor claims, that the effect, experienced by the animals, will be the same in people. He adds that individuals, who take tadalafil for treating bad erection, unwittingly help their heart to opposite negative impact of ageing, bad habits and unfavorable conditions.

Another remedy, which is also probably good in dealing with heart conditions, is Viagra (sildenafil). It’s a revolutionary product, which helped millions of males to combat sexual dysfunction. Like tadalafil Viagra only theoretically can be beneficial for treating heart failure. As there is no clear scientific research in this respect further studies are required.

The main question is whether it’s safe to take Viagra if the patient has heart disease.

Some doctors insist that Viagra shouldn’t be taken by individuals with heart disease of certain type. It can cause dangerous outcomes.

You might be interested in: Diabetes and Heart Disease – Is There an Interconnection?

Side Effects of Viagra and ED Treatment

viagra heart side effects

There are certain side effects of sildenafil. Firstly, it can potentially minimize the pressure of the blood. Secondly, the interaction with nitrates is observed. Being a vasodilator, which dilates vessels, sildenafil puts down systolic pressure of the blood. Such vasodilating influence is hazardous in combination with the nitrates’ vasodilating effect. Nitrates are commonly prescribed to patients, who have problems with coronary artery. Those, who simultaneously take these two drugs, are at risk of getting strong hypotension and syncope. Therefore, sildenafil is prohibited to be taken together with nitrates (nitroglycerine such as Nitrolingual, Nitro-Dur patches, etc.).

On the other hand, sildenafil is tolerated quite well in males, suffering from coronary artery condition, if they don’t have severe ischemia and don’t take nitrates.

As sildenafil may contribute to the blood pressure drop, it may be dangerous for individuals with constant hypotension.

taking viagra cialis every day

Is it Ok to Take Viagra or Cialis Every Day?

Viagra and Cialis are usually administered on demand, that is, a person takes a pill when he plans to have sex in near time. Sometimes, people need to take these tabs every day. Is it ok? Are there any health risks?

Everyday Use of Viagra

Theoretically, one can use Viagra on an everyday basis. However, in practice such cases are not very frequent as not everyone (especially after 40, when prevalence of ED begins to rise) has sex every day. Moreover, some reported occasions of blindness which may be associated with prolonged administration of sildenafil may play a role of a preventive factor despite the fact that direct link between its use and hearing impairment hasn’t been established. Moreover, sildenafil is an active component of Revatio drug. Doctors prescribe it for treating pulmonary arterial hypertension, and patients need to take it every day. So we can conclude that “blue diamond” with the same sildenafil in composition is safe when taking on an ongoing basis.

FYI: professional article “Can You Take 2 Viagra Pills at Once? Is It Safe?”

At the same time, the medication doesn’t cause tolerance worsening. According to the study by James G McMurray et al. (Medical Affiliated Research Center, Pfizer Inc. etc., 2007), most of participants who had used the medication for a long time responded affirmatively when the surveyors asked them about successfulness of erectile dysfunction treatment. This means that durable administration of Viagra doesn’t cause loss of tolerability, it maintains the same effectiveness.

Conclusion: Viagra can be taken every day, that would be ok for your health. However, if you practice daily using (especially in high dosages), it is recommended to consult a healthcare professional.

Administration of Cialis on Daily Basis

Well, it depends. There are two recommended modes of taking Cialis. The first one is taking it on demand (as needed). Considering the fact, that tadalafil acts up to 1.5 days (36 hours), its administering on an everyday basis may be associated with increased risk of side effects as the substance just doesn’t have time to leave the body in full. Two pills are stacked, and the concentration of tadalafil in the blood remarkably increases, causing semi-overdose condition.

The second mode is daily treatment. A male can take low doses of Cialis (2.5 or 5 mg) every day, preferably at the same time, say 12 am. Such treatment can last long. It features the great advantage: there is no need for a patient to plan sex at all, he can have it anytime, as the active substance remains in the body on a permanent basis. This regime can bring more romanticism in a couple’s relationship.

You might be interested in: Is 20mg Cialis Equal to 100mg Viagra?

