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How Long Does Tadalafil Stay in Your System?

May 30, 2020/in Canada Drugs /by Md. Philip Schein

Many medications belonging to the group of PDE5 inhibitors have relatively short-acting effect. They usually work for up to 6 hours. In predominant part of situations, this would be enough, but sometimes males can complain of poor spontaneity. Luckily enough, there is a great option of them which is called Cialis. Its branded version is pretty expensive, but there are many licensed and certified generics featuring tadalafil (the key component of Cialis) on the pharmaceutical market. So tadalafil stays in the system much longer, providing long-running effect. How long does it stay in the human body?

Tadalafil – Mechanism of Action

Erectile dysfunction is an annoying problem. Struggling with poor erections can induce nervousness, decreased confidence and relationship worsening. But oral treatment with tadalafil provides perfect results. The principle of action is basically the same as that of the preeminent azure pill (we mean Viagra), but this medicine contains another active component. This is a PDE5 inhibitor which suppresses natural substance which interferes with erection (phosphodiesterase type 5), thereby tadalafil boosts blood flow and increases penile hardness. Its manufacturers have succeeded in creation of more potent substance that can provide the same effect as Viagra with lowered dosage of the principal constituent.

how long does cialis generic stay in the body

Tadalafil – Time of Staying in the Organism

Most of phosphodiesterase type 5 inhibitors stay in the human organism for up to 6 hours. This concerns Viagra, for example (however, some studies have been shown that it might be effective for up to 12 hours in many patients). Anyway, its effect begins to abruptly or gradually decrease once 5-6 hours have passed. Tadalafil is definitely a winner in this regard, it provides useful effect for up to 36 hours (up to 1.5 days!). Such a long action is associated with its half-life. According to a study by Robert M Coward and Culley C Carson (Therapeutics and Clinical Risk Management, 2008), the half-life of this pharmaceutical substance is 17.5 hours in normal healthy males and 21.6 hours in the elderly.

Note that tadalafil is a symptomatic and temporary treatment, not a cure, for erectile dysfunction. Many gentlemen use it for an extended period (it doesn’t cause tolerability and addiction, which is a pretty good side of it). Durable therapy doesn’t lead to a loss of tolerance; you may not worry about it. Numerous clinical studies have shown that long-term treatment is unproblematic if the instructions for administration are carefully followed.

You might be interested in: Is 20 mg Cialis Equal to 100 mg Viagra?

Precautions

Averagely 5-10 per cent of users experience undesirable reactions like headache, backache, stomach upset, memory issues (forgetfulness), and flu-like symptoms. If used improperly (in excessive dosages), adverse events’ risk increases.

According to a study performed by clinicians at University of Köln, Germany in 2002, pharmacokinetics (drug absorption and delivery in the body) of PDE5 inhibitors (like sildenafil and tadalafil) may become less predictable when a patient takes grapefruit juice. This associated with the fact that substances in grapefruit oppress activity of cytochrome P450 3A4 (abbreviated CYP3A4) enzyme which located primarily in intestine liver and is responsible for removal of toxins and some pharmaceutical agents from the organism. Hence, don’t eat grapefruit and don’t drink grapefruit-based juices and smoothies when using tadalafil. This especially applies to Cialis as it has long half-life.

Levitra Interactions With Alcohol, Drugs, and Food

April 24, 2020/in Canada Drugs /by Md. Philip Schein

If you are taking any medication, you should know that it is potentially capable of interacting with other substances that may be found in food, medicine, alcohol, etc. We decided to prepare important material regarding the safety of combining levitra with various products.

Levitra and Food

If you use Viagra, it is not recommended to take the drug with alcohol and after having a heavy meal, it is known that very fatty food prolongs the onset of the desired effect, and the ethyl alcohol contained in alcoholic beverages increases the risk of side effects. However, in the case of Levitra, reportedly, no serious troubles should be associated with food.

Despite this, there are general warnings regarding the combination of many medicines with grapefruit.

So, it is not recommended to drink fresh grapefruit juice, as this can change the rate of Levitra absorption. This also applies to the consumption of fruit and smoothies. There are no clear data regarding processed products such canned juice and jam, but it is better to play it safe and also avoid them. Grapefruit contains substances called furanocoumarins, acting on the metabolizing enzyme cytochrome P450 3A4 (CYP3A4). This enzyme is localized mainly in the intestines and liver and it is responsible for removing various toxic substances and active ingredients of the drug from the body. If this enzyme is not affected, a normal (prescribed by the manufacturer) amount of the active ingredient enters the body. But if it is weakened, the blood receives a large concentration of a substance, in this case vardenafil. This can lead to an unpredictable, potentially dangerous increase of vardenafil in blood.

