Generic Aralen

While scientists are working on developing new methods of COVID treatment, people use readily available medications which has proven effectiveness against coronavirus. These meds include HIV antivirals like an old drug chloroquine (CQ) phosphate.

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This medication has long been used for the treatment of malaria, amebiasis, and some autoimmune diseases.

However, malaria pathogens have developed some level of resistance to CQ, so with appearance of new medications to treat this disease, people have started to use it for prevention purposes.

In the past decade, due to non-frequent usage and relatively low demand, its production was remarkably reduced, but many online pharmacies including this one still offer chloroquine under different trade names.

Aralen is a Sanofi Avensis brand name, and there are generic versions of it, such as Dawaquin and Lariago.

When it comes to malaria, it is clearly known that the drug affects acid vesicles of parasites like Plasmodium malariae. This medication inhibits DNA synthesis and causes the death of asexual erythrocytic forms of all types of plasmodium, as well as dysenteric amoeba.

The active component of the tablet binds free radicals, stabilizes cell and subcellular membranes, and also has a number of other beneficial effects.

It has been shown that CQ can significantly inhibit CoV-2 infection in vitro. This beneficial effect is greatly supplemented with anti-inflammatory properties of chloroquine.

It is known, that old SARS virus which caused an epidemic in 2000s is a ‘relative’ of the novel COVID. In 2004, researchers at University of Leuven (Belgium) published a study, according to which chloroquine may be considered for immediate taking in the prevention and therapy of SARS-CoV infections.

In 2020, there were reports that antimalarial medications, including this one, may be effective against coronavirus due to their powerful antiviral effect. In particular, it was named an appropriate choice for large-scale use due to proven safety, high availability, and relatively low price. Currently there are about 10 trials which should shed more light on the peculiarities of CQ use in the treatment of COVID-2019.

According to newly issued guidelines (by Chinese scientists from multicenter collaboration group of Department of Science and Technology of Guangdong Province), the medicine might lead to improvement of success rates (and thereby reduce fatality), shorten the time of staying in hospital, and improve outcomes related to the dangerous disease. These researchers also provided the public with a consensus regarding proper use of chloroquine.

So, patients need to take 500 mg twice per day. How long should you use it? 10-day treatment is considered an optimal duration. Chloroquine is suitable regardless of the course of disease (mild, moderate, or severe).

Make sure that you don’t have contraindications to the administration of the drug.

Don’t use the medication if you have:

• retinal or visual field disorders of any etiology
• known hypersensitivity to components of the drug or to 4-aminoquinoline compounds

As you see, this list is not huge, but caution is also needed if you suffer from cardiac diseases. In addition, tell your healthcare professional in case of pregnancy or breastfeeding.

In some cases, CQ may cause the following adverse events:

• severe hypoglycemia (drop in blood sugar levels in the body),
• maculopathy (pathological disorder of the macula, an area at the center of the retina) and macular degeneration,
• retinopathy,
• urticarial, other immune system disorders,
• anemia, thrombocytopenia, and other blood disorders,
• gastrointestinal disorders, such as diarrhea and cramps,
• transient headache, extrapyramidal disorders like dystonia and dyskinesia,
• anxiety, insomnia, and other neuropsychiatric conditions,
• cardiac arrhythmias

The list is not exhaustive, contact your doctor if you experience any persisting and / or severe adverse reaction.

Don’t exceed recommended dosages, this exacerbates the risk of side effects.

Antacids disrupt the absorption of this medication, while cimetidine increases the concentration of chloroquine in the blood plasma. Better avoid combination with these groups of medications.