Interestingly, Cialis in minimal doses can treat benign prostate hyperplasia (prostate adenoma, BPH in short). Moreover, according to Konstantinos Hatzimouratidis (Hellenic Aristotle University of Thessaloniki, 2014), this is the only pharmaceutical product that can successfully treat both BPH and ED, because traditionally used medications for reducing urinary tract symptoms, including α-adrenergic antagonists and 5α-reductase inhibitors, are associated with sexual adverse events and may worse impotence.

Conclusion: Cialis in low dosages (2.5 mg or 5 mg) can be used daily, this has been officially allowed. If you take higher dosages (10 mg or 20 mg), time interval between doses should desirably be 36 hours.

Takeaways

Both Viagra and Cialis can be taken every day. But you can do that only if there is a real need. Plus, in case of Cialis you need to use the lowest dosage.

generic viagra manufacturers

Generic Viagra Manufacturers: Companies that Produce Sildenafil Drugs

Viagra is one of the most known pills in the world. However, its branded version, to put it bluntly, is not cheap. Fortunately, there is a widely accepted scheme according to which, when a patent for an original medication expires, other pharmaceutical companies (which are eligible to do this) acquire the right to manufacture an unpatented drug (generic). After appearance of generic products, original Viagra sales didn’t nosedive but remarkably decreased. Such a situation even forced Pfizer to announce the launch of its own generic product line. However, other drugmakers managed to earn fame, so now their drugs are very popular.

Well, do you want to know exactly which companies produce generics of Viagra? Then this article is for you.

Indian Drugmakers that Produce Sildenafil Generics

India is the biggest generic supplier in the world. Many companies producing generics of different kinds are based in Indian jurisdiction (examples are Cipla and Dr. Reddy’s). Such a position of India is associated with favorable conditions for pharmaceutical companies’ operating, relatively low salaries for workers, and some inapproachability with regard to patents’ action and lawsuits of genuine products’ manufacturers. Indian medicines are often sold over-the-counter.

Read our article: Over-the-Counter Viagra.

Ajanta Pharma

ajanta pharma kamagra

Ajanta Pharma is a specialized pharmaceutical company engaged in the development, production and marketing of high-quality medicines in both the Indian and international markets. This company was founded in 1973 with headquarters in Mumbai-India. Thus, this company has extensive experience (over 40 years) in manufacturing medicines. Ajanta consistently provides high quality affordable medicines for patients in different parts of the world. Recently, it has focused its production on exports and on the final Western consumer, in particular, tablets of this manufacturer are widely advertised in Europe (although they are not approved in all countries).

Ajanta Pharma is probably the most known producer of generic sildenafil, as this company produces Kamagra, Kamagra Jelly, and Kamagra Super. Let’s take a brief look at these preparations:

  • Kamagra is an ordinary sildenafil. Unlike genuine Viagra (the so-called “blue diamond”), this drug has turquois color. The most popular dosage is 100mg, but 50mg is also sold.
  • Kamagra Jelly. This is a unique remedy which is marketed in a gel form contained in sachets. It features various flavors such as banana, mint, strawberry, pineapple, orange, chocolate, cream, mango, rose and a few others.
  • Kamagra Super. This is a combination of sildenafil (an anti-ED agent) and dapoxetine, a substance which helps to handle premature ejaculation.

Sun Pharmaceutical Industries Ltd.

Sun Pharma was incorporated back in 1983. Initially it sold psychiatric products (five medications). In 1994 it launched IPO (Initial Public Offering). After parabolic growth, it expanded the network of drugs’ sale across more than 20 counties. Regarding innovative activity of the company it’s worth mentioning that it introduced gastroenterology products in India (in 1989).

This company produces, in particular, Caverta medication. It is interesting that earlier Caverta was produced by Sun Pharmaceutical Industries Ltd, but on 25th March 2015 Sun Pharma completed the acquisition of Ranbaxy Laboratories, so nowadays Ranbaxy actually doesn’t exist as a separate firm being an integral part of Sun.

In addition, according to the information on the company’s official website, it offers sildenafil in different dosages under the name RAN SILDENAFIL.