Levitra and Alcohol – Detailed Explanations

Alcoholic drinks are allowed, but avoid their excessive consumption. Depending on your weight and susceptibility to alcohol, you can drink 2-4 glasses of beer, a similar amount of wine, or a couple of glasses of a stronger drink. If you overdo it, you will get an increased likelihood of developing negative effects.

You might be interested in: How Long Does Levitra Last?

The Role of Alcohol in Erectile Dysfunction

Regardless of whether you take the pill for ED, chronic or rare but excessive consumption of alcoholic beverages can negatively affect the state of your sexual function. Alcohol abuse, according to statistics, is one of the key reasons for the development of erectile dysfunction. Therefore, by using increased amounts of alcohol, you can actually level the effect of Levitra and muddle the money spent on treatment. Be prudent and try to understand that health is more important than alcohol-powered party.

Medications

Levitra might interact with some medicines, including alpha-blockers, antihypertensives, and potent CYP3A4 inhibitors. Concomitant use of this medication with nitrate-containing drugs like Nitrodur is strictly and unconditionally prohibited. Consult a doctor if you use any prescription (RX) medication.

Other Interactions

It is generally considered safe to combine drugs for the treatment of erectile dysfunction with various nutritional supplements such as vitamins, minerals, chlorophyll and others. But in any case, if you are taking any kind of dietary supplement and are planning to start Levitra therapy, tell your doctor about the products you are currently taking. Some of them can still interact with Levitra, especially with regard to St. John’s wort based products.

Tell your healthcare provider if you are a smoker. The harmful effects of tobacco also spread to the reproductive system and can be both the cause of erectile dysfunction and its aggravation. Therefore, tobacco can weaken the effectiveness of your medication. In conclusion, we would like to focus on the importance of a healthy lifestyle, since this is the essential for successful treatment and even complete elimination of erectile dysfunction (in the absence of inevitable changes). Go in for sports, keep to a balanced diet and be healthy!

Is Cialis for Daily Use the Same as Regular Cialis?

February 26, 2020/in Canada Drugs /by Md. Philip Schein

According to a study by specialists at Johns Hopkins Bloomberg School of Public Health (Baltimore), the overall prevalence of erectile dysfunction in American men aged >/= 20 years reaches 20%, increasing the risk with age. This is a nontrivial situation that needs to be fought. There are countless pills on the market that can help fight erectile dysfunction, but only a part of them are actually efficient and safe.

A Few Words About Cialis

Tadalafil, the main active agent of the medication, has a significant difference from other medicines used to treat impotence. It shows a much longer triumph of efficiency, with results lasting up to 36 hours. If excitement occurs during this time period, an erection of the male genital organ will necessarily appear.

Tadalafil is perfectly absorbed when taken orally, regardless of food intake (however, extremely fatty foods can slightly reduce absorbability) for a short period of time – 30-45 minutes after ingestion. The body usually eliminates it as metabolites through the intestines and kidneys.

Cialis is effective in 70 to 80% of cases. This data was obtained as part of a research project by C.C. Carson et al. (University of North Carolina, USA, 2004). Scientists also reported that Cialis functioned independently of the severity or cause of erectile dysfunction and in men belonging to all age groups.

How to Take Regular Cialis and Its Daily Version?

Traditional Cialis is administered on demand, that is, before a sexual act. Healthcare professionals recommend to take one tablet 30-45 minutes before sex, but given the one-and-a-half-day effect duration of Cialis, such strict timing is not necessary, unless you want to have sex in the nearest time. Theoretically, you can take any traditional dosage (2.5 mg, 5 mg, 10 mg, or 20 mg), but ten and twenty milligrams appeared to be the most efficient.

As for the daily version, the maximum recommended 24-hour dose is 5 milligrams (1 tablet), and the convenient frequency of use is once a day, at about the same time, so success is eternal, until the therapy is canceled. 2.5 mg may also be effective; this dosage is indicated for some patients who take medications with potential tadalafil-related interactions or suffer from some health conditions.

Cialis daily was developed by a pharmaceutical company in order to make the patient’s sex life as spontaneous as possible, providing a great level of romanticity in relationships. With daily use, a man never suffers from erectile dysfunction symptoms, and at any time can perform in bed satisfactorily. So when it comes to question – is Cialis daily the same as regular version – the answer has a dual nature. On the one hand, these drugs have the same active ingredient and effects, but on the other hand, the order of use is different.

