Active Ingredient

Metoclopramide

Metoclopramide is a medication used to treat certain conditions of the stomach and intestines. It helps in managing symptoms like nausea, vomiting, and digestive discomfort.

This medication is often prescribed for short-term use, especially when other treatments have not been effective.

Written By Douglas C. Goldberg, MD

Reviewed By Philip Schein, MD

Last Updated 28 Nov 2025

Available Metoclopramide Brands

Metoclopramide

Strengths 10mg

Reglan

Strengths 10mg

Metoclopramide Uses

Metoclopramide is commonly used for various digestive issues and related symptoms.

Treatment of nausea and vomiting
Management of gastroesophageal reflux disease (GERD)
Relief of symptoms in delayed gastric emptying
Control of nausea in patients undergoing chemotherapy

How Metoclopramide Works

Metoclopramide works by increasing the movements or contractions of the stomach and intestines. This helps speed up the passage of food through the stomach.

It acts on the brain to block signals that trigger nausea and vomiting, providing relief from these symptoms.

Common side effects of Metoclopramide

Not everyone experiences side effects from Metoclopramide, and many side effects are mild and temporary.

Drowsiness
Fatigue
Restlessness
Headache
Dizziness
Diarrhea

If you experience serious or persistent side effects, contact your doctor promptly.

Avoid alcohol while taking Metoclopramide as it can increase drowsiness.
Monitor for any unusual movements or muscle stiffness and report them to your doctor.
Inform your healthcare provider about any other medications you are taking to avoid interactions.
Do not drive or operate heavy machinery if you feel drowsy after taking this medication.
Notify your doctor if you have a history of depression or other mental health conditions.

Always consult your doctor for personalized medical advice.

Frequently Asked Questions

What does Metoclopramide do?

Metoclopramide helps in relieving symptoms of nausea, vomiting, and digestive discomfort by enhancing stomach movement.

How quickly does Metoclopramide work?

The effects of Metoclopramide can usually be felt within 30 to 60 minutes after taking it.

How long does Metoclopramide stay in your system?

Metoclopramide generally stays in the system for about 6 to 8 hours, but this can vary based on individual factors.

Is Metoclopramide safe for long-term use?

Metoclopramide is typically prescribed for short-term use due to potential side effects with prolonged use. Consult your doctor for advice specific to your condition.

Can Metoclopramide interact with other medications?

Yes, Metoclopramide can interact with other medications. It’s important to inform your doctor about all the medicines you are taking.