Centurion Laboratories

Centurion Laboratories is one of the largest generic manufacturing plants located in India. Centurion Laboratory produces more than 100 types of generics, from simple drugs, sedatives, drugs for the treatment of erectile dysfunction to serious anti-hepatitis, anti-tuberculosis, and anti-cancer drugs. Centurion Laboratories Pvt. was founded in 1998 in the city of Guyarat. In 2017, the company’s turnover amounted to more than $5 billion.

Centurion Labs produces several names of Viagra generics, in particular, Eregra and Cenforce. In addition to generic sildenafil, the company also manufactures generics of other PDE5 inhibitors, as well as drugs for the treatment of premature ejaculation, and natural remedies for the treatment of impotence.

Ranbaxy

Ranbaxy Laboratories Limited is the largest pharmaceutical corporation in India, a multinational manufacturer of a wide assortment of medicines.

Ranbaxy was established in 1961. In 2008, it entered into an alliance with one of the biggest Japanese innovative businesses, Daiichi Sankyo Company Ltd. As a result of this merger, the major player in the market of innovative and generic drugs emerged. The combined company today is among the 20 largest pharma behemoths in the world. In particular, it produces supplements (for example, iron-containing ones), antibacterial drugs, drugs for treating hypertension, medicines for men’s health, and many others.

The most known generic drug manufactured by Ranbaxy is Caverta.

Cipla

Cipla Limited is an Indian multinational pharmaceutical and biotechnology company, headquartered in Mumbai, India. Its production facilities are located in Belgium, Surrey in the EU, Miami, Florida in the United States, as well as in other countries. The company specializes in the production of drugs for respiratory, cardiovascular diseases, arthritis, diabetes, erectile dysfunction, and other conditions. It was founded by the Indian nationalist and scholar Khwaja Abdul Hamied back in 1935 in Mumbai. The products of this Indian corporation are approved by the American FDA.

Sipla produces a medication which is called Silagra. Another less-known generic is Assurans (in a tableted form).

Other Manufacturers

There are also other Indian companies less preeminent than the abovementioned ones. These are FDC (Zerect tabs), Medley (Vigreks tab), Bestochem (Rocky-50), Human Pharmacia (Sex-Gra), Dr. Reddy’s Lab (Rezum), Dynamic (Ratigra), Protec (Progra), Zydus Alidac (Penegra), Kopran (Nyte tab), Unichem (Erix), Torrent (Androz), IND-SWIFT (Adams Delite), and a bunch of others.

Canadian Companies Manufacturing Generic Viagra

Canada is considered a world leader by a quantity of online pharmacies which are based in this country. But in fact, in this country there are no many manufacturers producing Viagra generics comparing, for instance, with India.

Teva

Teva is one of the world’s leading manufacturers of generic drugs, which is among the 15 largest international pharmaceutical manufacturers. In addition to a wide selection of high-quality generics in such areas as cardiology, pulmonology, oncology, neurology and urology, the company also produces its own innovative medical products.

sildenafil teva

Teva is a company originating from Israel (its earliest predecessor was Jerusalem-based “Salomon, Levin, and Elstein Ltd.”). But it has multiple affiliated firms in different companies of the world, in particular, in Canada. Sildenafil Teva is a recognizable drug among many patients.

Pharmaris Canada

Pharmaris Canada is a young company, whose activity began in Peru in 2009 with subsequent expanding to other countries (Peru, Chile, Canada, and others). The Canadian branch is based in British Columbia.

Pharmaris Canada manufactures PRZ-Sildenafil medication.

It should also be noted that Mylan, a widely known pharma company, has launched sales of generic Viagra in 11 countries. But Canadian facilities of this corporation most probably don’t produce this medication, and it is not offered by Canada-based drugstores.

Mexican Drugmaking Companies

According to statistics, the United Mexican States is one of the largest markets for erectile dysfunction products (both pharmaceuticals and herbal products).

You might be interested in: Natural Alternatives to Viagra – Do They Really Work?

In addition, Mexico is famous for its producers of anabolic steroids, which are (although in Mexican pharmacies some anabolics may be bought without a prescription). Keep in mind that some of medications sold in this country may be counterfeited, this applies not only to anabolically active drugs but also to other kinds of meds, including Viagra.

mexican viagra

Besides semi-legal and underground manufacturers, Mexico is a base for many giant pharmaceutical corporations which have opened affiliate companies there. For instance, these are local branches of Schering Plough, Boehringer Ingelheim, Bayer, AztraZeneca, and GlaxoSmithKline.