Cialis Effectiveness: How To Get Maximal Effect?

Additional Effects of Cialis Daily

Tadalafil is the only drug known to us and approved by pharmaceutical regulators that simultaneously treats erectile dysfunction and urinary tract problems. So, daily use of the drug also helps in eliminating the unpleasant symptoms of benign prostatic hyperplasia (BPH). The tablet treats frequent urination, nocturia and other unpleasant symptoms occurring in the urinary system. With this drug, you can kill two birds with one stone (we mean BPH & ED). Save money on the purchase of an additional medication to treat prostate enlargement, which will be simply not needed with Cialis.

In addition, tadalafil is an effective treatment for pulmonary arterial hypertension. In such cases, it is used on a daily basis to provide a permanent effect. However, there is a special version of tadalafil designed for these purposes (more precisely, to treat PAH classified as WHO functional class II and III). This medicine is called Adcirca.

Side Effects

The most common side effects are headache, nasal congestion, indigestion, and back pain, however user experience and research data show that the onset or sequential duration of these effects are rare. It’s worth noting that with constant use, tadalafil does not leave the body, this must be borne in mind if you are going to take drugs that can interact with this medication thereby increasing the risk of unwanted reactions occurring in various organs and systems.

Cialis Effectiveness: How to Get Maximum Effect and How Long Can You Take It?

February 4, 2020/in Canada Drugs /by Md. Philip Schein

Cialis (tadalafil) is the second most popular medication for erectile dysfunction (ED) treatment after Viagra. Millions of people use it, but not always they get the desired effect on the first try. Cialis is highly effective, but there are some little-known tips which may contribute to its productivity.

How to Take Cialis Properly?

There are two options for treating sexual problems with Cialis. The first one is on ‘demand’, it’s when a male takes one pill some time before sexual intercourse, and he does it not on ongoing basis, rather occasionally, when he wants to have sex. There are two classic dosages which are used for this purpose: 10 mg and 20 mg. Elevated dose (40 mg) is also available.

The second option is taking tadalafil on a daily basis. 2.5 mg pills are intended for ED treatment in some patients, e.g. in persons who take preparations which may elevate the amount of Cialis’ active agent in the blood. 5 mg tablets can be administered for erectile dysfunction and / or benign prostate hyperplasia (BPH).

How to Get Maximum Effect from Cialis?

It is not strictly prohibited to mix Cialis with alcoholic drinks, however, it is better to avoid alcohol or minimize its consumption to generate maximum response from the light-yellow pill.

Another tip is avoiding heavy meals when taking Cialis. Naturally, overloaded stomach and intestine have less strength and recourses to deal with the medication.

If you use Viagra, you can read our article which describes tips which may be helpful for enhancing its action: When Is The Best Time To Take Viagra?

It’s also recommended to wait about two hours after intake to get the maximum effect of the medication (if you take it on demand). This is linked to plasma content of tadalafil (see the subsection below).

How Long Does It Take for Cialis to Peak?

The medicine reaches peak plasma concentration within a half of an hour to six hours after ingestion. 2 hours is average time, here’s why it may be advised to wait about 60-120 min after intake to get the best result from Cialis administration.

This question is actually not relevant for people taking the medication on an everyday basis, because they have more or less stable concentration of tadalafil in the blood.

What Can I Take to Enhance Cialis?

There are no specific products which can improve Cialis effect. Some medications, especially potent inhibitors of CYP3A4 (ketoconazole, ritonavir, verapamil, etc.), may elevate its concentration in the blood due to blocking an intestine enzyme which is responsible for eliminating foreign substances from the body. But that’s not what you need.

How Many Years Can You Take Cialis?

Cialis doesn’t lose effectiveness when using for years (for instance, for 5, 10 years, etc.). It has no influence on central nervous system and cannot cause addiction. It cannot affect bodily tolerance to PDE5 inhibitors, so long-term treatment is completely appropriate and safe. So you can take it perpetually.

To know more, please read our article: Does Cialis Lose Effectiveness Over Time?

Using Cialis for Fun

Using the medication for fun is not recommended, because patients who actually have no ED are more prone to risky behavior, for instance, they can use potency pills in large quantities when clubbing/chilling at parties. Combined with party drugs, Cialis would enhance intensity of feelings, but this practice involves risks related to unpredicted fluctuations of blood pressure. In addition, users may experience slight acceleration of breathing and too fast heartbeat.

