Metoclopramide

Common use

Metoclopramide is a medication primarily used to treat nausea, vomiting, and delayed gastric emptying (gastroparesis), especially in diabetic patients. It works by enhancing muscle contractions in the upper digestive tract, allowing food to move more easily through the stomach. It is also used to relieve symptoms of gastroesophageal reflux disease (GERD) when other medications are not effective. In some cases, it is given before chemotherapy or surgery to prevent nausea.

Dosage and direction

The typical adult dose for gastroparesis or GERD is 10 mg taken 30 minutes before meals and at bedtime, usually for 2–8 weeks. For chemotherapy-induced nausea, it may be given intravenously in higher doses under medical supervision. The medication should be taken exactly as prescribed and not for longer than 12 weeks due to risk of serious side effects. Always follow your healthcare provider’s directions carefully.

Precautions

Contraindications

Possible side effect

Common side effects include fatigue, restlessness, and diarrhea. More serious adverse effects may include involuntary muscle movements (tardive dyskinesia), especially with long-term use. Some individuals may also experience depression or anxiety. Seek immediate medical attention for symptoms like muscle stiffness, high fever, or confusion.

Drug interaction

Metoclopramide can interact with medications that affect dopamine levels, such as antipsychotics or Parkinson’s drugs. It may also enhance the effects of sedatives, alcohol, and certain antidepressants. Inform your doctor of all medications and supplements you are taking. Combining it with drugs that prolong QT interval may increase the risk of serious heart rhythm problems.

Missed dose

Overdose

Storage

Disclaimer

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