In Mexico, there is also a branch of Pfizer company. It is interesting, that in 2011 Pfizer launched a special version of Viagra in Mexico. This was Viagra Jet (“Tabletas Masticables”), a chewable medication for males who didn’t like swallowing pills or capsules (but it is not known whether this version is sold nowadays). However, males may simply choose Kamagra Jelly.

Which Dosages Are Offered by Generic Viagra Manufacturers?

Of course, generic drugmakers offer classic dosages of Viagra, that is 25mg, 50mg, and 100mg. However, other variations are also possible. Sometimes you can find enhanced doses, like 150mg and 200mg. Some males can take advantages from increased quantity of sildenafil in the chosen product, but keep in mind that an increase in dosage does not necessarily mean improvement of the medication’s effectiveness.

Conclusions

There are a lot of generic Viagra producers on the market. But the key thing for a customer is not the choice of a manufacturer (as manufacturers don’t sell medications directly to users), his task should rather be finding a reliable supplier. Read more: Why is Canadian Health&Care Mall the Best Way to Order Generic Drugs?

viagra with water or milk

How to Take Viagra – With Water or Milk? What About Juices?

Very often, patients wash down drugs with whatever turns up, without thinking about it. It can be soda, juice, milk, tea, coffee and so on. But it can be unsafe for the human body. Below we will consider whether it is possible to take Viagra with milk and indicate the combinations that can never be done.

Is It Possible To Wash Down Medicines With Milk?

Sometimes doctors recommend taking some medications with milk in order to reduce the risk of damaging the mucous membrane of the gastrointestinal tract and soften the bitter taste of drugs. For instance, hydrocortisone is recommended to be taken with food or milk to prevent upset of the stomach.

Do not use milk to wash down medicinal products with acid-resistant coating, because the safety cover dissolves and the drug is destructed before reaching the point of absorption. For example, the combined use of the drug Dulcolax (a constipation drug) in the form of tablets with milk can lead to premature dissolution of the tablet shell and irritation of the stomach and duodenum.

Milk stops resorption of iron from iron-containing preparations (ferrous fumarate, ferrous gluconate, ferrous sulfate). It also impairs the absorption of tetracycline antibiotics.

Is It Possible To Wash Down Viagra With Milk?

Viagra has neither an acid-resistant coating nor iron elements. Therefore, theoretically, it can be taken with milk. But you, as a patient, should always know that you need to consistently and systematically observe official instructions.

Is Milk Good For Potency?

Milk contains such valuable components as vitamins (D, B, A, PP), macro- and microelements (zinc and iron, phosphorus and potassium, iodine and magnesium, potassium and sulfur, chlorine and selenium). Natural milk is rich in lactose, enzymes and lactic acids, globulins, casein and albumin. In general, milk is good for the body and can be good for potency. However, it cannot be used by people with lactose intolerance. There is also a point of view that milk is one of potential causes of acne and allergies in people prone to it. Some experts attribute this to the fact that milk supposedly contains elements of hormones intended for calves (if we are talking about cow’s milk) consequently, it is not suitable for the human body. But this is only a theory that still requires documentary evidence.

Viagra And Juices

viagra grapefruit juice

It is usually not recommended to take preparations with juices (unless otherwise indicated in the instruction, for example, creatine, which, however, is an additive and not a drug may be recommended to be washed down with grape juice). But the most important thing you need to know (must-know rule) is that you cannot combine Viagra with grapefruit or grapefruit juice. This fruit contains a substance that inhibits the activity of the enzyme responsible for the removal of drugs and toxins. Therefore, sildenafil can be released into the blood in unpredictable concentrations. Do you need it?

It may seem difficult to remember what you can, and what you cannot use to wash down this or that medicine. But in fact, there is nothing complex here. It is enough to read the instructions or ask the attending physician, and if it is not possible to do this, then wash down the medicine with water, you will not be mistaken for sure.