There are no loud reports concerning overuse of Cialis with dangerous consequences. However, it’s definitely known that this may be too harmful, even fatal. Some people who took dozens of Viagra pills lost the penis or even died. There is nothing strange in it, you can overdose even on water or salt, but it is worth to remember Viagra and Cialis are pharmaceuticals, i.e. foreign agents in the body, so it’s very important to follow established guidelines when treating with them.

Avanafil (Stendra) – What Is It And How Is It Different From Viagra?

February 4, 2020/in Canada Drugs /by Md. Philip Schein

Modern medicine does not stand still, so scientists are developing new treatments for erectile dysfunction. This is a well-established niche with powerful leaders like Viagra and Cialis, despite this, new findings will always be relevant, because current remedies are now without shortcomings. Avanafil is one of the most recent medications for ED. Is it a worthy alternative to famous ‘blue diamond’ and ‘yellow almond’?

What Is Avanafil (Stendra)?

Avanafil is an erectile dysfunction medication that is sold under the trademarks Stendra and Spedra. This medication was developed by VIVUS Inc, the final formula of Avanafil was released in 2009. The American FDA approved it in 2012, and in 2013 began the active promotion of this medicine in most European countries, as well as in New Zealand and Australia.

The active component of the drug is characterized by a quick effect; it begins to act 15 minutes after administration and works up to 5-6 hours.

Avanafil is dosed as 50, 100, or 200 mg pills. Patients with erectile dysfunction need to swallow one tablet 20 minutes before the intended sexual intercourse at a dose of 100 mg, which is most suitable for most men.

In individual cases, you can try to take half a tablet (50 mg) or two tablets (200 mg) in the absence of the desired effect. The maximum daily dose is two hundred milligrams. Do not use the medicine more than once a day. Avanafil can be taken regardless of food intake, but grapefruit (whole fruits and juice) should be avoided during the day of Stendra intake, as well as moderate the amount of alcohol.

Want to know more about ED pills and grapefruit interactions? Read our article:

Viagra, Cialis, Levitra and Grapefruit Non-Compatibility: Mystery Revealed

Like other similar medicines, avanafil does not affect the level of hormones and does not increase libido. In order to get the desired effect, one needs to be sexually aroused. Accordingly, Avanafil does not cause an involuntary erection (except in some cases when the patient has a predisposition to priapism).

Are There Generics of Stendra?

There are some generics of Stendra, in particular, Avana, but the assortment is not so big at the moment. However, right now customers can save their money by choosing high-quality generics from reliable drugmakers.

Stendra vs Viagra: Common Features and Differences

Both Stendra and Viagra belong to the group of phosphodiesterase type 5 inhibitors, but avanafil is a second-generation inhibitor. Due to their belonging to the same class, they act in approximately the same way.

The main differences between these medicines:

different manufacturers
various dosages (Stendra contains a larger quantity of active ingredient)
common side effects of avanafil include headache and flushing, while Viagra feature higher frequency of other adverse events, such as visual disturbances and dyspepsia.

According to a study by Italian scientists P. A. Della Camera, R. Tellini (Urologia, 2019), avanafil showed a greater tolerance profile than sildenafil (Viagra) with a lower rate of adverse events and discontinuation of therapy due to such adverse events.

Despite better performance of avanafil according to scientific studies, users’ opinion may vary. For instance, according to drugs.com Viagra achieved 8.6 points (out of 10, 205 reviews in total), while Stendra was ranked as low as 5.8 (51 reviews in total). Perhaps more time is needed to even out the situation, after all, Avanafil is a relatively new medication.

Avanafil is different from Cialis by a bigger amount of criteria, in particular, Cialis can be used for BPH (unlike Avana) and works up to 38 hrs.

Conclusion

It seems impossible to issue an unconditional verdict regarding superiority of Stendra or, vice versa, Viagra. One or another medication can work better depending on a particular patient. You may try Viagra and then switch to Stendra (if needed), or use the opposite scenario.

Disclaimer

The information on our site is provided strictly for informational purposes and should not be regarded as medical advice. Self-medication is also not recommended, especially when it comes to prescription drugs. If you have initial symptoms of some illness, it is advisable to contact your doctor (before starting the treatment) and / or visit a clinic for qualified help. If you’ve already taken avanafil with no side effects, it would be a good solution for you.

Kamagra Oral Jelly – Frequently Asked Questions

January 30, 2020/in Canada Drugs /by Md. Philip Schein

Since Viagra’s triumphant entering the world market, the pharmaceutical industry has been offering more and more solutions for the treatment of erectile dysfunction, some of which have quickly established themselves as standards. In particular, Kamagra Oral Jelly medication is extremely popular. In this article, we will provide answers to frequently asked users’ questions about Kamagra.

Why is a Jelly Form Better than Regular Tablets?

Although most other Viagra generics are available in a tablet form, this option is commercially available in the form of gel with several flavors of fruits, herbs, and aromas.

Due to its various aromas and pleasant taste, the use of Kamagra Jelly is unlike swallowing a medicine. In addition, there is no need to look for water to take this substance. You just have to tear a sachet and use the gel. Flavors such as banana, strawberry, mint, blackcurrant, vanilla, chocolate, rose, mango, lemon, caramel and berry are available.

An important feature of Oral Jelly is its faster absorption rate, due to which the beneficial effect can be observed as early as fifteen minutes after ingestion. It is because of the speed of action and ease of use that many men choose Kamagra in the form of gel. As a result, this product has become popular in many countries.

How Does Kamagra Oral Jelly Work?

Being one of the generics of the world famous blue pill, Kamagra is developed on the basis of sildenafil citrate. Of course, these medicines are similar in effectiveness. The drug inhibits the enzyme PDE5 (phosphodiesterase type 5), which leads to relaxation of the smooth muscle tissue of blood vessels and better blood flow. As a result, a man receives an erection necessary for fulfilling normal sexual intercourse.

What to Expect from Taking Kamagra Oral Jelly?

Generic Kamagra is allowed to be taken by men who have reached the age of 18. The drug is harmless to health (but can cause side effects), and does not cause systemic addiction to the body in case of prolonged use.

The frequency of gel administration depends on the sexual activity of each individual. The medication should be consumed 15-30 minutes before sexual intercourse.

Good to know: Preventing ED Wisely: 6 Useful Recommendations

Are There any Contraindications and Side Effects?

Yes. The medication should not be taken by patients with an gastric ulcer in the acute stage, serious diseases of the liver, kidneys, intestinal tract, malignant tumors, severe heart disease, individual intolerance to the active substance, as well as when taking organic nitrates.

You must read the leaflet to be fully informed about the dosage and contraindications.

Common side effects of sildenafil include headache, facial flushing, dizziness, and gastrointestinal problems. In rare cases, photosensitivity and difficulties with distinguishing between green and blue colors have been reported.

If, after taking Kamagra, you soon noticed any of the above or another sign of unhealthiness, consult a doctor.

Who is a Manufacturer of the Medicine?

Indian laboratory Ajanta Pharma Limited (an old and experienced manufacturer) produces a series of Kamagra medicines, and this drug is included in the assortment.

Wanna know more about generic drugmakers? Read our comprehensive guide to generic Viagra manufacturers.

Why is Kamagra Cheaper than Original Medicines?

Original drug manufacturers bare significantly higher R&D (research and development) costs; they spend a lot of money on licensing and marketing. Generic drugmakers avoid most of these costs, and this is a key factor in the cheapness of Kamagra.

What is the Shelf Life of the Medication?

The product has an expiration date on the packaging. The gel can be stored up to two years from the date of manufacture.

Where and How to Store the Medicine?

Keep the erectile dysfunction product in its original packaging in a dry place out of the reach of children and at a temperature below 30 degrees. Do not use it after expiration date, as this may lead to non-expectable consequences.

Sex Enhancement Drugs for Females – Latest Solutions

November 30, 2019/in Canada Drugs /by Md. Philip Schein

There are tons of medications for treating male sexual dysfunction, but what about women? Can they rely on something effective and safe? Fortunately, several years ago pharmaceutical regulators started to approve remedies intended for treatment of female sexual disorders. Scientific involvement in studying this issue continues to grow.

What’s Causing the Condition?

Healthy women usually have healthy sex drive. But when emotional problems and physical disorders appear, female libido may also suffer. Factors that may dim sex drive include:

psychoemotional stress, including stressful environment in relationship
depressive disorders and other psychical problems like anxiety
hormonal disorders that are caused by pathological fluctuations in levels of different hormones
going through female menopause (which cause such symptoms as nervousness, trouble sleeping, depression, etc., so naturally, sex desire diminishes)
other sexual problems like pain during sex, which hinder desire to have intercourse
intake of some medications, one of side effect of which is libido deterioration, these include antidepressants, oral contraceptives, medicines for treating high blood pressure (hypertension)

Well, let’s analyze the most known and popular meds for combating sex-related disorders in women.