Final Recommendations

Always take Viagra with water as directed. This will ensure that the drug will work as it should. You should not experiment with different liquids for this purpose. Especially it concerns grapefruit juice (it is also not recommended to wash down the medicine with other citrus juices).

cialis or viagra

Is 20mg Cialis Equal to 100mg Viagra: Tadalafil / Sildenafil Doses Comparison

It is known that the maximum dosage of the original Viagra is 100 milligrams of sildenafil. The maximum dosage of branded Cialis is only 20 mg of tadalafil. However, can these dosages of two drugs be considered equal in terms of the strength of the effect?

Viagra vs Cialis: What’s the Difference?

We’ve thoroughly analyzed these drugs and decided to highlight key factors of differentiation.

  • Producer. Genuine Viagra is manufactured by Pfizer Inc., a renowned American pharmaceutical company. Original Cialis is produced by Eli Lilly, which is also a US-based pharma giant. However, this difference is not determinative in case of generics. They are produced by less-known Indian, Canadian, and European manufacturers. We would not advise to buy generic drugs from China, as a risk to get a counterfeit is elevated.
  • Dosage. Viagra comes in three main dosages: 25mg, 50mg, and 100mg. There are four versions of Cialis: 2.5mg, 5mg, 10mg, and 20mg. As you can see, even the minimal dosage of Viagra (25mg) has less pharmaceutical substance than the maximal-dosed Cialis version (20mg).
  • Appearance. Viagra is supplied as a diamond-shaped blue pill while Cialis is sold in the form of almond-shaped yellow-colored pills. In case of generics, the difference may be another (depending on the product you choose).
  • Uses. Viagra and Cialis are both used to treat erectile dysfunction. In addition, other drugs with their active agents are used to fight pulmonary arterial hypertension. These are Revatio (sildenafil) and Adcirca (tadalafil). What is more, there are perquisites to assume that Viagra may be also used for urinary symptoms of BPH, however, there is no official approval for such a purpose.
  • Time of Action. Viagra works for 4-6 hours, in some males the needed effect may be observed within a 12-hour period. Cialis acts much longer (see below).

There may also be other differences, but they are not significant.

cialis 20 mg vs viagra 100 mg

What is the Key Feature of Cialis?

The main advantage of Cialis is an increased biological half-life of the active substance, which is approximately from 17 to 20 hours. Due to this, the desired effect is guaranteed within 36 hours after consuming the pill. As we have noted above, the maximum possible period of action of Viagra is only 6 hours (rarely 12 hours). Interestingly, this advantage is achieved without the use of a higher dosage of tadalafil.

For one and a half days, Cialis (or tadalafil) suppresses the production of PDE5 enzyme in the body, causing the cessation of erection. This drug, as well as Viagra, is a selective PDE5 inhibitor. What does it mean? Cialis blocks PDE5 (phosphodiesterase type 5) enzyme more actively, virtually not affecting the rest of useful PDE enzymes. For example, PDE3 is involved in cardiac muscle contraction, vascular smooth muscle and platelet aggregation. The effect of Cialis on this enzyme is 10 thousand times weaker than on PDE5.

Cialis 20mg vs Viagra 100mg: What’s the Best Choice?

These drugs belong to the same family – PDE5 inhibitors. They also have about the same efficiency: they work in 80-90% of patients with the highest possible dosage.

However, Cialis is believed to have either a more concentrated or more potent substance, so it contains a lower dosage than its main competitor.

However, Cialis 20mg and Viagra 100mg are almost the same in terms of improving erections. Some may get the best effect from Cialis, while others may prefer Viagra. But do not think that Cialis in the 20-milligram dosage is weaker than Viagra and vice versa.

You might be interested in the following article: Can you improve your libido using Viagra?

Conclusion

Thus, in terms of dosage strength, these doses can theoretically be considered identical. But at the same time, they cannot be fully equated. Cialis has a different half-life, which makes its action time six times longer than that of Viagra (sildenafil lasts up to 6 hours, while tadalafil provides the desired effect up to 36 hours). So choosing one or another preparation is generally a matter of taste. Administering other medications may also influence the choice, since Cialis lasts longer in the body, consequently, the period of possible harmful interactions with other drugs becomes longer.