Flibanserin (Addyi)

This medication is intended for the use by premenopausal women who suffer from sexual disorders, namely generalized hypoactive sexual desire disorder (HSDD) or premenopausal hypolipidemia. It influences reactions with participation of hormones and neurotransmitters, thereby providing beneficial effect. Flibanserin was approved several years ago but haven’t gained much popularity since its approval. Cases of this situation may be different, probably women don’t want to visit a doctor to get a prescription, probably they don’t wanna use it due to sometimes insufficient effectiveness and a considerable potential of side effects.

Vyleesi (Bremelanotide)

This is the newest medication for treating sexual desire disorders in women. Like Flibanserin, this drug is specifically intended for combating HSDD. It received FDA approval in June 2019. It features injectable way of administration: woman should make an injection prior to having sexual intercourse. The exact mechanism of Vyleesi’s effect on sex drive is unclear, but it works by influencing melanocortin receptors. The disadvantage of this medication is a high incidence of side effects, especially nausea. About 40 per cent of women who participated in clinical studies evaluating bremelanotide efficacy and safety had this adverse event.

Lovegra

It should be noted that doctors occasionally prescribe erectile dysfunction (ED) medications to women who has sexual difficulties. Lovegra is a medication which is based on the well-known sildenafil, the key component of men’s Viagra. This drug is produced by Indian generic drugmakers. It has been appeared that it also works sufficiently in women. Several scientific studies have been performed, so it is now known that sildenafil helps to enhance vaginal lubrication and blood flow to clitoris, labia, and vagina.

Female Pink Viagra

Female Pink Viagra is another name of Lovegra, but it is also sold as a separate brand name product. It also improves lubrication of the vagina, boosts blood circulation and indirectly increases desire to have sex (it has no direct effect on female libido).

Use guidelines are as follows: one should take 1 pill 30-60 minutes prior to sexual intercourse. The effect will last 4-6 hours, as in the case of ordinary male Viagra.

You can find Female Pink Viagra in this online pharmacy.

You might be interested in: Female Cialis: Does it Exist and Does It Work?

Herbal Supplements

Besides pharmaceutical solutions, there are herbal sex enhancement supplements for ladies on the market. However, it is hard to find a high-quality product which will meet a woman’s expectations. Unlike pharmaceuticals, plant-based products act slowly and their effectiveness rate is lower.

How Long Does Levitra Last – Vardenafil’s Effect Duration

November 30, 2019/in Canada Drugs /by Md. Philip Schein

Levitra (active agent vardenafil) is a common medicine used to stimulate erectile function in males suffering from ED. In general, the medication takes about 25-60 minutes to show noticeable effects. However, several factors might influence the onset of vardenafil’s effect and its duration in the body.

Levitra Effect – Duration and Influencing Factors

All PDE5 inhibitors (except Cialis and some newly developed medications) work similarly and provide virtually the same duration of action with some subtle differences. Levitra is similar to Viagra, which lasts up to 5 hours. If you take Levitra, you can expect 4-5-hour effect duration. Sometimes, it may last longer, it all depends on your body’s metabolism, dosage (higher dosages tend to work longer), and external factors, such as food intake.

Let’s analyze factors that might affect duration of Levitra’s effect:

Dosage. The lowest available dosage (5 mg) will not last as long as 20 mg.
Age. Metabolism slows down with age. Hence, older men may experience longer effect (usually this is noticeable in gentlemen after 65).
Diet. Having a heavy meal may delay the start of Levitra’s work, however, this may make it last longer, because metabolizing rate slows down. Alcohol may decrease inflow of the blood to the penile organ and thereby reduce effect of Levitra.
Drugs. There are several drugs that may interact with Levitra’s key substance in one way or another. For example, antibiotics clarithromycin and erythromycin may affect Levitra’s working period. Carefully check the leaflet and consult your health care provider to know more about interactions (this is mandatory if you are taking some potent medications and/or suffer from serious diseases, and anyway even healthy person should consult a doctor).
Psychological condition. Feeling depressed or anxious may affect your body reaction to sexual stimulation (and you might thing that there is something wrong with Levitra).
Overall health. Some diseases may decrease effectiveness and durability of the remedy. This concerns multiple sclerosis and atherosclerosis. Others, vice versa, may boost its effect, for instance, several kidney diseases might make vardenafil las longer, because they affect metabolizing processes.

In rare cases, extended effect duration is possible, this was reported by scientists in European Urology article (2006) which described duration of vardenafil efficacy of when taken 8 hours before sex.

According to some studies, it’s half-life is 4.7 hours in average, however, according to a Iñigo Sáenz de Tejada, reported data provide information on the efficiency of Levitra up to 10 hours after intake. This may be explained by the fact that vardenafil is ‘sequestered’ in target cells, as a result, tests might show low plasma levels (while medicine continues to work).

How to Speed Up the Onset of Effect?

There are some useful tips that help you if you need to get the effect as fast as possible:

Take Levitra on an empty stomach. This will accelerate absorption of vardenafil.
If you cannot take the medication on an empty stomach, then at least don’t eat food with rich fat content. Prefer light meals.
Avoid alcoholic drinks, marijuana, and illicit drugs (narcotics).

It is important: don’t take another tablet if the first one doesn’t work. This will only increase the risk of side effects.

You may be also interested in: How to Make Viagra Work Faster? Five Tips to Know

Viagra and Cialis for Patients with Special Health Care Needs: Safety Precautions

November 5, 2019/in Canada Drugs /by Md. Philip Schein

The most popular ED medications worldwide, Cialis and Viagra, pose high safety profile, however, their use in some categories of patients (who have special healthcare needs which include any impairment or limiting condition) may require great caution and may even be prohibited.

A Few Words About Viagra and Cialis

The physiological mechanism of erection is associated with releasing nitric oxide (NO formula) in the cavernous body during sexual stimulation caused by any stimuli (visual, physical, etc.). This, in turn, leads to an elevation in the rate of cGMP (cyclic guanosine monophosphate), the subsequent relaxation of the smooth muscle tissue of the penile cavernous bodies and an increase in blood flow to this organ.

The active components of Viagra and Cialis (sildenafil and tadalafil, respectively) do not have a direct relaxing effect on the isolated cavernous body, but they enhance the effect of NO, which is a fully natural erection booster, by inhibiting the enzyme PDE5 (type 5 phosphodiesterase), which leads to the breakdown of cGMP. These medications are not addictive and do not affect the quality of sperm. They act locally and specifically, however, the active components of these drugs enter the bloodstream and, accordingly, the whole body, so minor systemic effects are possible. So, in case of some diseases, these effects may be undesirable and even non-safe.

Cardiovascular Diseases and ED Medicines: When Is Their Use Potentially Hazardous?

Cialis or Viagra should desirably be avoided by patients who suffer from:

active coronary ischemia
congestive heart failure
decreased arterial pressure
complicated hypertension which is treated with multidrug therapy regimens

These medications may also be contraindicated if a patient:

has or has had other heart problems
has had surgical operation on the heart within the last 6-month period
has had a stroke, especially within a half of a year

In addition, steer clear of ED medications if you are concurrently taking organic nitrates. This group of medicines includes glyceryl trinitrate (GTN), isosorbide dinitrate and isosorbide mononitrate. GTN, also called nitroglycerin, is the most popular one. This is a widely-used medication whose purpose is to treat heart failure, hypertension, and anal fissures. It is marked under a bunch of brands, in particular, in the US, nitroglycerin is sold as Gonitro (by Pohl Boskamp), Minitran (Medicis), and Nitrolingual (Pohl Boskamp).

Renal Failure

More than 30% of patients with erectile dysfunction associated or coexisted with renal failure are at a sexually active age. As many clinicians point out, this circumstance makes this problem particularly relevant and noteworthy.

With mild to moderate degree of renal failure, the pharmacokinetic properties of sildenafil after a single oral dose of 50 mg do not change. In severe renal failure, clearance (an indicator of the rate of cleansing of biological fluids and body tissues from the active substance) of sildenafil or tadalafil decreases, which leads to an approximately twofold increase in the maximum content of the active substance in blood plasma compared with normal kidney function in gentlemen of the same age group. Therefore, with severe renal dysfunction, the doctor may decide to prescribe a minimum dosage of Viagra or a very low dosage of Cialis, since this action will be doubled due to a deterioration in the processing of active substances by the kidneys of the body.

Cirrhosis and Other Hepatic Diseases

Since the excretion of the active components of remedies for handling erectile disorders is impaired in patients with liver damage (in particular, cirrhosis, which is an irreversible substitution of healthy functioning liver tissue for non-functioning connective tissue), the dose of Viagra should be reduced to a minimum (25 mg), as in the case of renal failure. This is due to the fact that with liver diseases, the clearance of any drugs decreases, and their half-life increases significantly due to a decrease in their extraction with hepatocytes.

Use of Cialis and Viagra in Geriatry

Appropriate clinical studies have shown no limitations regarding effectiveness and usefulness of these two pharmaceuticals in patients of old age. Nevertheless, the elderly are at extended risk of many diseases, including cardiovascular, kidney, and liver ones. Such diseases may lead to the surge in action of sildenafil / tadalafil in the body, hence dosage adjustments might be required. Given these considerations, adults over 65 years old should always start ED therapy with minimal dosages, say 25mg of Viagra.

Intimacy may be contraindicated for some male patients. In particular, coronary artery disease (CAD in short) may be an insurmountable barrier for taking Viagra and Cialis. To determine the possibility of taking an anti-ED pharmaceutical by a male patient, doctors may assign him a near-maximal exercise treadmill test. As stated by Melvin D. Cheitlin, Adolph M. Hutter Jr et al. (1999, Circulation Vol. 99, No. 1), this test can help to gauge a possible stress to heart caused by sexual intercourse. If treadmill exercising shows dangerous signs electrocardiographically, then sex is simply contraindicated for the patient, and therefore he should not take erectile dysfunction pills.

Conclusions

So, if you suffer from any diseases noted above or from any disease at all, you need to be careful when taking the ‘blue pill’ or ‘yellow pill’. The tradeoff is, the milder the dosage of your medication, the fewer the potential side effects. Many coexisting diseases require consulting a healthcare professional before initiating an anti-ED treatment. In case of older male patients, the ED pills may often be unsuitable due to possibly dangerous interactions with other medicines and concurrent diseases that may make sexual activity unsafe or interfere with normal absorption and metabolism of active agents contained in impotence remedies.

Here’s an article which may be also an object of your interest: Is Viagra a Blood Thinner? Interactions with Anticoagulant Medicines

How to Generate More Response to Cialis Pills

October 31, 2019/in Canada Drugs /by Md. Philip Schein

To date, vast clinical experience has been gained in prescribing medications for the treatment of erectile dysfunction, including Cialis, which started to be used in 2002-2003. Now it has unbelievable popularity, but sometimes males feel that the pill works insufficiently. So they come up with a question – how to generate more response to Cialis tablets? We’ve gathered several tips that might be helpful for them.

1. Avoid alcohol

There is no strict contraindication regarding the possibility of combining Cialis with alcohol, whether it be beer, wine or hard liquor. But in any case, you need to know the dose, 1-2 units of alcohol (for example 1-2 glasses of beer) are allowed.

However, if you want to get the most out of your pill, you should avoid alcohol altogether. This might affect both the effect of the pill and your sexual performance.

2. Avoid Heavy Food When Taking Cialis

Eating a heavy meal, for example, a large hamburger, fries, pizza followed by a cake, anything that causes a desire to sit or lay down right after the meal, overloads your digestive system, which, naturally will slow down Cialis absorption. This especially concerns fat-rich food.

Once the medication enters the bloodstream (see below), you can eat fatty foods without a risk of negative influence on the medication’s action.

3. Wait About 2 Hours After Intake

Some time after ingestion, Cialis enters blood circulation and, subsequently, target areas, i.e. penile tissues. Any medication needs time for proper absorption. As reported by the drug manufacturer and clinicians, peak blood plasma concentrations of tadalafil should be reached a half an hour to six hours after administration (average time is 2 hours). So, to be sure that you will receive the maximum effect, it would be a good idea to take the pharmaceutical two hours before anticipated sexual intercourse. But often ‘peak’ action and ‘ordinary’ action are virtually undistinguishable, probably except when the effect comes to the end (the medicine works up to 36 hours, which is a flagship indicator when comparing with its competitors like Viagra and Levitra). However, as reported by J. Taylor et al. (BJU International, 2009) prolonged action of tadalafil makes patients more prone to long-lasting side effects, such as headache.

4. Avoid CYP3A4 inhibitors

This weird name covers a number of drugs used to treat various diseases, but united by one common feature – they inhibit cytochrome P450 3A4, one of the most important enzymes involved in the metabolism of xenobiotics in the body. The most used drugs that have an inhibitory effect on this enzyme include amiodarone, erythromycin, ketoconazole, HIV protease inhibitors, etc.

Cytochrome CYP3A4 inhibitors can dramatically increase the bioavailability of the drug. However, increasing the amount of active agent in the blood does not necessarily mean improving its effectiveness. Such drugs can raise the concentration of Cialis in the blood and thus enhance the effect, which can sometimes be compared with an acute overdose. In the case of Cialis, this can lead to severe headaches, dizziness, muscular pain, visual impairment and more.

If you are taking Viagra, this article may be helpful for you:How to Make Viagra Work Faster? 5 Must-Know Recommendations